Clinical Features of Infections and Colonization by Acinetobacter Genospecies 3

Abstract

Two hundred twenty-one isolates of Acinetobacter baumannii and 15 of Acinetobacter genospecies 3 (AG3) were consecutively collected in a 30-day period during the nationwide project GEIH-Ab2000. Nosocomial acquisition (P ‫؍‬ 0.01), intensive care unit admission (P ‫؍‬ 0.02), and antibiotic pressure (P ‫؍‬ 0.03) were observed to be lower in the AG3 group. AG3 isolates were more frequently implied in wound infections (P ‫؍‬ 0.05), while A. baumannii tended to be recovered from respiratory samples (P ‫؍‬ 0.08). To our knowledge, this is the first report analyzing the clinical differences among Acinetobacter genospecies, with our findings suggesting that clinical features of AG3 may not be equivalent to those traditionally described for A. baumannii.

Community-acquiredAcinetobacter baumannii: clinical characteristics, epidemiology and pathogenesis

“…A. pittii and A. nosocomialis are often associated with clinical outbreaks of disease and antibiotic resistance in healthcare institutions [8][9][10]. A. pittii has a high carriage rate on healthy individuals in the community, often at rates higher than A. baumannii [10][11][12]; however, we are unaware of any community-acquired infections being caused by A. pittii. Community-acquired infections caused by A. nosocomialis are rare, though equally as severe as CA-Ab, with only two cases being recently reported in the Northern Territory of Australia [7].…”

Identification of Acinetobacter Species Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry

“…With respect to clinical characteristics, A. baumannii has predominantly accounted for nosocomial infection outbreaks in intensive care units (ICU), although A. nosocomialis , A. pittii , and A. ursingii have also caused outbreaks [ 25 26 27 ]. The rates of ICU admissions (15.4% vs. 50.0%), hospital-acquired infections (76.9% vs. 97.2%), and mortality (16.7% vs. 58.6%) were significantly greater in the A. baumannii group than in the non- A. baumannii group [ 9 11 ]. Moreover, Park et al [ 28 ] found that A. baumannii infection was an independent predictor of mortality in patients with Acinetobacter bacteremia, a finding that further emphasizes the importance of correct species identification of Acinetobacter species.…”

“…The clinical features and antibiotic susceptibilities of A. baumannii are different from those of non- baumannii Acinetobacter species. A previous study on the clinical characteristics of Acinetobacter infections found that no cases of infection with non- baumannii Acinetobacter species aggravated to severe sepsis or septic shock [ 9 ]. The overall antimicrobial susceptibilities of non- baumannii Acinetobacter species have been much higher than those of A. baumannii .…”

“…The overall antimicrobial susceptibilities of non- baumannii Acinetobacter species have been much higher than those of A. baumannii . The median number of administered antibiotics was also lower in the non- baumannii group [ 9 10 11 ]. Therefore, the accurate identification of Acinetobacter species is clinically significant.…”

Draft Genome Sequence of an Acinetobacter Genomic Species 3 Strain Harboring a blaNDM-1 Gene

“…baumannii complex (ACB complex), as it is difficult to distinguish them from each other by phenotypic properties (4,12). Like A. baumannii, Acinetobacter genomic species 3 is responsible for both community-acquired and nosocomial infections (2,10). Intensive phylogenetic analysis has led recently to the proposal of Acinetobacter genomic species 3 as a novel species (Acinetobacter pittii) (11).…”