Delving Inside the Enigmatic Central Neurocytoma: Electronic Hospital Database Retrieval

Abstract

Introduction: Central neurocytomas (CNCs) appear as a rare benign intraventricular lesions involving <0.5% of primary brain tumors. There are no consensus guidelines for the optimal management strategy, so that this entity still enigmatic. Aim: This review aims to highpoint the entity of central neurocytoma in patients managed by our department and the unique surgical considerations, to review the epidemiology and demographics in patients treated in our institution. Methods: This retrospective analysis was conducted by reviewing tall patients managed at King Hussein Medical Center (KHMC) and their medical records. Patient reports were retrieved from the electronic hospital database for a 14-year period (2004 _ 2018). The review was permitted by the Royal Medical Services Institutional ethics committee. As this study was a retrospective chart review, the requirement for consent was waived. Results: Study revealed 33- patients who had Central neurocytoma as the underlying cause for admission. Of the final population 42.4% of the patients were males. Mean age at diagnosis was 29.48±9.78 years. Two cases were extra-ventricular, to cases were anaplastc. Only one patient developed recurrence. Conclusion: We have one the large series of Central neurocytomas in literature. They are benign and total resection is feasible. New adjuvant therapies are flourishing. Supplementary studies are required clarify the cardinal factors responsible for its pathogenesis; diagnosis; and to consolidate management approaches protocol.

Neurocitoma central: informe de 2 casos

“…Con anterioridad, era erróneamente etiquetado como oligodendroglioma intraventricular, siendo el principal diagnóstico diferencial microscopico. Cabe destacar, su origen neurocítico, su marcaje imunohistoquímico para neurona y que las mutaciones IDH y la codeleción 1p19q están ausentes, que son parámetros de diagnóstico característicos de los oligodendrogliomas [1][2][3][4].…”