Clinical, imaging, and follow-up observations of patients with anti-GABA_B receptor encephalitis

Abstract

Anti-GABA receptor encephalitis is a rare, unique autoimmune disease, and is often associated with tumors. It should be considered in the differential diagnosis for middle and senior-aged patients who present with predominantly limbic encephalitis symptoms. Importantly, earlier recognition of this potentially treatable condition could improve its overall prognosis.

Clinical features and outcomes of Chinese patients with anti‑γ‑aminobutyric acid B receptor encephalitis

“…Clinical manifestations of encephalitis patients with anti-GABABR antibody. affects middle-aged and aged males who have a high risk of receptor encephalitis, usually manifesting as LE, and has symptoms including seizures, memory deficits, psychosis and altered consciousness (4)(5)(6)(7)(8)(9). Furthermore, seizures are frequently the initial and most prominent symptom, which are usually refractory to anti-epileptic drugs but exhibit a response to immunotherapy (4)(5)(6)(7)(8)(9)13).…”

“…To date, only a small number of cases of positivity for antibodies against GABAB have been reported in the Asian population (7)(8)(9). Therefore, the present study investigated the clinical manifestations, therapy and outcomes in Chinese patients with GABAB receptor antibodies.…”

“…Anti-GABAB receptor encephalitis is a relatively rare disease: Only 100 cases have been reported in the literature since 2010 (4)(5)(6)(7)(8)(9). In addition, ~1/2 of patients with antibodies against GABAB receptor encephalitis have small cell lung cancer (SCLC).…”

“…In addition, ~1/2 of patients with antibodies against GABAB receptor encephalitis have small cell lung cancer (SCLC). The majority of patients exhibit neurological improvement after immunotherapy and tumor therapy (4)(5)(6)(7)(8)(9).…”

Guilty by Association: KCTD16 and GABABR Antibodies in Paraneoplastic Limbic Encephalitis

“…The g-aminobutyric acid B receptor (GABA B R) antibody is a relatively recent addition to this expanding list. With around 150 cases reported prior to this series [2][3][4][5][6][7][8][9][10][11] (Table 2), this entity is rare-approximately 20 times less frequent than the anti-NMDAR syndrome, 2 for instance-although it is likely underdiagnosed.…”