Diagnostic values of biomarkers in acute exacerbation of chronic obstructive pulmonary disease

Будневский, А. В.; Овсянников, Евгений Сергеевич; Чернов, А. В.; Дробышева, Елена Сергеевна

doi:10.18093/0869-0189-2014-0-4-100-104

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…Согласно многочисленным отечественным и зарубежным исследованиям, уровень IL-6 в крови пациентов с ХОБЛ значительно повышается по сравнению со здоровыми людьми [1,12,24,44,46]. Следует отметить, что этот показатель растет по мере прогрессирования легочной патологии и коррелирует со степенью воспаления нижних дыхательных путей и снижением легочной функции [2,12,22,42,46]. Таким образом, в настоящее время уровень IL-6 в крови рассматривается в качестве маркера системного воспаления при ХОБЛ.…”

Section: The Review Presents the Known Pathophysiological Mechanisms unclassified

The Role of Interleukin-6 Signaling in Development of Systemic Inflammation in Chronic Obstructive Pulmonary Disease

Виткина¹,

Сидлецкая²,

Sidleckaya³

2018

Bulletin Physiology and Pathology of Respiration

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The review focuses on the role of interleukin-6 (IL-6) signaling in the development of a systemic inflammatory process in chronic obstructive pulmonary disease (COPD). In most researches the attention is paid to local inflammation in COPD. However, it is known that the pathology is characterized by a systemic inflammatory process, which is manifested in the increased levels of proinflammatory mediators in blood flow, and the study of the molecular mechanisms of its development is very important for the therapy of the disease. One of the key mediators of systemic inflammation is cytokine IL-6 which has pro- and antiinflammatory properties. Its effect on the cells is determined by the type of signaling. Nowadays three types of IL-6 signaling are identified: transsignaling, classical and cluster signaling. The review presents the known pathophysiological mechanisms of the development of systemic inflammation in COPD involving IL-6. As a proinflammatory cytokine, IL-6 performs the following functions: transmission of a signal on lung tissue damage, initiation of leukocyte migration into the inflammation site, inhibition of T-cell apoptosis into the inflammation site, influence on T helper differentiation, participation in pathophysiological reactions of development of emphysema and fibrosis. The significance of IL-6 transsignaling for the development of inflammation in COPD has been confirmed by many studies, while there are practically no works devoted to the study of classical IL-6 signaling in COPD. The data presented in the review indicate the need for further study of the role of different types of IL-6 signaling, especially classical signaling, in the regulation of systemic inflammation in COPD.

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Section: The Review Presents the Known Pathophysiological Mechanisms unclassified

The Role of Interleukin-6 Signaling in Development of Systemic Inflammation in Chronic Obstructive Pulmonary Disease

Виткина¹,

Сидлецкая²,

Sidleckaya³

2018

Bulletin Physiology and Pathology of Respiration

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Functional Status And Cytokine Profile Assessment In Patients With Chronic Obstructive Pulmonary Disease And Chronic Heart Failure

et al. 2022

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Objective — to evaluate the effect of chronic obstructive pulmonary disease (COPD) on the level of cytokines and the functional status of patients with chronic heart failure (CHF) with different categories of left ventricular ejection fraction. Methods — The study included 240 patients 40–70 years of age with CHF. All patients were divided into four groups: 69 CHF patients with preserved ejection fraction (CHFpEF), 91 CHF patients with reduced ejection fraction (CHFrEF), 36 COPD patients with CHFpEF and 44 COPD patients with CHFrEF. All participants underwent echocardiography, six-minute walk test (6MWT), the results of which were compared with the predicted six-minute walk distance: 6МWD (i). Additionally, we assessed the levels of NT-terminal fragment of pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP), IL-1β, IL-6, TNF-α, suppression of tumorigenicity 2 (ST2) in patient blood samples. Results — Patients with CHFpEF had higher levels of hs-CRP and proinflammatory cytokines as compared with patients with CHFrEF. The levels of NT-proBNP were higher in patients with COPD and CHF, compared with patients with CHF alone. A negative effect of COPD on the functional status of CHF patients with different EF values was established by the lower 6MWT values and 6MWD/6MWD ratio (i). An increase in the level of suppression of tumorigenicity 2 soluble forms (sST2) was noted in patients with COPD and CHF as compared with the isolated course of cardiac pathology patients. Conclusion — We established that unfavorable effect of COPD on patients with CHF was caused by disadvantageous values of NT-proBNP, ST2, 6MWT, and 6MWD/6MWD (i) ratio.

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Diagnostic value of C-reactive protein and proteinogram indicators as markers of systemic inflammation activity in mining and metallurgical workers with pneumoconiosis in combination with chronic obstructive pulmonary diseases

Rubtsov¹

2022

Dovkil Zdor

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Objective: We determined the diagnostic value of indicators of the content of C-reactive protein and proteinogram as the markers of systemic inflammation in workers of the mining and metallurgical industries with pneumoconiosis in combination with COPD in the system of measures aimed at timely diagnosis, treatment and prevention of this occupational lung pathology. Results: It has been established that in workers of the mining and metallurgical industry with pneumoconiosis in combination with COPD, the content of C-reactive protein is significantly increased, which is a predictor of the activation of the organism’s immune system, the occurrence of nonspecific reactions to prolonged bronchopulmonary inflammation with the formation of a predisposition to infectious complications.The revealed changes determine an unfavourable prognosis for further stimulation of the hyperproduction of pro-inflammatory triggers. The total protein content in the combination of pneumoconiosis and COPD corresponds to the physiological constants. The increase in the albumin content is a consequence of the chronicity of bronchopulmonary inflammation and a sign of the formation of dehydration processes of the organism of sick workers. A decrease in the content of the fraction of alpha-1-globulins, an increase in the content of the fraction of alpha-2-globulins is a sign of the imbalance of protein metabolism, and an increase in the content of beta-globulins (in absolute numbers) and a slight decrease in the content of gamma globulins are a sign of "compensation" for the exchange of large molecular globulin fractions. Thus, the study of the content of C-reactive protein and protein fractions in the peripheral blood among workers of the mining and metallurgical industry with pneumoconiosis in combination with COPD is an important link in assessing the activity of systemic inflammation within the framework of measures aimed at timely diagnosis, treatment, and prevention of this occupational diseases of lungs. Conclusions: Among the workers of mining and metallurgical industries with pneumoconiosis in combination with COPD, the high content of C-reactive protein causes significant activity of systemic inflammation with the stimulation of its mediators, determining a negative prognosis for development of the disease. The content of C-reactive protein in workers with pneumoconiosis stipulates a significant pro-inflammatory potential of this disease and allows you to consider it as an important sign of the reaction of the lymphoid system of lungs to the formation of coniotic changes and a tendency to damage the bronchial mucosa. The absence of significant differences in the indicators of the content of total protein and its fractions in sick workers is a sign of "compensation" of their metabolism during prolonged bronchopulmonary inflammation.

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Diagnostic values of biomarkers in acute exacerbation of chronic obstructive pulmonary disease

Cited by 4 publications

References 32 publications

The Role of Interleukin-6 Signaling in Development of Systemic Inflammation in Chronic Obstructive Pulmonary Disease

The Role of Interleukin-6 Signaling in Development of Systemic Inflammation in Chronic Obstructive Pulmonary Disease

Functional Status And Cytokine Profile Assessment In Patients With Chronic Obstructive Pulmonary Disease And Chronic Heart Failure

Diagnostic value of C-reactive protein and proteinogram indicators as markers of systemic inflammation activity in mining and metallurgical workers with pneumoconiosis in combination with chronic obstructive pulmonary diseases

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