Clinical implications of in vitro drug-induced interferon gamma release from peripheral blood lymphocytes in cutaneous adverse drug reactions

Halevy, Sima; Cohen, Arnon D.; Grossman, Nili

doi:10.1016/j.jaad.2004.05.006

Cited by 41 publications

(36 citation statements)

References 43 publications

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“…A diagnostic role was implied for the in-vitro druginduced release of the Th1-type cytokine IFNg in AGEP [17,67]. A diagnostic role was also reported for the in-vitro release of the lymphokine macrophage migration inhibition factor and for the mast cell degranulation test in a series of patients with pustular drug eruptions consistent with AGEP [16].…”

Section: In-vitro Testsmentioning

confidence: 75%

Acute generalized exanthematous pustulosis

Halevy¹

2009

Current Opinion in Allergy &Amp; Clinical Immunology

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Section: In-vitro Testsmentioning

confidence: 75%

Acute generalized exanthematous pustulosis

Halevy¹

2009

Current Opinion in Allergy &Amp; Clinical Immunology

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“…A number of studies have clearly suggested that ADRs are 50-75 % more likely to occur in women than in men [9,15]. In contrast, a study in Taiwan has suggested that males seemed to be at higher risk of drug reaction [5].…”

Section: Discussionmentioning

confidence: 99%

Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study

et al. 2015

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Cutaneous adverse drug reactions (ADRs) are common. However, no prospective study assessing cutaneous ADRs is available for Chinese populations. This study aimed to assess the incidence, manifestations, causative drugs, and other factors related to cutaneous ADRs. A total of 22,866 inpatients were surveyed prospectively from January to April 2012 at the Peking Union Medical College Hospital. Only cutaneous ADRs induced by systemic drugs were considered. Fifty cases were confirmed as cutaneous ADRs, for an estimated incidence of 2.2 per 1000 during this period (95 % confidence interval 1.6-2.8). Cases of cutaneous ADRs comprised 69 % females, while 63 % of all inpatients were female (χ (2) = 0.641, P = 0.427). The department of infectious diseases was the most frequently involved department. Morbilliform exanthema (40 %) was the most frequent cutaneous ADR, followed by urticaria (23.1 %). Anti-infection drugs (36.9 %) caused most cases of cutaneous ADRs, followed by iodinated contrast media (ICM, 18.5 %) and non-steroidal anti-inflammatory drugs (NSAIDs, 18.5 %). The most frequently associated disorders were cancer (24 %), infection (22 %), cardiovascular and cerebrovascular diseases (20 %), and autoimmune diseases (18 %). In this first prospective study assessing the incidence of cutaneous ADRs in China, anti-infection drugs were the most commonly involved drugs, followed by ICM and NSAIDs. No evidence of increased cutaneous ADR incidence in AIDS or SLE patients was observed. Our findings indicate that cancer and its treatments were often related to cutaneous ADRs in China.

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“…The in vitro interferon-gamma release test from lymphocytes may also be a helpful clue for the diagnosis of ACDR [ 127 ].…”

Section: Lymphocyte Transformation Test/lymphocyte Activation Test/otmentioning

confidence: 99%

General Aspects of Adverse Cutaneous Drug Reactions

Özkaya

Yazganoğlu

2014

Adverse Cutaneous Drug Reactions to Cardiovascular Drugs

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Clinical implications of in vitro drug-induced interferon gamma release from peripheral blood lymphocytes in cutaneous adverse drug reactions

Cited by 41 publications

References 43 publications

Acute generalized exanthematous pustulosis

Acute generalized exanthematous pustulosis

Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study

General Aspects of Adverse Cutaneous Drug Reactions

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