Clinical grading of vernal keratoconjunctivitis

Bombardieri, Stefano; Sacchetti, Marta; Mantelli, Flavio; Lambìase, Alessandro

doi:10.1097/aci.0b013e3282efb726

Cited by 138 publications

(143 citation statements)

References 27 publications

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“…Steroids can be highly effective, but there are risks of glaucoma, superinfection with viruses and bacteria due to local immunosuppression, delayed wound healing, and cataract induction warrant cautious use of topical steroids [17][18][19][20][21][22][23][24]. Therefore, non-steroidal medications are desirable for the treatment of VKC as alternative, but new topical agents with dual antiallergic activity (mast cell stabilizers and antihistamine) may also be used for long-term treatment of allergic inflammation to alleviate signs and symptoms of the disease [21,25,26].…”

Section: Discussionmentioning

confidence: 99%

Topical Cyclosporine A 0.05% Eyedrops in the Treatment of Vernal Keratoconjunctivitis – Randomized Placebo-Controlled Trial

Keklíkçí¹,

Dursun²,

Cingü³

2014

Adv Clin Exp Med

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Background. Vernal keratoconjunctivitis (VKC) is a chronic, bilateral inflammation of the conjunctiva that mostly affects children and young adult males. Management of VKC is primarily aimed at reducing symptoms and preventing serious vision threatening sequelae. Objectives. To assess the efficacy of topical cyclosporine A (CsA) 0.05% on the signs and symtomps in the management of VKC. Material and Methods. This is a placebo-controlled, randomized prospective study. Sixty-two patients with VKC were included in this study. Patients were randomly assigned (1 : 1) to treatment with topical 0.05% CsA eyedrops or a placebo (artificial tears) for a period of 4 weeks, 4 times daily. Ocular signs and symptoms were in all patients scored at entry and at the end of 4 weeks. Results. When pre-treatment mean signs and symptoms scores were compared in both groups, there was no significant difference (p > 0.05). However, mean post-treatment scores as regards signs and symptoms were found to be lower in cyclosporine group than those in placebo group (p < 0.001). No side effects of the treatment with CsA 0.05% eyedrops were observed. Conclusions. It was found that topical CsA 0.05% eyedrops were safe and effective in the treatment of patients with VKC (Adv Clin Exp Med 2014, 23, 3, 455-461).

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Section: Discussionmentioning

confidence: 99%

Topical Cyclosporine A 0.05% Eyedrops in the Treatment of Vernal Keratoconjunctivitis – Randomized Placebo-Controlled Trial

Keklíkçí¹,

Dursun²,

Cingü³

2014

Adv Clin Exp Med

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“…A possible reason for this is the difficult of effectively evaluating the severity of different diseases together with all of their diverse clinical features. Thus, panelists are in agreement that staging of specific types of ocular allergic diseases are recommended, as those recently published based on severity of signs and symptoms of VKC (17) and AKC (18) . Advances in the understanding of ocular allergic disorders mechanisms have provided foundation for more rational guidelines of treatment of these diseases.…”

Section: Discussionmentioning

confidence: 99%

Ocular allergy latin american consensus

Santos

Alves

Freitas

et al. 2011

Arq. Bras. Oftalmol.

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Study carried out at the Primeira parte (Questionários): online. Segunda parte (Meeting): OrlandoMiami, USA. Terceira Parte (Análise Estatística): São Paulo (SP), Brazil. ABSTRACTPurpose: To establish current definition, classification and staging, and to develop diagnosis and treatment recommendations for ocular allergy, by using Delphi approach. Methods: Ten Latin American experts on ocular allergy participated in a 4-round Delphi panel approach. Four surveys were constructed and answered by panelists. A two-thirds majority was defined as consensus. Definition, classification, staging and diagnosis and treatment recommendations were the main outcomes.Results: "Ocular allergy" was proposed as the general term to describe ocular allergic diseases. Consensus regarding classification was not reached. Signs and symptoms were considered extremely important for the diagnosis. It was consensus that a staging system should be proposed based on the disease severity. Environmental control, avoidance of allergens and the use of artificial tears were recommended as first line treatment. The secondary treatment should include topical anti-histamines, mast cell stabilizers and multi actions drugs. Topical non-steroidal anti-inflammatory and vasoconstrictors were not recommended. Topical corticosteroids were recommended as third line of treatment for the most severe keratoconjunctivitis. Consensus was not reached regarding the use of systemic corticosteroids or immunosuppressant. Surgical approach and unconventional treatments were not recommended as routine. Conclusion:The task of creating guidelines for ocular allergies showed to be very complex. Many controversial topics remain unsolved. A larger consensus including experts from different groups around the world may be needed to further improve the current recommendations for several aspects of ocular allergy.

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“…bulbar hyperemia, conjunctival secretions, papillary reaction, trantas spots, corneal involvement at presentation, the severity of disease was graded as per the method described by Bonini et al 6 Grade 0,1,2 was classified as mild and Grade 3, 4, 5 as severe VKC.…”

Section: Methodsmentioning

confidence: 99%

Vernal Keratoconjunctivitis in School Children in North Bangalore: An Epidemiological and Clinical Evaluation

Ashwini¹,

Dhatri²,

Rajeev³

2015

jemds

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OBJECTIVE:To describe the demographic profile, clinical presentation and health seeking behaviour in children with vernal keratoconjunctivitis in north Bangalore. MATERIALS AND METHODS: Cross sectional survey of school children conducted between Feb 2014 to May 2014. Children were interviewed using a questionnaire on Vernal keratoconjunctivitis related symptoms. Children received a full eye examination including vision using snellen chart, slit lamp examination and fundus examination where required. RESULTS: A total of 2500 children screened, 450 children had Vernal keratoconjunctivitis related symptoms and signs. Mean age at presentation was 9.1yrs with male predominance of children. Ocular itching was the predominant symptom (88%). Majority of the patients had mixed form of Vernal keratoconjunctivitis (62%). Medical care for eye problems was sought in only 22% of the patients. Vernal keratoconjunctivitis related complications such as corneal scaring (9%), peripheral corneal neovascularization (8%) and limbal stem cell deficiency (2%) were seen. CONCLUSION: This survey of prevalence and clinical pattern of VKC shows higher prevalence rate in this area as compared to other tropical countries but the clinical pattern of VKC seen is essentially similar to that seen in other tropical countries. Long term follow up is required to ascertain the risk factors for increasing prevalence rate and the need for better primary eye care and accessibility of eye care to the population in the community.

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Clinical grading of vernal keratoconjunctivitis

Cited by 138 publications

References 27 publications

Topical Cyclosporine A 0.05% Eyedrops in the Treatment of Vernal Keratoconjunctivitis – Randomized Placebo-Controlled Trial

Topical Cyclosporine A 0.05% Eyedrops in the Treatment of Vernal Keratoconjunctivitis – Randomized Placebo-Controlled Trial

Ocular allergy latin american consensus

Vernal Keratoconjunctivitis in School Children in North Bangalore: An Epidemiological and Clinical Evaluation

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