Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer

Huang, Yu-Fang; Shen, Meng-Ru; Hsu, Keng-Fu; Cheng, Ya-Min; Chou, Cheng-Yang

doi:10.1038/sj.bjc.6604661

Cited by 44 publications

(46 citation statements)

References 33 publications

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“…Although researchers have reported preclinical and clinical implications of IGF-1 for early stage CC [10,11], studies have not determined a significant correlation between the incidence of CC and DM [12,13]. The impact of DM on OS and cancer-specific mortality of patients with early stage CC has never been addressed.…”

Section: Introductionmentioning

confidence: 99%

The Prognostic Impact of Type 2 Diabetes Mellitus on Early Cervical Cancer in Asia

et al. 2015

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Background. Many studies have shown that type 2 diabetes mellitus (DM) increases the risk for several types of cancer but not cervical cancer (CC). Although DM and insulin‐like growth factor 1 have preclinical and clinical implications for CC, less is known about the prognostic impact of DM on patients with early stage CC. Patients and Methods. We used the nationwide Taiwan Cancer Registry database to collect the characteristics of stage I–IIA cervical cancer patients diagnosed between 2004 and 2008. DM and other comorbidities were retrieved from the National Health Insurance database. Cervical cancer‐specific survival (CSS) and overall survival (OS) times of patients according to DM status were estimated using the Kaplan‐Meier method. We used a Cox proportional hazards model to calculate adjusted hazard ratios (HRs) for the effects of DM and other risk factors on mortality. Results. A total of 2,946 patients had primary stage I–IIA CC and received curative treatments, and 284 (9.6%) had DM. The 5‐year CSS and OS rates for patients with DM were significantly lower than those without DM (CSS: 85.4% vs. 91.5%; OS: 73.9% vs. 87.9%). After adjusting for clinicopathologic variables and comorbidities, DM remained an independent unfavorable prognostic factor for CSS (adjusted HR: 1.46) and OS (adjusted HR: 1.55). Conclusion. In Asian patients with early cervical cancer, DM is an independent unfavorable prognostic factor influencing both OS and CSS, even after curative treatments. Implications for Practice: Type 2 diabetes mellitus (DM) increases the incidence of several types of cancer but not cervical cancer (CC); however, less is known about the impact of DM on patients who already have CC. This study suggests that DM may increase the risk of cancer recurrence and death for early stage CC patients, even after curative treatments. Incorporating DM control should be considered part of the continuum of care for early stage CC patients, and close surveillance during routine follow‐up in this population is recommended.

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Section: Introductionmentioning

confidence: 99%

The Prognostic Impact of Type 2 Diabetes Mellitus on Early Cervical Cancer in Asia

et al. 2015

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“…In early-stage cervical cancer patients, lower IGF-I levels seemed to be associated with worse overall survival rate, but was not of an independent value, and there was no relationship between IGFBP-3 levels and survival (Huang et al, 2008).…”

Section: Serum Levels Of Igfs As Cervical Cancer Biomarkersmentioning

confidence: 94%

“…Authors found that high-grade expression of IGF-IR, is an independent predictor of cervical cancer death and recurrence, and when combined with elevated squamous cervical cancer antigen (SCC Ag) serum level, could further help identify the subgroup of patients at higher death risk. Colocalisation of IGF-I and IGF-IR in the cancerous tissues, and the lack of correlation between circulating IGF-I or IGFBP-3, and IGF-IR overexpression in cervical cancer tissue, give support to a paracrine or autocrine function of the IGF system in early-stage cervical cancer, with the corresponding adverse IGF-I stimulation of IGF-IR signaling (Huang et al, 2008).…”

Section: Tissue Expression Of Igfs As Risk or Prognosis Biomarkers Inmentioning

confidence: 99%

“…Despite intensive investigation, the tumor biology of this disease is still largely unknown. Although prognostic factors such as pelvic lymph node metastasis affects the outcome of cervical cancer, the variability in progression-free and overall survival (OS) among patients with similar clinical and pathological characteristics, makes it difficult to predict the outcome reliably (Huang et al, 2008). Current research strives to determine why certain HPV-positive women develop cervical cancer while others do not (Schaffer et al, 2007).…”

Section: The Igf System and Cervical Cancermentioning

confidence: 99%

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New Biomarkers for Cervical Cancer – Perspectives from the IGF System

Serrano¹,

Umaña‐Pérez²,

Garay‐Baquero³

et al. 2012

Topics on Cervical Cancer With an Advocacy for Prevention

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“…Ohlsson et al 17 suggested a revision in the classical somatomedin hypothesis and proposed the "dual somatomedin hypothesis" in which autocrine/ paracrine igf-1 is the main determinant of postnatal body growth, and liver-derived endocrine-acting igf-1 supplies negative feedback to gh secretion and possibly exerts other effects on carbohydrate and lipid metabolism. Paracrine/autocrine igf-1 promotes the growth of many cancers, such as acute myeloid leukemia 18 , chronic myelogenous leukemia 19 , neuroendocrine tumour 20 , breast cancer 21 , and cervical cancer 22 . Pulmonary neuroendocrine tumours such as carcinoids can produce ectopic gh in sufficient quantities to manifest as acromegaly, potentially contributing to local and distant igf activation loops 23 .…”

Section: Discussionmentioning

confidence: 99%

Expression and Clinical Significance of Insulin-Like Growth Factor 1 in Lung Cancer Tissues and Perioperative Circulation from Patients with Non-Small-Cell Lung Cancer

Tang

Liao

et al. 2016

Current Oncology

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Objective We explored the role of insulin-like growth factor 1 (igf-1) in the development of lung cancer. MethodsWe used immunohistochemistry to measure the expression of igf-1 and igf-1 receptor (igf-1r) in specimens of tissue and perioperative circulation from 80 patients with primary non-small-cell lung cancer (nsclc) and from 45 patients with benign pulmonary lesions (bpls). Correlations of those measurements with clinicopathologic characteristics and clinical follow-up were analyzed. Circulating igf-1 was measured before and after surgery in all patients. ResultsCompared with bpl specimens, nsclc specimens showed overexpression of igf-1and igf-1r (p < 0.001).The expression levels of igf-1 and igf-1r were significantly associated with advanced-stage disease (p = 0.034 and 0.029 respectively) and lymph node metastasis (p = 0.012 and 0.017 respectively), and expression of igf-1 correlated with tumour differentiation and tumour diameter (p = 0.011 and 0.021 respectively). Specimens positive for igf-1 or igf-1r were significantly correlated with shorter patient survival (p = 0.0012 and 0.0016 respectively). After surgery, circulating igf-1 was significantly elevated in patients with bpl (p = 0.0346) and significantly lower in patients with nsclc (p = 0.0030), especially in those with advanced-stage disease, a larger tumour size, regional lymphoid node metastasis, or lesser differentiation (p = 0.0092, 0.0051, 0.0131, and p < 0.001 respectively). ConclusionsIn nsclc, igf-1 and igf-1r are upregulated, and expression of those factors is correlated with tumour progression and prognosis in nsclc patients. Radical resection of nsclc can directly influence the serum concentration of igf-1. Autocrine/paracrine igf-1 might be playing an important role in the development of lung cancer.

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Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer

Cited by 44 publications

References 33 publications

The Prognostic Impact of Type 2 Diabetes Mellitus on Early Cervical Cancer in Asia

The Prognostic Impact of Type 2 Diabetes Mellitus on Early Cervical Cancer in Asia

New Biomarkers for Cervical Cancer – Perspectives from the IGF System

Expression and Clinical Significance of Insulin-Like Growth Factor 1 in Lung Cancer Tissues and Perioperative Circulation from Patients with Non-Small-Cell Lung Cancer

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