Clinical impact of, and prognostic stratification by, F‐18 FDG PET/CT in head and neck mucosal squamous cell carcinoma

Connell, Caroline; Corry, June; Milner, Alvin; Hogg, Annette; Hicks, Rodney J.; Rischin, Danny; Peters, Lester J.

doi:10.1002/hed.20629

Cited by 141 publications

(97 citation statements)

References 26 publications

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“…The use of computed tomography (CT) scans has been reported to be convenient and helpful in the evaluation of nodal response in terms of accuracy (negative predictive value: 88.5-94%) [8,9]. Some authors have also advocated the use of post-treatment fludeoxyglucose [F18]-positron emission tomography (PET) in determining the presence or absence of residual neck disease [5][6][7]10]. Goenka et al…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, most patients with N2 or N3 disease have generally undergone initial ND consisting of upfront ND followed by concomitant chemoradiotherapy (CRT) or radiotherapy (RT), and planned ND regardless of nodal response [3,4]. However, in recent years, some investigators have advocated observation of the neck in patients initially diagnosed with N2-N3 disease, provided a complete response (CR) of regional disease is achieved after CRT or RT [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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The role of initial neck dissection for patients with node-positive oropharyngeal squamous cell carcinomas

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The role of initial neck dissection for patients with node-positive oropharyngeal squamous cell carcinomas

et al. 2014

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“…At our institution a prevalence of second primary tumours detected with panendoscopy of 16.2% has been found, with 6.4% being synchronous and 9.8% being metachronous [6]. 18 F-Fluoro-deoxy-glucose positron emission tomography (FDG-PET/CT) is increasingly used for staging of HNSCC with a considerable impact on treatment decisions [7][8][9]. In comparison to morphological imaging methods such as CT or MRI, PET/ CT has the great advantage of assessing the primary tumour, the neck nodes and the potential distant metastases and second primaries in a single examination.…”

Section: Introductionmentioning

confidence: 99%

Head and neck squamous cell carcinoma (HNSCC) – detection of synchronous primaries with 18F-FDG-PET/CT

Strobel

Haerle

Stoeckli

et al. 2009

Eur J Nucl Med Mol Imaging

116

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Purpose The aim of the study was to evaluate 18 F-FDG-PET/CT for the detection of synchronous primaries at initial staging of patients with head and neck squamous cell carcinoma (HNSCC). Methods FDG-PET/CT images acquired between March 2001 and October 2007 in 589 consecutive patients (147 women, 442 men; mean age 61.5 years, age range 32-97 years) with proven HNSCC were reviewed for the presence of synchronous primaries. Cytology, histology and/or clinical and imaging follow-up served as reference standard.Results FDG-PET/CT showed 69 suspected synchronous primaries in 62 patients of which 56 were finally confirmed in 44 patients. Of the 56 second cancers, 46 (82%) were found in the aerodigestive tract in the following locations: lung (26, 46%), head and neck (15, 17%), oesophagus (5, 9%). Ten second cancers (18%) were located outside the aerodigestive tract (colon, five; stomach, lymphoma, breast, thymus and kidney, one each). Six patients had three synchronous primaries and three patients had four synchronous cancers. Nine synchronous cancers were not detected by PET/CT (four head and neck, two lung, two oesophageal, one gastric). False-positive PET/CT findings were mainly related to benign FDG uptake in the intestine due to benign or precancerous polyps or physiological FDG uptake in other head and neck regions. Overall the prevalence of synchronous second primaries according to the reference standard was 9.5%, of which 84% were detected with FDG-PET/CT. In 80% of the patients, therapy was changed because of the detection of a synchronous primary. Conclusion FDG-PET/CT detects a considerable number of synchronous primaries (8.0% prevalence) at initial staging of patients with HNSCC. Synchronous cancers were predominantly located in the aerodigestive tract, primarily in the lung, head and neck and oesophagus. Detection of second primaries has an important impact on therapy. PET/ CT should be performed before panendoscopy.

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“…Not surprisingly, given that it is based on metabolic activity of tissues, FDG-PET has been shown to be more accurate than conventional imaging in detecting residual cancer. Marked changes in disease status have been demonstrated in patients with suspected or proven recurrence of colon cancer (Kalff et al, 2002), head and neck cancer (Connell et al, 2007), NSCLC (Hicks et al, 2001), small-cell lung cancer (Blum et al, 2004), and ovarian carcinoma (Simcock et al, 2006). In addition, PET/CT scanners allow metabolically-guided biopsy and thus can minimize sampling errors when there is a need to confirm the presence of disease pathologically.…”

Section: Fdg-pet/ctmentioning

confidence: 99%

Molecular imaging for personalized cancer care

2012

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Molecular imaging is rapidly gaining recognition as a tool with the capacity to improve every facet of cancer care. Molecular imaging in oncology can be defined as in vivo characterization and measurement of the key biomolecules and molecularly based events that are fundamental to the malignant state. This article outlines the basic principles of molecular imaging as applied in oncology with both established and emerging techniques. It provides examples of the advantages that current molecular imaging techniques offer for improving clinical cancer care as well as drug development. It also discusses the importance of molecular imaging for the emerging field of theranostics and offers a vision of how molecular imaging may one day be integrated with other diagnostic techniques to dramatically increase the efficiency and effectiveness of cancer care.

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Clinical impact of, and prognostic stratification by, F‐18 FDG PET/CT in head and neck mucosal squamous cell carcinoma

Abstract: Our results support incorporation of PET/CT into the management paradigm of head and neck mucosal squamous cell carcinoma.

Cited by 141 publications

References 26 publications

The role of initial neck dissection for patients with node-positive oropharyngeal squamous cell carcinomas

The role of initial neck dissection for patients with node-positive oropharyngeal squamous cell carcinomas

Head and neck squamous cell carcinoma (HNSCC) – detection of synchronous primaries with 18F-FDG-PET/CT

Molecular imaging for personalized cancer care

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