Clinical Features, Treatment, and Long-term Outcomes of Central Neurocytoma: A 20-Year Experience at a Single Center

Wang, Mengmeng; Zhou, Peizhi; Zhang, Shizhen; Liu, Xueyou; Lv, Liang; Wang, Zeming; Ye, Feng; Wang, Xiang; Jiang, Shu

doi:10.1016/j.wneu.2017.09.103

Cited by 30 publications

(46 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In that case, a second session surgery had to be performed. These results may be different from those published by Wang et al [6] who reported a gross total resection rate of 54% of the 63 patients included in their series. This discrepancy in the gross total resection rates may be attributed to the larger number of their studied patients' group.…”

Section: Discussioncontrasting

confidence: 96%

“…CNs were first described by Hassoun et al in 1982 [2]. They are generally slow-growing well-delineated WHO Grade II neuroepithelial intraventricular tumors that account for around 0.25 to 0.5% of all primary brain tumors and affect young adults (between 20 and 40 years) predominantly [3][4][5][6][7][8][9][10]. There have been less than 500 cases reported in the literature since its first description [11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Transcortical approach to lateral ventricular central neurocytomas: a case series and review of the literature

2018

View full text Add to dashboard Cite

Background: Central neurocytomas (CN) are relatively rare intrinsic brain tumors of an ectodermal origin that usually arise in the lateral ventricles close to the foramen of Monro and septum pellucidum. Surgical gross total resection is now considered the gold standard treatment for CNs. The choice of the most convenient approach (transcortical or transcallosal) remains controversial. This study was designed to assess the efficiency and safety of gross total resection using the transcortical approach in the treatment of patients with lateral ventricular central neurocytomas. Patients and methods: This is a retrospective observational study conducted on eight patients who underwent surgical treatment for a lateral ventricular tumor that had a postoperative histopathological diagnosis of central neurocytoma via the transcortical approach. The included patients were operated upon at Ain Shams University Hospitals between October 2012 and August 2017. The postoperative clinical data were analyzed for the assessment of changes in the initial data and for any procedure-related complications. Results: The current study included two males and six females (a total of eight patients) with a mean age of 24. Seventy-five years ranging from 12 to 34 years. The main presenting symptom was a persistent headache. The mean duration of symptoms prior to diagnosis was 2.625 months ranging from 1 to 6 months. Preoperatively, five patients had hydrocephalic changes due to obstruction of the cerebrospinal fluid pathways; however, none of them had a cerebrospinal fluid diversion prior to direct tumor attack. Gross total resection (radiologically proven) was achieved in six (75%) patients. One patient had an approach-related visual field defect and one patient had postoperative epilepsy that required long-term use of antiepileptic therapy. The mean postoperative follow-up duration was 26 months ranging from 6 to 60 months. Regarding functional outcome, by the end of the third postoperative month, seven patients could achieve a score of 5 according to the Glasgow Outcome Scale. Conclusion: The transcortical approach provides a safe and effective corridor for the achievement of gross total resection of lateral ventricular central neurocytomas with the main limitation of being less effective regarding the degree of resection in cases of bilateral tumors.

show abstract

Section: Discussioncontrasting

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Transcortical approach to lateral ventricular central neurocytomas: a case series and review of the literature

2018

View full text Add to dashboard Cite

show abstract

“…Mortality reported in 2-cases. The literature advocate that the use of adjuvant radiotherapy in not indicated after gross total resection, however, it can be offered for residual/recurrent tumor, though it remains matter of controversy [ 1 , 8 , 14 , 15 , 18 , 19 ]. In our center we follow the same guidelines.…”

Section: Discussionmentioning

confidence: 99%

Delving Inside the Enigmatic Central Neurocytoma: Electronic Hospital Database Retrieval

et al. 2020

View full text Add to dashboard Cite

Introduction: Central neurocytomas (CNCs) appear as a rare benign intraventricular lesions involving <0.5% of primary brain tumors. There are no consensus guidelines for the optimal management strategy, so that this entity still enigmatic. Aim: This review aims to highpoint the entity of central neurocytoma in patients managed by our department and the unique surgical considerations, to review the epidemiology and demographics in patients treated in our institution. Methods: This retrospective analysis was conducted by reviewing tall patients managed at King Hussein Medical Center (KHMC) and their medical records. Patient reports were retrieved from the electronic hospital database for a 14-year period (2004 _ 2018). The review was permitted by the Royal Medical Services Institutional ethics committee. As this study was a retrospective chart review, the requirement for consent was waived. Results: Study revealed 33- patients who had Central neurocytoma as the underlying cause for admission. Of the final population 42.4% of the patients were males. Mean age at diagnosis was 29.48±9.78 years. Two cases were extra-ventricular, to cases were anaplastc. Only one patient developed recurrence. Conclusion: We have one the large series of Central neurocytomas in literature. They are benign and total resection is feasible. New adjuvant therapies are flourishing. Supplementary studies are required clarify the cardinal factors responsible for its pathogenesis; diagnosis; and to consolidate management approaches protocol.

show abstract

“…However, due to the proximity of intraventricular vasculature and the basal ganglia, achieving total tumor resection is di cult, especially for large central neurocytomas. Additionally, the choice of surgical approach and whether postoperative radiotherapy should be applied are still controversial [5][6][7][8]. In this study, we retrospectively analyzed the treatment outcome of 29 intraventricular central neurocytoma patients.…”

Section: Introductionmentioning

confidence: 99%

Treatment experience of large intraventricular central neurocytoma: a retrospective cohort study

Zhang¹,

Yu²,

Hao³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Central neurocytoma is a rare intracranial tumor. Due to the limited number of reported cases, the treatment strategy for central neurocytomas, especially large central neurocytomas, remains controversial. This paper discusses our clinical experience in the treatment of large central neurocytomas.Methods: A retrospective analysis of 29 patients with intraventricular central neurocytomas diagnosed and treated by the same surgeon between April 2012 and September 2019 at the Neurosurgery Departments of Beijing Tiantan Hospital and Hainan General Hospital was performed. The clinical characteristics, treatment plans and prognoses of these patients were reviewed.Results: Among the 29 patients, the average age of onset was 31.93 (17-61) years, and the average maximum tumor diameter was 54.17 ± 15.62 mm. Twenty-three patients (79.3%) had an average maximum diameter greater than 50 mm. Twenty-seven patients (93.1%) underwent transcortical tumor resection. Twenty-seven patients (93.1%) underwent gross total tumor resection. Five patients (17.2%) received radiotherapy after the first operation, and 3 patients (10.3%) had tumor recurrence. None of the patients died.Conclusions: Surgical resection via transcortical fistulotomy is a reliable approach for removal of large central neurocytomas in the ventricle. Patients should be closely observed postoperatively, and MRI of the head should be performed regularly. If a tumor shows progression, then radiotherapy should be considered.

show abstract

Clinical Features, Treatment, and Long-term Outcomes of Central Neurocytoma: A 20-Year Experience at a Single Center

Cited by 30 publications

References 27 publications

Transcortical approach to lateral ventricular central neurocytomas: a case series and review of the literature

Transcortical approach to lateral ventricular central neurocytomas: a case series and review of the literature

Delving Inside the Enigmatic Central Neurocytoma: Electronic Hospital Database Retrieval

Treatment experience of large intraventricular central neurocytoma: a retrospective cohort study

Contact Info

Product

Resources

About