Clinical-Immunological Monitoring of Etiological Structure of Idiopathic Optic Neuritis

Поваляева, Д А; Danilova, G.P.; Emanova, L.P.

doi:10.17238/pmj1609-1175.2018.2.55-63

Cited by 2 publications

(2 citation statements)

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“…An analysis of the literature data points to the huge role of the herpesvirus family in the development of human infections common in nature [2,4,9,10,12].…”

Section: Resultsmentioning

confidence: 99%

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Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis

et al. 2023

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An increase in the incidence of optic neuritis among the working-age population, as well as an unpromising prognosis for vision due to the development of optic nerve atrophy, determines the high social significance of this problem. The aim of the work is to analyze the effect of Imunofan at the parameters of cellular immunity and clinical symptoms of the disease in the complex treatment of optic neuritis associated with herpes virus infection. The study involved 37 people (37 eyes) with acute optic neuritis associated with herpes infection. The treatment regimen included the appointment of a dexamethasone solution according to a decreasing scheme, a 1% solution of the drug Emoxipin 0.5 mL and a 12.5% solution of the drug Dicynone 0.5 mL through an irrigation system implanted in the retrobulbar space, in combination with the neuroprotection drugs (Pikamilon and Semax) for 10 days. All patients were divided into 2 groups. The main group consisted of 20 patients who received Imunofan to the treatment regimen in addition. The comparison group included 17 patients who were treated only according to the method described above. The course of treatment lasted 10 days. The analysis of the data showed a more significant positive dynamics of cellular immunity parameters in those who received immunotherapy. Our studies showed the effectiveness of this drug in the complex treatment of optic neuritis associated with herpes infection, what is confirmed by the acceleration of inflammation relief, a more significant increase in visual functions of patients treated with Imunofan, and a lower percentage of optic nerve atrophy. In this group of patients, changes in the parameters of the cellular link of immunity occurred earlier and remained stable throughout the entire period of observation. According to our data, an intergroup assessment of the immunoregulatory index showed its faster increase in patients of the comparison group who received Imunofan, and reached normal values already 6 months after treatment. The clinical effectiveness of Imunofan in the complex therapy of optic neuritis associated with herpes infection was characterized by a reduction in the period of relief of signs of inflammation in the optic nerve by 2 times or more, by an increase in the maximum corrected visual acuity by 4.5 times, and by a decrease in the incidence of recurrence of optic neuritis by 2 times over a 12 months observation period.

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“…An analysis of the literature data points to the huge role of the herpesvirus family in the development of human infections common in nature [2,4,9,10,12].…”

Section: Resultsmentioning

confidence: 99%

“…Along with CNS diseases, including autoimmune damage to the optic nerve, acute and chronic bacterial and viral infections, including herpesvirus infection (HVI) [5,6,10,11], are of great importance in the etiology of ON.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis

et al. 2023

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Diagnosis and treatment of optic neuritis as a manifestation of persistent herpesvirus infection: a clinical case

Issakhanova,

Duisenova,

Kurmasheva

et al. 2024

Rossijskij oftalʹmologičeskij žurnal

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A clinical case of bilateral descending optic neuritis in a 63-year-old patient is presented. The patient, whose age is beyond the normal limit for this pathology, was previously treated for neuritis of the right eye, which had no effect and led to a complete atrophy of the optic nerve (ON). A timely correct diagnostics of the left eye, which revealed structural disorders of the optic nerve accompanied by inflammatory viral changes of brain tissue, was a key factor in choosing an adequate treatment, which helped retain visual functions. The clinical observation illustrates the polyetiological nature of inflammation of the ON, the viral agent playing a leading role. Importantly, ophthalmic manifestations of the herpesvirus infection may remain the only sign of this pathology for a long time, so the ophthalmologist must always be on the alert regarding the viral genesis of the disease.

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Clinical-Immunological Monitoring of Etiological Structure of Idiopathic Optic Neuritis

Cited by 2 publications

References 0 publications

Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis

Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis

Diagnosis and treatment of optic neuritis as a manifestation of persistent herpesvirus infection: a clinical case

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