The role of initial neck dissection for patients with node-positive oropharyngeal squamous cell carcinomas

Changing trends in the management of the neck in oropharyngeal squamous cell carcinoma

“…Sakashita et al compared patients with primary surgical neck treatment to those treated with definitive RT or CRT combined with salvage neck dissection when needed, which is similar to data reported here. Their results lacked a statistically significant difference between the 2 groups; the regional control rates were 84.9% and 77.6%, respectively . They found somewhat more regional recurrences than reported in many others studies, including ours.…”

Outcomes of surgically treated human papillomavirus–related oropharyngeal squamous cell carcinoma with N3 disease

“…The few studies that specifically evaluate outcomes of a primary surgical paradigm for N3 OPSCC show similarly high survival rates but are limited by sample size. Sakashita et al reported a 100% 4‐year OS for six patients, and Smyth et al found a 5‐year overall survival of 80% in 10 patients.…”

“…Ultimately, however, survival outcomes specific to HPV‐related N3 disease are unclear given the relative lack of available data. Many reports of treatment outcomes for N3 neck disease either group multiple head and neck subsites or do not include HPV status if reporting on oropharyngeal primaries . Those that include specifically HPV‐related disease often group N2 and N3 stages for analysis or have a very limited sample size of N3 patients …”

Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma

“…In this study, we analyzed whether renal function is a prognostic factor in oropharyngeal SCC using data obtained from 12 institutions across Japan …”

“…[4][5][6][7] In this study, we analyzed whether renal function is a prognostic factor in oropharyngeal SCC using data obtained from 12 institutions across Japan. [8][9][10] gathered from 12 institutions belonging to the Head and Neck Cancer Study Group in the Japan Clinical Oncology Group. Overall, 37 patients who received palliative therapy, 16 patients with non-SCC, and 10 patients for whom complete data could not be obtained were excluded from further analysis, and the data for the remaining 460 patients were analyzed retrospectively.…”