Clinical Impact of BK Virus Surveillance on Outcomes in Kidney Transplant Recipients

Yoon, Se-Hee; Cho, J.-H.; Jung, Hee-Yeon; Choi, Ji Young; Park, S.-H.; Kim, Y.-L.; Kim, H.-K.; Huh, Seung; Kim, C.-D.

doi:10.1016/j.transproceed.2014.11.051

Cited by 21 publications

(15 citation statements)

References 24 publications

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“…The response to our therapeutic intervention, a viremia <10 3 copies/mL, required 126 days after teriflunomide levels of 50‐100 ng/mL were reached. A long duration of BK viremia was reported in other studies with and without LEF and could contribute to the decrease of renal function, since rapid viral reduction has been shown to be associated with a stable or improving GRF …”

Section: Discussionmentioning

confidence: 66%

Stabilization of renal function after the first year of follow‐up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus‐associated nephropathy

Simard-Meilleur

Bodson-Clermont

St-Louis

et al. 2017

Transplant Infectious Dis

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Section: Discussionmentioning

confidence: 66%

Stabilization of renal function after the first year of follow‐up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus‐associated nephropathy

Simard-Meilleur

Bodson-Clermont

St-Louis

et al. 2017

Transplant Infectious Dis

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“…If performed routinely, it will help detect BKV replication even before graft damage. If pathological changes associated with BKVN develop, the management of renal damage is more difficult 41,80 . The effect of the measures is monitored by plasma PCR-BKV until its negativity.…”

Section: Bkvn Screening and Prophylaxismentioning

confidence: 99%

BK virus-induced renal allograft nephropathy

Krejčí¹,

Tichý²,

Bednaříková³

et al. 2018

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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BK virus nephropathy (BKVN) is a serious opportunistic infection threatening renal function especially during the first year after transplantation. Its incidence is now on the rise and is closely related to the level of the recipient's immune system inhibition. This is more intensive with current trends in transplantation medicine, where more potent immunosuppressive protocols are used and more aggressive antirejection therapy is applied. In the absence of BK virus (BKV) specific therapy and limited treatment options for advanced BKVN, active screening of BKV replication and subsequent preemptive adjustment of immunosuppression are essential measures to prevent BKVN. However, it remains unclear how to modify immunosuppressive protocols as well as how to address initial stages of BKV replication. This comprehensive review summarizes the currently applied and not completely uniform procedures for the detection, prophylaxis and therapy of BKV replication and BKVN. The pitfalls brought by reduced immunosuppression, as a typical response to a significant viral replication or a developed BKVN, are also mentioned, particularly in the form of graft rejection. The paper also outlines the authors' experiences, and lists currently ongoing studies on the subject. The perspectives of new, especially immune-based, procedures in the treatment of complications associated with BKV infections are highlighted. Different views on the management of patients indicated for kidney re-transplantation whose previous graft failed because of BKVN are also discussed.

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“…The value of surveillance renal biopsies in early diagnosis of BKN has been discussed in several reports[ 22 , 310 , 313 ]. BK viruria[ 22 , 297 , 306 , 308 , 317 , 322 , 332 , 334 ] and viremia[ 22 , 289 , 308 , 309 , 317 , 322 , 323 , 332 , 335 ] provide another tool for the detection of BKN. High levels of viruria or viremia correlate reasonably with the presence of BKN.…”

Section: Part B Diagnosis Of Bkn and Pathogenesis Of Bkv Infection DImentioning

confidence: 99%

“…The induction scheme that is best for prevention of BKV infection is not known. Systematic surveillance for BK viremia and viruria[ 335 , 400 , 451 , 492 ] will assist in the early detection and could benefit the outcome of BKV infections.…”

Section: Part C Treatment Of Bkv Infection: Diseases Caused By Othermentioning

confidence: 99%

BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection

Vigil

Konstantinov

Barry

et al. 2016

WJT

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Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy (BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research.

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Clinical Impact of BK Virus Surveillance on Outcomes in Kidney Transplant Recipients

Cited by 21 publications

References 24 publications

Stabilization of renal function after the first year of follow‐up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus‐associated nephropathy

Stabilization of renal function after the first year of follow‐up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus‐associated nephropathy

BK virus-induced renal allograft nephropathy

BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection

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