Clinical Features of Multiple Myeloma

Dancaster, C. P.; Hussain, Owais A.; Jackson, W. P. U.

doi:10.1136/pgmj.35.410.662

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…vaccine was much lower than that found in normal controls in all but one of the six myeloma patients. We did not, however, confirm the observations of Zinneman and Hall (1954) or of Dancaster et al (1959), who found no response whatever to T.A.B. in myeloma patients.…”

Section: Discussioncontrasting

confidence: 99%

“…Porges (1956) described cases of myeloma in which there was a deficiency of normal gamma-globulin as distinct from the abnormal protein, and he thought that the condition could be regarded as a secondary hypogammaglobulinaemia. Attempts to demonstrate any direct relationship between dysglobulinaemia and impaired antibody response have produced equivocal evidence, but the majority of the workers have claimed to show some correlation (Marks, 1953;Zinneman and Hall, 1954;Dancaster et al, 1959). This could not be confirmed by Lawson et al (1955), and it may be that the confusion is in part due to the small numbers of cases of myeloma usually available.…”

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Immune Responses in Myeloma

Linton¹,

Dunnigan²,

Thomson³

1963

BMJ

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Section: Discussioncontrasting

confidence: 99%

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confidence: 99%

Immune Responses in Myeloma

Linton¹,

Dunnigan²,

Thomson³

1963

BMJ

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Effect of Cytokine Genes in the Pathogenesis and on the Clinical Parameters for the Treatment of Multiple Myeloma

Haydaroglu

Balcı

Pehlıvan

et al. 2016

Immunological Investigations

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In this study, we aimed to explore the association among gene variants of five cytokines, tumor necrosis factor alpha (TNF-α), transforming growth factor beta-1 (TGF-β1), interferon gamma (IFN-γ), interleukin-6 (IL-6), and interleukin-10 (IL-10), and clinical parameters and prognosis in patients with multiple myeloma (MM) treated with novel therapeutic drugs in Turkish population for the first time except TNF-α. We analyzed five cytokine genes in 113 cases with MM and 113 healthy controls. Cytokine genotyping was performed by the polymerase chain reaction-sequence-specific primer method (PCR-SSP). AG genotype associated with high expression in TNF-α gene (-308) variant was found to be significantly higher (p = 0.019), and GG genotype associated with low expression in TNF-α gene (-308) variant was significantly lower in MM group as compared with controls (p = 0.012). IFN-γ (+874) variant TT genotype was increased (p = 0.037), and AA genotype was decreased (p = 0.002) in MM group in contrast to controls. IFN-γ (+874) T allele was higher in MM patients compared with controls (OR = 1.985, p = 0.000), while A allele was significantly lower (OR = 0.5037, p = 0.0005). Multivariate analysis revealed that factors associated with 5-year overall survival (OS) were only IPI III (RR = 1.630, p = 0.018) and thrombocytopenia (RR = 2.207, Cox p = 0.021), while 5-year event-free survival (EFS) was associated with IPI III (RR = 1.524, p = 0.022), thrombocytopenia (RR = 2.902, p = 0.002), APSCT treatment (RR = 1.729, p = 0.035), and female gender (RR = 0.435, p = 0.002) with negative prognostic values. Our results suggested that TNF-α gene (-308) AG genotype and IFN-γ (+874) TT genotype and T allele may have a role on MM, while other cytokines were not associated with the risk of MM.

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Myelomatosis Presenting with Acute Intestinal Obstruction

Abouna

1962

Postgraduate Medical Journal

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Ever since Kahler described myelomatosis in I889, some 44 years after the discovery by Dr. Bence Jones of the abnormal proteinuria frequently seen in this condition, many cases have now been reported in which this disease has first presented with an unusual clinical picture. Although gastro-intestinal discomfort, nausea, vomiting and melena have been seen in cases of myelomatosis, frank intestinal obstruction, as the only clinical manifestation of this disease, does not appear to have been reported in the English In view of this and of the unusual operative findings further investigations were performed: copyright.

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Clinical Features of Multiple Myeloma

Cited by 6 publications

References 15 publications

Immune Responses in Myeloma

Immune Responses in Myeloma

Effect of Cytokine Genes in the Pathogenesis and on the Clinical Parameters for the Treatment of Multiple Myeloma

Myelomatosis Presenting with Acute Intestinal Obstruction

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