Current Therapy for Wilms’ Tumor

Metzger, Monika L.; Dome, Jeffrey S.

doi:10.1634/theoncologist.10-10-815

Cited by 179 publications

(140 citation statements)

References 111 publications

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“…2 Current treatment protocols in Europe and North America are moving away from the simple objective of maximising cure, to maintaining high cure rates, whilst reducing treatment-related toxicities. 1,3 However, 80% of children with nephroblastoma live in poor countries and present at an advanced stage of disease, with malnutrition and associated co-morbidities, and face much lower survival rates. 4 Adequate and appropriate nutrition in paediatric oncology patients is essential for maintaining growth and development.…”

Section: Introductionmentioning

confidence: 99%

Relationship between nutritional status and treatment-related neutropenia in children with nephroblastoma

Hadley

Pillay

Wiles

2017

South African Journal of Clinical Nutrition

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Background: Assessment of nutritional status of paediatric oncology patients is crucial, as it may influence treatment and clinical outcomes. Concurrent malnutrition and cancer in children may lead to reduced chemotherapy delivery due to impaired tolerance and increased toxicity. Aim: This study aimed to determine the relationship between nutritional status and the prevalence, frequency and duration of treatment-related neutropenia in a cohort of South African children with nephroblastoma. Methods: Seventy-seven children between the ages of 1 and 12 years diagnosed with nephroblastoma at Inkosi Albert Luthuli Central Hospital (IALCH), Durban, between 2004 and 2012, were studied prospectively. Nutritional status was assessed using weight, height, mid-upper arm circumference (MUAC), triceps skinfold thickness (TSFT) and serum albumin. The administration of filgastrim (Neupogen®) was used as a surrogate for neutropenia and the frequency and duration of its use was recorded. Results: There was a significant relationship between the prevalence of treatment-induced neutropenia and malnutrition defined by MUAC. The mean frequency and duration of neutropenia was significantly higher in those classified as malnourished using MUAC. There was a positive correlation between frequency and duration of neutropenia. Conclusions: Malnutrition was prevalent among children with nephroblastoma. The prevalence of treatment-induced neutropenia was higher in those with poor nutritional status, identified by MUAC. Poor nutritional status according to MUAC was also linked to an increased frequency and duration of neutropenia. It is important to include MUAC in the nutritional assessment of children with nephroblastoma.

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Section: Introductionmentioning

confidence: 99%

Relationship between nutritional status and treatment-related neutropenia in children with nephroblastoma

Hadley

Pillay

Wiles

2017

South African Journal of Clinical Nutrition

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“…Данные опухоли могут содержать не только разнообразные элементы тканей, присутст-вующих в нормальной почке, но и скелетные мышцы, хрящи, слизистый и многослойный плоский эпителий [2,11].…”

Section: обзор литературыunclassified

“…В соответствии с рекомендациями протокола SIOP (International Society of Pediatric Oncology), используемого в европей-ских странах, в течение 4 нед перед операцией прово-дится химиотерапия с целью уменьшения риска интра-операционного разрыва опухоли. В большинстве случаев биопсия перед началом специфической тера-пии не проводится, и диагноз устанавливается на ос-новании данных визуализации [11]. В рамках протоко-ла SIOP диагноз ОВ может быть установлен без биопсии новообразования при соблюдении следующих условий: 1) возраст пациента от 6 месяцев до 5 лет; 2) данные визуализации свидетельствуют о наличии опухоли, исходящей из почки; 3) концентрация кате-холаминов мочи находится в пределах нормы.…”

Section: актуальность дифференциального диагноза нейро-бластомы и опуunclassified

“…Однако даже соблюдение этих критериев не позволяет с абсо-лютной точностью исключить наличие у пациента ин-траренальной опухоли, отличной от ОВ. Согласно дан-ным исследований SIOP 93-01, примерно у 5 % пациентов, инициально получавших ПХТ по протоко-лу лечения ОВ, послеоперационное гистологическое заключение не подтверждало наличие ОВ (в 1,2 % слу-чаев обнаруживались доброкачественные образования, в 3,8 % -другие злокачественные опухоли) [5,11].…”

Section: актуальность дифференциального диагноза нейро-бластомы и опуunclassified

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The differential diagnosis of neuroblastoma and Wilms' tumor: a clinical observation and review of the literature

Федорова¹

2016

Ross. ž. det. gematol. onkol.

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“…1 Relapse is often related to a poor outcome, and for patients bearing some adverse prognostic factors (APFs), event-free survival (EFS) is less than 15%. 2,3 Some different approaches have been investigated to treat this small cohort of children, including re-treatment with the same drugs, 4 new combinations such as ifosfamide plus etoposide plus carboplatin (ICE) 5,6 and final consolidation with high-dose chemotherapy (HCT) and autologous progenitor cells rescue.…”

Section: Introductionmentioning

confidence: 99%

SCT for Wilms’ tumour

Dallorso

Dini

Faraci

et al. 2008

Bone Marrow Transplant

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Thanks to advances in treatment, approximately 85-90% of patients suffering from Wilms' tumour are now cured. However, success rate after relapse is significantly lower, ranging from 25 to 45%. Several different re-induction approaches, more or less intensive according to first-line therapy and characteristics of relapse, have been proposed. A number of adverse prognostic factors related to a bad outcome after relapse have been identified and are used as inclusion criteria for entering in a programme including high-dose chemotherapy (HCT). HCT followed by autologous haematopoietic stem cell rescue has been used in small numbers of patients worldwide and promising results have been reported. Information from the European Group for Blood and Marrow Transplantation Database regarding more than 300 transplants have been gathered. In addition, literature data on rescue therapy and HCT will be discussed, such as recent treatment proposals currently under discussion within European and US cooperative groups.

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Current Therapy for Wilms’ Tumor

Cited by 179 publications

References 111 publications

Relationship between nutritional status and treatment-related neutropenia in children with nephroblastoma

Relationship between nutritional status and treatment-related neutropenia in children with nephroblastoma

The differential diagnosis of neuroblastoma and Wilms' tumor: a clinical observation and review of the literature

SCT for Wilms’ tumour

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