Relationship among bacterial vaginosis, local inflammatory response and presence of cervical intraepithelial neoplasia in women with and without human papilloma virus infection

Vesna, Antovska; Basheska, Neli; Zlatka, Grncarova; Natasha, Aleksioska

doi:10.5468/kjog.2012.55.7.468

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…The found association between bacterial vaginosis and intraepithelial lesions of the cervix in our study (p= 0.032) was also found in some previously published studies [24,28,[37][38][39]. In the study of Antovska et al bacterial vaginosis was more common in the subgroup of women with invasive squamous cell carcinoma of the uterine cervix (6.3%) than in the subgroup with low-grade squamous intraepithelial lesions of the uterine cervix (2.1%) [40].…”

Section: Discussionsupporting

confidence: 90%

Association Between Bacterial Vaginosis and Squamous Intraepithelial Lesions of the Uterine Cervix

Dabeski¹,

Danilovski²,

Antovska³

et al. 2016

Macedonian Medical Review

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Introduction. Bacterial vaginosis is polymicrobial, primarily anaerobic infection, previously called non-specific vaginitis or vaginitis accompanied by Gardne-rella vaginallis. It is a result of an imbalance between different types of bacteria in the vagina. The aim of the study was to determine the association between bacterial vaginosis and squamous intraepithelial lesions of the uterine cervix. Methods. This cross-sectional study was conducted in a series of 338 sexually active women with cytologicallly diagnosed squamous intraepithelial lesion of the uterine cervix at the University Clinic of Gynecology and Obstetrics in Skopje in the period from October 2014 to October 2015. The age of the patients ranged from 20 to 59 years (35±10.49). All women underwent cervical biopsy with endocervical curettage for histopathological analysis and cervical biopsy for detection and HPV typing. Criteria for diagnosis of bacterial vaginosis was the presence of ≥20% clue cells of ePapanicolaou smear. Results. Bacterial vaginosis was detected in 19.5% (66/338) of the examined women. The most affected was the young population under the age of 30 years. The results showed an association between bacterial vaginosis and squamous intraepithelial lesions of the uterine cervix (p=0.032). There was no association between bacterial vaginosis and the grade of lesion of the uterine cervix (p=0.118), nor with HPV infection (p=0.570). But, however an association was found between HPV infection and squamous intraepithelial lesions of the uterine cervix (p=0.001). Conclusion. The most common risk factor for squamous intraepithelial lesions of the uterine cervix are persistent high-risk HPV infections. Bacterial vaginosis is the most common co-infection.

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Section: Discussionsupporting

confidence: 90%

Association Between Bacterial Vaginosis and Squamous Intraepithelial Lesions of the Uterine Cervix

Dabeski¹,

Danilovski²,

Antovska³

et al. 2016

Macedonian Medical Review

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Subclinical isolation of Epstein—Barr viruses and immunity in women with genital herpes

Ermolenko¹,

Zakrevskaya²,

Zheltakova³

et al. 2017

Vestnik SPbSU. Medicine

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1 НИИ эпидемиологии и микробиологии им. Пастера, Российская Федерация, 197101, Санкт-Петербург, ул. Мира, 14 2 Детский научно-клинический центр инфекционных болезней Федерального медико-биологического агентства, Российская Федерация, 197022, Санкт-Петербург, ул. Профессора Попова, 9 3 Первый Санкт-Петербургский государственный медицинский университет им. академика И. П. Павлова, Российская Федерация, 197022, Санкт-Петербург, ул. Льва Толстого, 6-8Целью исследования явилось изучение частоты бессимптомного выделения вирусов Эпштейна-Барр (ВЭБ) у женщин с генитальным герпесом с рецидивирующим течением в зависимости от стадии инфекционного процесса и состава вагинальной микробиоты. Показано, что при тяжелом течении генитального герпеса указанный феномен отмечается как при рецидиве заболевания (28 % случаев), так и при ремиссии (18 % случаев). Этому способствует формирующийся у больных иммунный ответ по Тh2-типу. При среднетяжелом течении генитального герпеса во время ремиссии, но на фоне бактериального вагиноза, вирусы выделены в 23 % случаев, а после его лечения -в 8 %. Указанное объясняется и Тh2-типом иммунного ответа, и недостаточностью местного противовирусного иммунитета при бактериальном вагинозе. Показано, что снижение напряженности местного и общего противовирусного иммунного ответа способно включать механизм бессимптомного выделения вирусов Эпштейна-Барр. Библиогр. 23 назв. Ил. 6. Табл. 2.Ключевые слова: вирусы Эпштейна-Барр, генитальный герпес, бактериальный вагиноз, общий и местный иммунитет.

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Relationship among bacterial vaginosis, local inflammatory response and presence of cervical intraepithelial neoplasia in women with and without human papilloma virus infection

Cited by 2 publications

References 19 publications

Association Between Bacterial Vaginosis and Squamous Intraepithelial Lesions of the Uterine Cervix

Association Between Bacterial Vaginosis and Squamous Intraepithelial Lesions of the Uterine Cervix

Subclinical isolation of Epstein—Barr viruses and immunity in women with genital herpes

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