Stabilization of renal function after the first year of follow‐up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus‐associated nephropathy

Abstract

We confirm the early occurrence of BKPyV replication after transplantation and the short-term decline in renal function. However, early detection of BKPyV replication, prompt diagnosis, and reduction in immunosuppression may offer long-term benefits for graft function.

Determination of viremia cut‐off for risk to develop BKPyV‐associated nephropathy among kidney transplant recipients

“…It must be emphasized that the data found in our study corroborate data from literature of the most recent studies, which found higher prevalence of viremia (between 25% and 35%) in relation to previous studies reporting viremia around 10% . These differences between the studies from the first decade of the 2000s and the most current works may be related to the implementation of surveillance protocols and the fact that the protocols are not uniform in relation to the method used as screening.…”

BK Polyomavirus‐associated nephropathy managed by screening policy in a real‐life setting

“…In the present study, 20% of the PyVAN patients experienced TCMR episodes after immunosuppression reduction and 27% of the assessed patients had de novo DSA development. Other authors found a similar proportion of acute rejection episodes, mostly TCMR . De novo DSA formation was described in 14% of another PyVAN cohort, with 50% of these patients developing ABMR .…”

“…The patients that remained with functioning grafts had sustained estimated glomerular filtration rates throughout the follow‐up. Simard‐Meilleur also found stable renal function after the first year of PyVAN …”

Vigilância da replicação do poliomavírus humano BK (BKPyV) e evolução para Nefropatia Associada ao BKPyV (NABKPyV) em pacientes submetidos a transplante renal

“…Em alguns estudos, o desenvolvimento de NABKPyV tem sido associado a fatores de risco relacionados ao paciente, tais como, idade avançada e gênero masculino 95,96 , etnia branca 96,97 , diabetes mellitus 96,97,98 , uso de stent urinário 99,100 , rejeição aguda 100 e sorologia negativa para o BKPyV em receptores pediátricos 67,98 . 107,108 .…”

“…95,96 , etnia branca 96,97 , diabetes mellitus 96,97,98 , uso de stent urinário 99,100 , rejeição aguda 100 e sorologia negativa para o BKPyV em receptores pediátricos 67,69 . Na análise univariada dos fatores de risco para …”