Clinical, Hematological Changes and Therapeutic Efficacy of Buparvaquone with Oxytetracycline against the Natural Infection of Theileria Annulata in Cattle

Saravanan, M.; Ranjithkumar, M.; Prasanth, M. Babu; Yogeshpriya, N.; Jayalakshmi, K.; Kannan, K.

doi:10.5455/ijlr.20170716010544

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…One of the significant elements affecting tick density is the presence of deers [Fanelli, 2021]. Theileria, a hemoprotozoan disease that is spread by ticks causes a cascade of symptoms which include hepatic and renal dysfunction, hypoproteinemia, hypoalbuminemia, and hypophosphatemia [Kannan, 2017]. Anaplasma marginale and Anaplasma centrale of the order Rickettsiales are the main causes of anaplasmosis, which was once referred to as gall sickness [Di Domenico et al 2016;Sivajothi and Reddy, 2022].…”

Section: Introductionmentioning

confidence: 99%

Hemato-Chemical Variations- A Diagnostic Tool for Babesia, Theileria and Anaplasma Infections in Captive Hog Deer (Axis Porcinus)

Azhar,

Saleem,

Safdar

et al. 2024

Preprint

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Hog deer are an essential component of Pakistan’s biodiversity. Their conservation helps maintain integrity of local ecosystems, contributing to overall stability and balance of region’s wildlife populations. In Pakistan, they are classified as an endangered species according to IUCN. Theileria, babesia and anaplasma are among most prevalent blood parasites in ruminants which require diagnosis at early stages of the infection so that treatment protocols can be followed and more severe pathological alterations can be prevented. The changes in hemato-chemical parameters caused by Theileria, babesia and anaplasma were recorded individually and then compared with healthy group of hog deer respectively. Alterations in hemato-chemical parameters produced by these parasite-infected hog deer were assessed as potential diagnostic tools for distinguishing between individual blood parasites. Total leukocyte count, monocytes and eosinophils were observed to be higher than normal in babesia infected hog deer while level was lower than normal hog deer in anaplasma and theileria infected hog deer. The main objective of this study is to promote early diagnosis of parasitic infections in hog deer to facilitate prompt treatment, pathological prevention and allocate resources for further research on hemato-chemical parameters as diagnostic tools, enhancing understanding and management of blood parasite infections in hog deer.

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Section: Introductionmentioning

confidence: 99%

Hemato-Chemical Variations- A Diagnostic Tool for Babesia, Theileria and Anaplasma Infections in Captive Hog Deer (Axis Porcinus)

Azhar,

Saleem,

Safdar

et al. 2024

Preprint

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“…Many problems were shown due to the use of the smear methods that reflect low sensitivity for the diagnosis of carrier animals (9). For a quick and accurate diagnosis, molecular methods such as PCR techniques have been employed for the identification of Theileria spp (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Clinical and molecular identification of ruling Theileria annulata strains in cattle calves in Al-Diwaniyah province, Iraq

Alfatlawi¹,

Jasim²,

Jarad³

et al. 2021

IJVS

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This study aimed to investigate the evolutionary status of T. annulata in Al-Diwaniyah province, Iraq. In this study, the clinical examination of 50 infected animals was performed with blood sample collection (2.5ml per animal), and drug targets cytochrome b, a vital component of the electron transfer chain in the mitochondria of the protozoan, cytb gene was targeted using a polymerase chain reaction (PCR) procedure. Also, 18S rRNA gene as a molecular target for the PCR and a partial gene sequencing (PGS) were included. The PCR that involved using the 18S rRNA and cytb genes as genetic targets revealed amplification of the targeted pieces at 620bp and 1092bp, respectively, in all tested samples. The18S rRNA gene sequence of local T. annulata isolates were aligned with global reference strains for T. annulata recorded in the GenBank. The local strains were close, 100%, in their identity to isolates from Iran, Turkey, and Pakistan; however, they were 99% similar to a nucleotide sequences from India and Bangladesh. Diseased calves showed clinical signs such as high fever (40.3-41.5°C), decreased appetite or in appetence, asymmetrical enlargement of superficial lymph nodes particularly the prescapular ones, some cases with diarrhea, pale or icteric mucus membrane of eyes, bulging eyes, lacrimation, ecchymotic hemorrhages on the sclera, incoordination, nervous signs (Dullness, depression, lethargy), salivation, and bloated young calves. The data observed from the present inspecting work may reveal genetic evolution in the local strains with others recorded in the GeneBank. This means that our local strains might have close relationships with some global strains.

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Mutations in Theileria Annulata Cytochrome B Gene Associated with Buparvaquone Resistance in Cattle, Egypt

Yousef¹

2020

PVJ

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Buparvaquone is now the principle medicinal drug utilized against tropical theileriosis. The current study was conducted to determine the potential association between the resistance against buparvaquone and the occurrence of mutations in the Cytochrome b (Cyto b) gene of Theileria annulata (T. annulata) in cattle under Egyptian conditions. We sequenced the Cyto b gene of T. annulata of 6 blood samples collected from 1 responding and 5 non-responding cattle to buparvaquone treatment. The analysis revealed that two mutations occurred in codons 253 and 262 within the quinol oxidation (Qo2) drug-binding site of the five resistant isolates. Two mutations in the Qo1 site were found together in the buparvaquone sensitive isolate only. Our findings suggest that the failure of buparvaquone therapy could be attributed to the presence of single or double point mutations at the Qo2 site of T. annulata Cyto b gene.

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Clinical, Hematological Changes and Therapeutic Efficacy of Buparvaquone with Oxytetracycline against the Natural Infection of Theileria Annulata in Cattle

Abstract: Abstract

Cited by 3 publications

References 6 publications

Hemato-Chemical Variations- A Diagnostic Tool for Babesia, Theileria and Anaplasma Infections in Captive Hog Deer (Axis Porcinus)

Hemato-Chemical Variations- A Diagnostic Tool for Babesia, Theileria and Anaplasma Infections in Captive Hog Deer (Axis Porcinus)

Clinical and molecular identification of ruling Theileria annulata strains in cattle calves in Al-Diwaniyah province, Iraq

Mutations in Theileria Annulata Cytochrome B Gene Associated with Buparvaquone Resistance in Cattle, Egypt

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