2001
DOI: 10.1023/a:1011167924230
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Clinical impact of histologic subtypes in localized non-anaplastic nephroblastoma treated according to the trial and study SIOP-9/GPOH

Abstract: Subtyping according modified Beckwith & Palmer can be used in WT after preoperative therapy to stratify postoperative therapy in future. A milder therapy could be tested in differentiated WT at low stages and an intensified in the others with viable tumor left and poor response, i.e., mainly blastemal WT.

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Cited by 141 publications
(143 citation statements)
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“…Randomly assigned patients received postoperative chemotherapy for 27 weeks. The treatment including doxorubicin consisted of vincristine 1·5 mg/m² (maximum dose 2 mg) intravenous bolus each week for weeks 1-8, then at weeks 11,12,14,15,17,18,20,21,23,24,26, and 27, combined with actinomycin D 45 μg/kg (maximum dose 2 mg) intravenous bolus every 3 weeks from week 2, and fi ve doses of doxorubicin 50 mg/m² in 4-6 h infusions (total dose 250 mg/m²) given once every 6 weeks from week 2. The treatment excluding doxorubicin omitted doxorubicin entirely and consisted of the identical backbone of vincristine and actinomycin D only (with the same doses and timing).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Randomly assigned patients received postoperative chemotherapy for 27 weeks. The treatment including doxorubicin consisted of vincristine 1·5 mg/m² (maximum dose 2 mg) intravenous bolus each week for weeks 1-8, then at weeks 11,12,14,15,17,18,20,21,23,24,26, and 27, combined with actinomycin D 45 μg/kg (maximum dose 2 mg) intravenous bolus every 3 weeks from week 2, and fi ve doses of doxorubicin 50 mg/m² in 4-6 h infusions (total dose 250 mg/m²) given once every 6 weeks from week 2. The treatment excluding doxorubicin omitted doxorubicin entirely and consisted of the identical backbone of vincristine and actinomycin D only (with the same doses and timing).…”
Section: Methodsmentioning
confidence: 99%
“…Tumours are subtyped according to the proportion of necrosis and the cellular composition of the residual viable tumour. 13 Results from a retrospective analysis of the SIOP 9 and 93-01 trials 14,15 showed that patients with blastemal-type Wilms' tumour-of which a high proportion of any surviving viable tumour after preoperative chemotherapy consists of undiff erentiated tumour cells-have a signifi cantly worse chance of event-free survival compared with patients with other subtypes of histologically determined intermediate-risk, non-anaplastic Wilms' tumour. Therefore, we classifi ed the blastemal subtype as high-risk histology, and we excluded patients with this subtype, and the diff use anaplastic subtype, from the randomised trial.…”
Section: Introductionmentioning
confidence: 99%
“…A second advantage of preoperative chemotherapy is that response to treatment may provide a valuable prognostic indicator [50,51]. In the absence of a clear choice between up-front nephrectomy and preoperative chemotherapy, it is reasonable to base the timing of resection on factors such as tumor size, the patient's clinical condition, and the experience of the surgeon.…”
Section: Pros and Cons Of The Nwtsg And Siop Approachesmentioning
confidence: 99%
“…In the SIOP‐9/GPOH (Gesellschaft für Pädiatrische Onkologie und Hämatologie) trial, it was noticed that stromal and epithelial Wilms tumors showed a poor response to preoperative chemotherapy as measured by tumor volume before and after chemotherapy 7. We have previously reported no volume reduction or even enlargement during preoperative chemotherapy in 24 WT1 ‐mutant Wilms tumors 3.…”
Section: Introductionmentioning
confidence: 99%