Clinical, functional and biochemical changes during recovery from COPD exacerbations

Koutsokera, Angela; Kiropoulos, Theodoros; Nikoulis, Dimitrios J.; Daniil, Zoe; Tsolaki, Vasiliki; Tanou, Kalliopi; Papaioannou, Andriana Ι.; Germenis, Anastasios E.; Gourgoulianis, Konstantinos; Κostikas, Κonstantinos

doi:10.1016/j.rmed.2008.12.006

Cited by 70 publications

(59 citation statements)

References 31 publications

(29 reference statements)

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“…In a previous study from our group, the measurement of several serum biomarkers, including CRP, serum amyloid-A, tumour necrosis factor-a, interleukin-6 and fibrinogen, failed to identify patients with early or late recovery from hospitalisation for AECOPD [23]. In a Swiss study, STOLZ et al [24] showed that plasma pro-adrenomedullin and pro-endothelin levels were associated with the length of hospitalisation, but only pro-adrenomedullin is a predictor of long-term survival.…”

Section: Discussionmentioning

confidence: 78%

Serum uric acid as a predictor of mortality and future exacerbations of COPD

Bartziokas

Papaioannou

Loukides

et al. 2013

European Respiratory Journal

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Serum uric acid is increased in respiratory disease, especially in the presence of hypoxia and systemic inflammation. We evaluated serum uric acid as a biomarker for prediction of mortality and future acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Serum uric acid was measured in 314 eligible consecutive patients on admission for AECOPD. Patients were evaluated monthly for 1 year.Uric acid levels were higher in patients with more severe airflow limitation and in those experiencing frequent exacerbations. High uric acid levels (o6.9 mg?dL -1 ) were an independent predictor of 30-day mortality in multivariate Cox regression analysis (HR 1.317, 95% CI 1.011-1.736; p50.044), but not of 1-year mortality. Patients with high serum uric acid required more prolonged hospitalisation, and more often needed noninvasive ventilation and admission to the intensive care unit within 30 days. In addition, high uric acid levels were associated with increased risk and hospitalisation for AECOPD in 1 year in multivariate Poisson regression analysis (incidence rate ratio 1.184 (95% CI 1.125-1.246) and 1.190 (95% CI 1.105-1.282), respectively; both p,0.001).Serum uric acid is associated with increased 30-day mortality and risk for AECOPD and hospitalisations in 1-year follow-up. This low-cost biomarker may be useful in the identification of high-risk chronic obstructive pulmonary disease patients that could benefit from intensive management. @ERSpublications Serum uric acid was linked with airflow limitation in COPD and predicted mortality and future exacerbations

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Section: Discussionmentioning

confidence: 78%

Serum uric acid as a predictor of mortality and future exacerbations of COPD

Bartziokas

Papaioannou

Loukides

et al. 2013

European Respiratory Journal

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“…В проспективных исследованиях была показана тесная корреляционная связь длительности госпита лизации и сывороточного уровня копептина [11], про адреномедуллина [24], проэндотелина 1 [24], альбу мина [25], тропонина Т [26] и натрийуретического пептида [27]. В одном из исследований оценивались несколько биомаркеров (в т. ч. сывороточные марке ры окислительного стресса, СРБ, сывороточный амилоид А, TNF α, IL 6 и фибриноген) в отношении возможности выявления пациентов с меньшей про должительностью госпитализации, однако, несмотря на длительно присутствовавшие изменения в уров нях этих биомаркеров, ни один из них не явился предиктором снижения проявлений симптомов в ранние сроки [12]. При изучении выраженности симптомов обострения ХОБЛ, темпа их обратного развития и частоты рецидивов показано, что пациен ты, у которых выраженность симптомов не достигла исходного уровня к 35 му дню, наблюдалось стойкое повышение уровня СРБ в сыворотке крови [28].…”

Section: обзорыunclassified

“…Некоторые биомаркеры, такие как СРБ и про кальцитонин, которые определялись в начале госпи тализации по поводу обострения ХОБЛ, не являлись предикторами летального исхода в ближайшем пери оде [11,12], а в противоположность этому, повышен ные уровни копептина были связаны с высоким рис ком смерти во время пребывания в стационаре [11].…”

Section: обзорыunclassified

“…В большинстве исследований показано увеличение уровня воспалительных биомаркеров в начале процес са развития обострения и их снижение по мере стиха ния симптомов [11][12][13]. Уровень одного из самых изу ченных биомаркеров -С реактивного белка (СРБ), оказался выше у пациентов с обострением 1 го типа (по классификации Anthonisen) по сравнению со 2 м и 3 м типами (в среднем 35,3, 18,6 и 12,6 мг / л соот ветственно; р = 0,003), что в определенной степени может служить доказательством преимущественно инфекционной этиологии обострений [11].…”

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Diagnostic values of biomarkers in acute exacerbation of chronic obstructive pulmonary disease

Будневский¹,

Овсянников²,

Чернов³

et al. 2014

Pulʹmonologiâ (Mosk.)

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SummaryAn acute exacerbation of chronic obstructive pulmonary disease (COPD) plays an important role in the disease progression and significantly reduces the patients' quality of life. The aim of this review was to summarize published findings about a possible role of biomarkers in diagnosis, manage ment and predicting outcomes in COPD patients. C reactive protein and serum amyloid A are the most investigated biomarkers in this field. Measurement of copeptin and proadrenomedullin may be useful in predicting short term outcomes. Biomarker oriented management of patients with acute exacerbation of COPD could be important for choosing medications.

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“…TNF-α is an important cytokine in COPD and is increased in persons with COPD (Karadag, Kirdar, Karul, & Ceylan, 2008;Koutsokera et al, 2009). TNF-α controls cellular migration and permeability and is important in the secretion of several cytokines.…”

Section: Inflammation and Copdmentioning

confidence: 99%

Stress and Inflammation: A Biobehavioral Approach for Nursing Research

Kang¹,

Rice

Park

et al. 2010

West J Nurs Res

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Despite known advantages, the use of biobehavioral approaches in nursing research remains limited. The purposes of this article are to (1) present applications of stress and inflammation in various health conditions as examples of biobehavioral concepts and (2) stimulate similar applications of biobehavioral concepts in future nursing research. Under a biobehavioral conceptual framework, studies on stress and selective inflammatory biomarkers in cardiovascular, cancer, and pulmonary health are reviewed and summarized. Inflammation underlies many diseases, and stress is a significant source of increased inflammation. Biobehavioral concepts of stress and inflammation are highly relevant to nursing research concerned with health-related issues. Diverse biobehavioral concepts are readily applicable and should be utilized in nursing research with children and adults. To stimulate further biobehavioral research, more training and resources for nurse scientists, more unified conceptual definitions and biobehavioral conceptual frameworks, rigorous and expanded methodologies, and more collaboration are essential.

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Clinical, functional and biochemical changes during recovery from COPD exacerbations

Cited by 70 publications

References 31 publications

Serum uric acid as a predictor of mortality and future exacerbations of COPD

Serum uric acid as a predictor of mortality and future exacerbations of COPD

Diagnostic values of biomarkers in acute exacerbation of chronic obstructive pulmonary disease

Stress and Inflammation: A Biobehavioral Approach for Nursing Research

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