Clinical Features of SARS-CoV-2 Infection in Patients Undergoing Solid-Organ Transplant: Baskent University Experience

Yüce, Gülbahar Darılmaz; Ulubay, Gaye; Tek, Korhan; Bozbas, Serife Savas; Erol, Çiğdem; Büyükaşık, Pırıl; Haberal, Kemal Murat; Arslan, Ayşe; Akçay, Müşerref Şule; Haberal, Mehmet

doi:10.6002/ect.2021.0361

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Overall, 590,375 enrolled patients were included (5,759 SOT recipients vs. 584,616 general populations). Six studies were prospective and twenty-five retrospective [ 4 , 5 , 6 , 7 , 9 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. Sixteen were conducted in Northern America (15 in USA and one in Canada), fourteen in Europe, and one in Asia.…”

Section: Resultsmentioning

confidence: 99%

Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis

Gatti

Rinaldi

Bussini

et al. 2022

Clinical Microbiology and Infection

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Section: Resultsmentioning

confidence: 99%

Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis

Gatti

Rinaldi

Bussini

et al. 2022

Clinical Microbiology and Infection

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“…Numerous studies have examined the impact of COVID-19 in solid organ transplant recipients. [5][6][7][8][9][10][11][12][13][14][15][16][17] These studies have consistently found that solid organ transplant recipients have a high rate of death and hospitalization from COVID-19. However, few studies have provided a comprehensive look at COVID-19 and its associated outcomes in all solid organ transplant types, across multiple waves of the COVID-19 pandemic, including 1-y into the Omicron era when patients had access to both vaccination and therapeutics.…”

mentioning

confidence: 99%

Comparison of COVID-19 Hospitalization and Death Between Solid Organ Transplant Recipients and the General Population in Canada, 2020–2022

Naylor,

Knoll,

Treleaven

et al. 2024

Transplantation Direct

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Background. Solid organ transplant recipients have a high risk of severe outcomes from SARS-CoV-2 infection. A comprehensive understanding of the impact of the COVID-19 pandemic across multiple waves in the solid organ transplant population and how this compares to the general population is limited. We conducted a population-based cohort study using linked administrative healthcare databases from Ontario, Canada to answer this question. Methods. We included 15 306 solid organ transplant recipients and 12 160 904 individuals from the general population. Our primary outcome was the rate (per 100 person-years) of severe COVID-19 (ie, hospitalization or death with a positive SARS-CoV-2 test) occurring between January 25, 2020, and November 30, 2022. Results. Compared with the general population, solid organ transplant recipients had almost a 6 times higher rate of severe COVID-19 (20.39 versus 3.44 per 100 person-years), with almost 5.5 times as high a rate of death alone (4.19 versus 0.77 per 100 person-years). Transplant recipients with severe COVID-19 were substantially younger (60.1 versus 66.5 y) and had more comorbidities. The rate of severe COVID-19 declined over time in the solid organ transplant population, with an incidence rate of 41.25 per 100 person-years in the first wave (January 25, 2020, to August 31, 2020) and 18.41 in the seventh wave (June 19, 2022, to November 30, 2022, Omicron era). Conclusions. Solid organ transplant recipients remain at high risk of severe outcomes when they are infected with SARS-CoV-2. Resources and strategies to mitigate the impact of SARS-CoV-2 exposure are needed in this vulnerable patient population.

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Evaluation of Living or Deceased Donor Candidates in Terms of COVID-19: Baskent University Experience

Arslan¹,

Azap²

2022

Exp Clin Transplant

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Clinical Features of SARS-CoV-2 Infection in Patients Undergoing Solid-Organ Transplant: Baskent University Experience

Cited by 3 publications

References 37 publications

Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis

Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis

Comparison of COVID-19 Hospitalization and Death Between Solid Organ Transplant Recipients and the General Population in Canada, 2020–2022

Evaluation of Living or Deceased Donor Candidates in Terms of COVID-19: Baskent University Experience

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