Clinical findings among young women with genital human papillomavirus infection

Mao, Constance; Hughes, James P.; Kiviat, Nancy B.; Kuypers, Jane; Lee, Shu Kuang; Adam, Diane E.; Koutsky, Laura A.

doi:10.1067/mob.2003.164

Cited by 80 publications

(62 citation statements)

References 19 publications

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“…The question remains whether BV and cervical HPV infection are simply related because there is a biologic interaction between them, or they are the expression of the promiscuity of women and their partners. The study of Mao et al [18] confirmed the positive correlation between BV and HPV infection and also reported that BV was found to occur simultaneously with or after HPV infection, rather than ante-dating acquisition of HPV. These results suggest that cervical HPV infection may favor changes in the vaginal milieu that enhance development of BV.…”

Section: Discussionsupporting

confidence: 68%

Relationship among bacterial vaginosis, local inflammatory response and presence of cervical intraepithelial neoplasia in women with and without human papilloma virus infection

Vesna

Basheska

Zlatka

et al. 2012

Korean J Obstet Gynecol

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Section: Discussionsupporting

confidence: 68%

Relationship among bacterial vaginosis, local inflammatory response and presence of cervical intraepithelial neoplasia in women with and without human papilloma virus infection

Vesna

Basheska

Zlatka

et al. 2012

Korean J Obstet Gynecol

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“…Here, using unbiased metagenomic sequencing we observed that alpha-papillomaviruses, which include the known oncogenic papillomavirus types, were more common in women with a bacterial community characterized by a decrease in Lactobacillus and an increase in anaerobic bacteria associated with bacterial vaginosis, such as Gardnerella [16]. This is consistent with other studies that show that persistent papillomavirus infection is associated with an increase in anaerobic bacteria [33,34]. Whether either member of this viral-bacterial correlate is causative, or whether each is simply present as a result of simultaneous exposure remains to be determined.…”

Section: Discussionsupporting

confidence: 80%

Metagenomic analysis of double-stranded DNA viruses in healthy adults

Wylie

Mihindukulasuriya²,

Zhou³

et al. 2014

BMC Biology

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Background: The Human Microbiome Project (HMP) was undertaken with the goal of defining microbial communities in and on the bodies of healthy individuals using high-throughput metagenomic sequencing analysis. The viruses present in these microbial communities, the 'human virome,' are an important aspect of the human microbiome that is particularly understudied in the absence of overt disease. We analyzed eukaryotic double-stranded DNA (dsDNA) viruses, together with dsDNA replicative intermediates of single-stranded DNA viruses, in metagenomic sequence data generated by the HMP. We studied 706 samples from 102 subjects were studied, with each subject sampled at up to five major body habitats: nose, skin, mouth, vagina, and stool. Fifty-one individuals had samples taken at two or three time points 30 to 359 days apart from at least one of the body habitats.

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“…There is no data within published literature to indicate that HPV infection affects the growth of G. vaginalis in vaginal flora. Some studies do, however, report a higher incidence of infection with G. vaginalis (Murta et al, 2000;Mao et al, 2003;Lippman et al, 2010) and Candida spp (Nogueres et al, 2010) when HPV infection is present.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and genotypic diversity of cervical human papillomavirus infection among women from an urban center in Brazil

Coser¹,

T²,

Simon³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Human papillomavirus (HPV) infection is a common viral sexually transmitted infection and the main cause of cervical cancer in women worldwide. Epidemiological data on the prevalence of HPV in a given population is essential for the establishment of effective prevention strategies. The aim of this study was to determine HPV prevalence in women who attended a public health service within an urban center in Brazil. Cervical samples were collected from 337 women recruited from a primary public health care clinic in the city of Cruz Alta located in Rio Grande do Sul, the were detected in 83 (72.8%) and 48 (42.1%) samples, respectively. Furthermore, a great diversity of HPV genotypes was observed (18 high-risk, 12 low-risk, and 1 indeterminate). The most commonly identified low-risk types were candHPV62 (7.9%) and 61 (5.3%), while the most common high-risk types were 16 and 33 (8.8% each). Abnormal cytology was observed in 10 (3.0%) women, 9 of which were infected with HPV. Of the remaining 327 women with normal cytology results, 107 (32.7%) were positive for HPV DNA. HPV infection was correlated with younger age (less than 40 years), a first Pap smear, and other vaginal infections.

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Clinical findings among young women with genital human papillomavirus infection

Cited by 80 publications

References 19 publications

Relationship among bacterial vaginosis, local inflammatory response and presence of cervical intraepithelial neoplasia in women with and without human papilloma virus infection

Relationship among bacterial vaginosis, local inflammatory response and presence of cervical intraepithelial neoplasia in women with and without human papilloma virus infection

Metagenomic analysis of double-stranded DNA viruses in healthy adults

Prevalence and genotypic diversity of cervical human papillomavirus infection among women from an urban center in Brazil

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