Clinical immunology Original treatment methods of frequently recurrent chronic herpetic infection caused by herpes virus type 1 and type 2

Herasun, Borys; Hrytsko, Roman

doi:10.5114/ceji.2012.32726

Cited by 5 publications

(4 citation statements)

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“…The latter enables us to suppose that the influence of intradermal autoleukocyte immunization on TNF-α synthesis may depend on the condition of immunocompetent cells and correlation of regulatory cytokines (pro-inflammatory and anti-inflammatory) in a patient's blood. The mechanism of influence of autoleukocyte immunization on autoimmune processes was described previously [ 21 , 23 , 26 ]. An important aspect is the process of Jerne network correction – idiotypic-anti-idiotypic regulation of immune response, which is confirmed by an increased amount of anti-idiotypic antibodies in a patient's blood serum after leukocyte immunization.…”

Section: Results Of Investigation and Their Discussionmentioning

confidence: 99%

“…However, even at present the obtained results confirm the expediency of this method inclusion into the complex treatment of diseases with a high activity of TNF-α. Besides, a significantly broader range of this procedure results in a reduction of precipitating cold proteins – cryoglobulins [ 20 , 24 ] and, as opposite to antibodies-inhibitors of TNF-α, may promote intensification of antiviral cell-mediated and humoral immunities [ 26 ]. And it is important for autoimmune processes, trigger factor of which can be viruses.…”

Section: Results Of Investigation and Their Discussionmentioning

confidence: 99%

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Original inhibition method of excessive synthesis of pro-inflammatory cytokine of tumour necrosis factor α

Zinchuk¹,

Holubovska²,

Шкурба³

et al. 2015

cejoi

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Influence on pro- and anti-inflammatory cytokines of an ill person is an urgent aspect of treatment of many diseases. For inhibition of synthesis of a high level of pro-inflammatory cytokines, medications which are recombinant monoclonal antibodies, especially to tumour necrosis factor α (TNF-α), are used. However, these methods of treatment require further improvement by elaborating new approaches with a wider spectrum of influence on the immune system.A completely new method of reduction in high activity of TN F-α with the method of intradermal autoleukocyte immunization is presented in the article. Investigation was performed in a group of patients with psoriasis (24) with a high level of TNF-α in the blood (over 30 pg/ml). Simultaneously such investigation was performed on patients with psoriasis (9) without TNF-α detected (0 pg/ml).As a result of immunization, a significant reduction in TNF-α occurred in all patients with its high level, in 16 (66.7%) from 24 patients – to 0-5 pg/ml. The level of reduction and duration of the achieved effect was of an individual character and requires further investigation. However, the achieved results prove the expediency of administration of this immunization method for patients requiring reduction of TNF-α synthesis.However, the content of TNF-α in blood serum could not be detected in most patients with a low level of cytokine (in 6 from 9) after immunization (as well as before immunization), but an increase in its level from 0 to 5-8 pg/ml was observed in 3 patients. On the basis of the conducted research, the authors suggest that the influence of immunization on cytokine synthesis depends on the condition of immune cells and correlation of pro- and anti-inflammatory cytokines in a patient's skin.

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Section: Results Of Investigation and Their Discussionmentioning

confidence: 99%

Section: Results Of Investigation and Their Discussionmentioning

confidence: 99%

Original inhibition method of excessive synthesis of pro-inflammatory cytokine of tumour necrosis factor α

Zinchuk¹,

Holubovska²,

Шкурба³

et al. 2015

cejoi

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“…Patients with cryoglobulins present in the blood serum received non–drug therapy of the cryoglobulinemia by means of intracutaneous immunization with autoleukocytes. [ 9 – 12 ].…”

Section: Methodsmentioning

confidence: 99%

Correction of fertility disorders in patients with cryoglobulinemia

Gerasun¹,

Kopets²,

Hrytsko³

et al. 2013

CEJU

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IntroductionCryoglobulinemia can be among the causes of sperm bad quality. But conventional examination algorithm for patients with idiopathic oligozoospermia makes no provision for cryoglobulin determination in blood serum.Materials and methodsWe examined 55 patients with idiopathic spermatogenesis disorder. Each patient had cryoglobulin determined in blood serum. For this purpose, optical density of the patient's blood serum before and after its 7–day cooling at a temperature of 4°C was compared. Type of cryoglobulins was established by the method evaluation of serum optic density in different periods of cooling incubation (before and after cooling) using the curves of temperature resistance for comparison. Patients with cryoglobulinemia underwent intracutaneous immunization with autoleukocytes separated from heparinized venous blood.ResultsCryoglobulins were revealed in 16 patients of all 55 examined (29.09%): in six patients’ cryoglobulins of second type; in nine – third type and in one patient – cryoglobulins of first type were detected. In a control group, which consisted of 50 men is blood – donors’ frequency of cryoglobulinemia was 2%.Pathogenetic connection between cryoglobulinemia and disturbances in sperm quality is also supported by the fact that after autoleukocyte immunization in patients who positively responded to cryoglobulinemia treatment (14 persons of 16 or 87.5%) spermogram was found to be improved. Thus, in 12 patient number of spermatozoa. In all patients progressive motility and precentage of normal forms increased with spermatoza concentration.ConclusionsIt is reasonable to include determination of cryoglobulins in blood serum for patients with idiopathic oligo– and zoospermia.

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“…Мета дослідження: випробування внутрішньошкірної імунізації інактивованими автолейкоцитами в декількох на прямках: 1) для лікування автоімунних процесів, зокрема при позапечінкових проявах у хворих на хронічний вірусний гепа тит С [10]; 2) для пригнічення синтезу кріоглобулінів у хворих з ідіопатичною олігозооспермією [11,12]; 3) для зниження ви сокої активності прозапальних цитокінів -TNF  [13, 14]; 4) для використання автолімфоцитів, отриманих від пацієнтів з вірусною інфекцією, як лікувальної вакцини [15,16].…”

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New method for the treatment autoimmune process

Герасун¹,

Грицко²,

Герасун³

et al. 2016

Family Medicine

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Clinical immunology Original treatment methods of frequently recurrent chronic herpetic infection caused by herpes virus type 1 and type 2

Abstract: In the article we presented the results of clinical probation of new method of treatment of repeatedly recrudescent herpes simplex virus infection cells, vaccination. (Centr Eur J Immunol 2012; 37 (4): 362-364)

Cited by 5 publications

References 1 publication

Original inhibition method of excessive synthesis of pro-inflammatory cytokine of tumour necrosis factor α

Original inhibition method of excessive synthesis of pro-inflammatory cytokine of tumour necrosis factor α

Correction of fertility disorders in patients with cryoglobulinemia

New method for the treatment autoimmune process

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