Clinical Findings for Early Human Cases of Influenza A(H7N9) Virus Infection, Shanghai, China

Lu, Shuaiyao; Zheng, Yufang; Li, Tao; Hu, Yunwen; Liu, Xinian; Xi, Xiuhong; Chen, Qingguo; Wang, Qingle; Cao, Ye; Wang, Yanbing; Zhou, Ling; Lowrie, Douglas; Bao, Jing

doi:10.3201/eid.1907.130612

Cited by 14 publications

(13 citation statements)

References 9 publications

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“…Most H7N9 influenza patients exhibit general influenza-like symptoms, including fever and cough, and more than half of the infections typically progress to severe pneumonia, acute respiratory distress syndrome (ARDS), and multi-organ failure 8, 11, 19, 21, 23, 25, 27, 30–38 . Most H7N9 virus-infected patients possessed at least one underlying medical condition, such as chronic obstructive pulmonary disease (COPD), diabetes, hypertension, obesity, and/or chronic lung and heart disease 19, 21–23, 25, 26, 28, 31, 39, 40 , suggesting that these comorbidities may increase the risk of severe H7N9 virus infection.…”

Section: Epidemiology Of Human H7n9 Virus Infectionsmentioning

confidence: 99%

Pandemic potential of avian influenza A (H7N9) viruses

Watanabe¹,

Watanabe²,

Maher³

et al. 2014

Trends in Microbiology

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Avian influenza viruses rarely infect humans, but the recently emerged avian H7N9 influenza viruses have caused sporadic infections in humans in China, resulting in 440 confirmed cases with 122 fatalities as of May 16, 2014. In addition, epidemiologic surveys suggest that there have been asymptomatic or mild human infections with H7N9 viruses. These viruses replicate efficiently in mammals, show limited transmissibility in ferrets and guinea pigs, and possess mammalian-adapting amino acid changes that likely contribute to their ability to infect mammals. Here, we summarize the characteristic features of the novel H7N9 viruses and assess their pandemic potential.

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Section: Epidemiology Of Human H7n9 Virus Infectionsmentioning

confidence: 99%

Pandemic potential of avian influenza A (H7N9) viruses

Watanabe¹,

Watanabe²,

Maher³

et al. 2014

Trends in Microbiology

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“…The neuraminidase inhibitor oseltamivir was reported to be effective and safe for therapy of influenza A [ 5 ] and employed in a number of H7N9 cases. Although a number of cases were cured [ 6 , 7 ], oseltamivir was still invalid for a part of cases and the efficiency is still debatable [ 8 , 9 ]. Recently, Wu et al solved the structures for neuraminidases of A/Anhui/1/2013 (N9, R294) and A/Shanghai/1/2013 (N9, K294), which showed that the mutation of R294K could induce conformation changes and generate oseltamivir resistance through interfering with the binding of oseltamivir carboxylate [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking of Potential Inhibitors for Influenza H7N9

Zhao

Dong

et al. 2015

Computational and Mathematical Methods in Medicine

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As a new strain of virus emerged in 2013, avian influenza A (H7N9) virus is a threat to the public health, due to its high lethality and pathogenicity. Furthermore, H7N9 has already generated various mutations such as neuraminidase R294K mutation which could make the anti-influenza oseltamivir less effective or ineffective. In this regard, it is urgent to develop new effective anti-H7N9 drug. In this study, we used the general H7N9 neuraminidase and oseltamivir-resistant influenza virus neuraminidase as the acceptors and employed the small molecules including quercetin, chlorogenic acid, baicalein, and oleanolic acid as the donors to perform the molecular docking for exploring the binding abilities between these small molecules and neuraminidase. The results showed that quercetin, chlorogenic acid, oleanolic acid, and baicalein present oseltamivir-comparable high binding potentials with neuraminidase. Further analyses showed that R294K mutation in neuraminidase could remarkably decrease the binding energies for oseltamivir, while other small molecules showed stable binding abilities with mutated neuraminidase. Taken together, the molecular docking studies identified four potential inhibitors for neuraminidase of H7N9, which might be effective for the drug-resistant mutants.

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“… 2 Although previous studies have shown that H7N9 infection is often accompanied by multiple chronic conditions (hypertension, diabetes, chronic bronchitis, etc. ), 3 – 6 the most recent H7N9 epidemic seems to reveal a different increased risk of death in elderly patients with particular chronic underlying medical conditions (UMCs). 3 , 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

Impacts of age and gender at the risk of underlying medical conditions and death in patients with avian influenza A (H7N9): a meta-analysis study

Cheng

Zhao

Xie

et al. 2018

TCRM

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ObjectiveThe objective of our study was to conduct a series of analyses that examined the impacts of age and gender at the risk of underlying medical conditions (UMCs) and death in patients with influenza A (H7N9).MethodsWe began by searching for potentially relevant articles in English or Chinese before February 28, 2018. Additionally, we reviewed our own files and reference lists of articles identified by this search.ResultsThe association between death and UMCs was significant in H7N9 patients, with an OR of 1.49 (95% CI: 1.24–1.78). Subgroup analyses showed that having two or more UMCs of any type (OR: 2.24; P=0.044), chronic respiratory diseases (OR: 1.81; P=0.032), and chronic cardiovascular disease (OR: 1.63; P=0.013) had an association with increased fatality in H7N9 patients. Age (60 years or older) [adjusted OR (AOR): 1.86; P=0.032] and gender (male: AOR: 1.68, P=0.006; female: AOR: 1.88, P=0.044) were significantly associated with death in H7N9 patients with UMCs compared to H7N9 patients without any UMC. Stratification analyses found statistically significant increased death in H7N9 patients with UMCs who were 60 years of age and older (AOR: 2.72; P<0.001) and gender (male; AOR=1.64; P=0.033), compared to H7N9 patients without these respective conditions.ConclusionImpacts of age are substantial and significant at the risk of UMCs and death in H7N9 patients. This analysis did not find a significant difference in gender comparisons. Efforts should particularly focus on reducing fatality rates in patients with combined risks from UMCs and other significant impact factor such as age (60 years or older).

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Clinical Findings for Early Human Cases of Influenza A(H7N9) Virus Infection, Shanghai, China

Cited by 14 publications

References 9 publications

Pandemic potential of avian influenza A (H7N9) viruses

Pandemic potential of avian influenza A (H7N9) viruses

Molecular Docking of Potential Inhibitors for Influenza H7N9

Impacts of age and gender at the risk of underlying medical conditions and death in patients with avian influenza A (H7N9): a meta-analysis study

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