Prognostic Significance of CYFRA21-1, CEA and Hemoglobin in Patients with Esophageal Squamous Cancer Undergoing Concurrent Chemoradiotherapy

Zhang, Haiqin; Wang, Ren-Ben; Huang, Yan; Zhao, Wei; Zhu, Kangshun; Jiang, Suping; Hu, Xi-gang; Yu, Jinming

doi:10.7314/apjcp.2012.13.1.199

Cited by 30 publications

(26 citation statements)

References 21 publications

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“…Another reason may be related to the diagnostic criteria of anemia. In many studies, a low HGB level was defined as a HGB level <130g/l in men and 120g/l in women [16,35]. age group [36].…”

Section: Discussionmentioning

confidence: 99%

Lower Mean Corpuscular Hemoglobin Concentration is Associated with Unfavorable Prognosis of Resected Lung Cancer

Zhang

et al. 2014

Future Oncol.

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“…Another reason may be related to the diagnostic criteria of anemia. In many studies, a low HGB level was defined as a HGB level <130g/l in men and 120g/l in women [16,35]. age group [36].…”

Section: Discussionmentioning

confidence: 99%

Lower Mean Corpuscular Hemoglobin Concentration is Associated with Unfavorable Prognosis of Resected Lung Cancer

Zhang

et al. 2014

Future Oncol.

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“…Aligned with these findings, other serum tumor markers have been accepted as valuable tools for prognosis and treatment monitoring over the last two decades. Serum tumor markers such as squamous cell carcinoma antigen (SCCA) (Deng et al, 2012), carcino-embryonic antigen (CEA) (Zhang et al, 2012), and lipid associated sialic acid (LASA) (Sawhney and Kumar, 2011) have been examined for their value in detecting head and neck and other cancers. However, due to their low sensitivity, these markers are not always clinically useful for the diagnosis of OSCC (Sawant et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Cytokines and tumor markers in potentially malignant disorders and oral squamous cell carcinoma: a pilot study

et al. 2013

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“…Previous studies have demonstrated the efficacy of CEA as a diagnostic and prognostic marker in patients with EC. 20 , 21 In our study, there were significant differences in CSS regarding CEA (45.1% vs 20.2%, P =0.001). However, CEA was not an independent prognostic factor in patients with ESCC ( P =0.818).…”

Section: Discussionmentioning

confidence: 43%

The combination of preoperative serum C-reactive protein and carcinoembryonic antigen is a useful prognostic factor in patients with esophageal squamous cell carcinoma: a combined ROC analysis

Huang¹,

Liu²,

Feng³

2015

OTT

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BackgroundThe prognostic value of inflammatory index in esophageal cancer (EC) has not been established. In the present study, therefore, we initially evaluated a novel prognostic system, named the COCC (COmbination of C-reactive protein [CRP] and carcinoembryonic antigen [CEA]), for making a prognosis in patients with esophageal squamous cell carcinoma (ESCC).MethodsA total of 327 patients with ESCC between January 2006 and December 2008 were included in this retrospective study. The COCC was calculated by combined CRP and CEA according to the logistic equation. The Kaplan–Meier method was used to calculate the cancer-specific survival (CSS), and the difference was assessed by the log-rank test. Cox regression analyses were performed to evaluate the prognostic factors.ResultsIn our study, COCC was defined as CRP +0.71 CEA according to the logistic equation. Receiver operating characteristic curves for CSS prediction were plotted to verify the optimum cutoff points for CRP, CEA, and COCC, which were 9.8 mg/L, 4.2 ng/mL, and 8.0, respectively. Patients with COCC ≤8.0 had a significantly better CSS than patients with COCC >8.0 (53.1% vs 15.3%, P<0.001). Multivariate analysis revealed that COCC was an independent prognostic factor in patients with ESCC (P=0.006). In addition, the area under the curve (AUC) was 0.722 for COCC, 0.645 for CRP, and 0.618 for CEA, indicating that COCC was superior to CRP or CEA for CSS prediction.ConclusionThe COCC is an independent prognostic factor in patients with ESCC. We conclude that COCC was superior to CRP or CEA as a more precise prognostic factor in patients with ESCC.

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Prognostic Significance of CYFRA21-1, CEA and Hemoglobin in Patients with Esophageal Squamous Cancer Undergoing Concurrent Chemoradiotherapy

Cited by 30 publications

References 21 publications

Lower Mean Corpuscular Hemoglobin Concentration is Associated with Unfavorable Prognosis of Resected Lung Cancer

Lower Mean Corpuscular Hemoglobin Concentration is Associated with Unfavorable Prognosis of Resected Lung Cancer

Cytokines and tumor markers in potentially malignant disorders and oral squamous cell carcinoma: a pilot study

The combination of preoperative serum C-reactive protein and carcinoembryonic antigen is a useful prognostic factor in patients with esophageal squamous cell carcinoma: a combined ROC analysis

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