Clinical Features of Group B
            <i>Streptococcus</i>
            Prosthetic Joint Infections and Molecular Characterization of Isolates

Corvec, Stéphane; Illiaquer, Marina; Touchais, S.; Boutoille, David; Mee-Marquet, Nathalie van der; Quentin, Roland; Reynaud, Alain; Lepelletier, Didier; Bémer, Pascale

doi:10.1128/jcm.00581-10

Cited by 21 publications

(12 citation statements)

References 15 publications

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“…Of the CoNS, S. lugdunensis was the second most frequently isolated species after S. epidermidis, confirming its strong virulence, as reported previously (25). Concerning streptococcal infections, our study confirms the importance of Streptococcus agalactiae and shows the existence of true PJIs caused by the Streptococcus mitis and Streptococcus milleri groups (26). P. acnes infections represented 7% of monomicrobial anaerobic PJIs, which highlights its role in the pathogenicity of implant-associated infections (27).…”

Section: Discussionsupporting

confidence: 70%

Evaluation of 16S rRNA Gene PCR Sensitivity and Specificity for Diagnosis of Prosthetic Joint Infection: a Prospective Multicenter Cross-Sectional Study

Bémer¹,

et al. 2014

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There is no standard method for the diagnosis of prosthetic joint infection (PJI). The contribution of 16S rRNA gene PCR sequencing on a routine basis remains to be defined. We performed a prospective multicenter study to assess the contributions of 16S rRNA gene assays in PJI diagnosis. Over a 2-year period, all patients suspected to have PJIs and a few uninfected patients undergoing primary arthroplasty (control group) were included.

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Section: Discussionsupporting

confidence: 70%

Evaluation of 16S rRNA Gene PCR Sensitivity and Specificity for Diagnosis of Prosthetic Joint Infection: a Prospective Multicenter Cross-Sectional Study

Bémer¹,

et al. 2014

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“…Previous studies of streptococcal bone and joint infection have reviewed the clinical characteristics and the outcome of streptococcal arthritis or joint prosthesis infection by streptococcal groups classified by Lancefield and Sherman [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] . Only a few studies of streptococcal bone and joint infection with well-identified species have been reported [11] , [12] , [13] , [14] , [15] .…”

Section: Introductionmentioning

confidence: 99%

Clinical features and outcome of bone and joint infections with streptococcal involvement: 5-year experience of interregional reference centres in the south of France

Seng

Vernier

Gay

et al. 2016

New Microbes and New Infections

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Streptococcal bone and joint infections are less common than staphylococcal cases. Few studies have reported the cases with well-identified Streptococcus species. Their clinical features and prognosis are not clearly known to date. Moreover, no treatment regimen has yet been clarified. We reviewed the streptococcal bone and joint infection cases managed in our centres from January 2009 to December 2013. We described the epidemiology, clinical and microbiologic characteristics, treatment approach and outcome. Among the 93 cases, 83% of patients were men with a median age of 60 years, and 90% of patients had comorbidities or risk factors. Bacteraemia occurred in 14% of cases. Serious complications occurred in six patients, including severe sepsis (two cases) and infective endocarditis (two cases). Orthopaedic device infections were observed in 35% of cases, including 17 patients with internal osteosynthesis device infection, 14 with prosthetic joint infection and three with vertebral osteosynthesis device infection. The median time between orthopaedic device implantation and onset of infection was 447 days. Fourteen species of Streptococcus were identified, including 97 isolates using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and three isolates using molecular identification. The five most represented species included S. agalactiae (37%), S. dysgalactiae (12%), S. anginosus (11%), S. constellatus (10%) and S. pneumoniae (9%). Streptococci isolates were susceptible to amoxicillin, with the exception of one S. mitis isolate. Remission 1 year after the end of treatment was recorded in 83%. One patient died of infection; eight patients had infections that failed to respond to treatment; and seven patients experienced relapse. Twenty patients (22%) had an unfavourable functional outcome, including 19 amputations and one arthrodesis. Five significant prognostic factors associated with an unfavourable clinical outcome were identified, including peripheral neuropathy (p 0.009), peripheral arterial disease (p 0.019), diabetes mellitus (p 0.031), location in the femur (p 0.0036), location in the foot (p 0.0475), osteitis without an orthopaedic device (p 0.041) and infection caused by S. dysgalactiae (p 0.020). The rate of poor outcomes remains high despite the low number of Streptococcus isolates resistant to antibiotics. Some prognostic factors, such as the presence of S. dysgalactiae, are associated with an unfavourable clinical outcome. Antibiotic regimens of streptococcal bone and joint infections are not standardized and need to be further investigated.

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“…Streptococcus is a diverse genus that has a prominent role in human disease but causes Ͻ10% of joint arthroplasty infections. A number of beta-hemolytic Streptococcus species cause PJI, including Lancefield groups A (145-147), B (148)(149)(150)(151)(152)(153), C (154)(155)(156), and G (145,157,158). Streptococcus gallolyticus subsp.…”

Section: Causative Microorganismsmentioning

confidence: 99%

Prosthetic Joint Infection

2014

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SUMMARY Prosthetic joint infection (PJI) is a tremendous burden for individual patients as well as the global health care industry. While a small minority of joint arthroplasties will become infected, appropriate recognition and management are critical to preserve or restore adequate function and prevent excess morbidity. In this review, we describe the reported risk factors for and clinical manifestations of PJI. We discuss the pathogenesis of PJI and the numerous microorganisms that can cause this devastating infection. The recently proposed consensus definitions of PJI and approaches to accurate diagnosis are reviewed in detail. An overview of the treatment and prevention of this challenging condition is provided.

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Clinical Features of Group B Streptococcus Prosthetic Joint Infections and Molecular Characterization of Isolates

Cited by 21 publications

References 15 publications

Evaluation of 16S rRNA Gene PCR Sensitivity and Specificity for Diagnosis of Prosthetic Joint Infection: a Prospective Multicenter Cross-Sectional Study

Evaluation of 16S rRNA Gene PCR Sensitivity and Specificity for Diagnosis of Prosthetic Joint Infection: a Prospective Multicenter Cross-Sectional Study

Clinical features and outcome of bone and joint infections with streptococcal involvement: 5-year experience of interregional reference centres in the south of France

Prosthetic Joint Infection

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