“…Furthermore, our finding of high IL-18 levels accords with previous reports that showed increased IFN-g levels in schizophrenic patients (Miller et al, 2011), since IL-18 may induce IFN-g secretion (Felderhoff-Mueser et al, 2005). More broadly, many studies have reported elevated expression of IL-18 in autoimmune diseases, such as rheumatoid arthritis (Kawashima et al, 1996) and adult onset Still's disease (Kawashima et al, 1998). Moreover, the potential contribution of IL-18 to acute and chronic neuroprogression has been extensively investigated in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE; the animal model for MS).…”