Clinical features of chronic urticaria in aging population

Chuamanochan, Mati; Kulthanan, Kanokvalai; Tuchinda, Papapit; Chularojanamontri, Leena; Nuchkull, Piyavadee

doi:10.12932/ap0708

Cited by 5 publications

(27 citation statements)

References 17 publications

(19 reference statements)

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“…Several studies have demonstrated the usefulness of different clinical markers of disease severity, response to therapies and remission of the disease in CSU 89. Some data showed how age could be inversely associated with disease severity and improvement rates are significantly higher in patients <19 years old as compared to adults 89–91. Furthermore, it seems that the age of CSU patients significantly predicts the quality of life impairment assessed with the disease-specific quality of life instrument CU-Q2oL.…”

Section: Clinical Biomarkersmentioning

confidence: 99%

<p>Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications</p>

Puxeddu¹,

Petrelli²,

Angelotti³

et al. 2019

JAA

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Chronic urticaria (CU) is a mast cell-driven disease characterized by the development of wheals, angioedema, or both for more than 6 weeks. The two major sub-types are chronic spontaneous urticaria (CSU) and inducible urticaria. In the last decade different pathophysiological mechanisms, potentially responsible for the development of the disease, have been described. It is likely that the activation of mast cells and basophils in CSU can be the results of immune system dysregulation, activation of the inflammatory cascade, and of the extrinsic coagulation pathway. Some of the mediators involved in the pathophysiological mechanisms of CSU have recently been identified as potential biomarkers useful for the diagnosis, follow-up, and management of the disease, even if they are not yet available in clinical practice. Thus, in this review we discuss new insights in the mediators involved in the pathogenesis of CSU, highlighting their potential role as biomarkers in the activity and progression of the disease and response to therapies.

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Section: Clinical Biomarkersmentioning

confidence: 99%

<p>Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications</p>

Puxeddu¹,

Petrelli²,

Angelotti³

et al. 2019

JAA

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“…Four were prospective observational studies (collecting patient data from allergy clinics and/or secondary/tertiary care centers) [ 7 , 9 , 11 , 14 ], and four were retrospective observational studies (data were extracted from medical chart reviews, tertiary care centers and claims databases) [ 8 , 10 , 12 , 13 ]. The studies were conducted in the Netherlands [ 7 , 10 ], Israel [ 14 ], Italy [ 9 ], Thailand [ 8 , 11 , 12 ] and Korea [ 13 ]. Sample sizes ranged from 78 [ 7 ] to 228 patients [ 9 ] in prospective studies and from 153 [ 10 ] to 13,969 patients [ 13 ] in retrospective studies.…”

Section: Resultsmentioning

confidence: 99%

“…The definition of the disease was generally based on the guidelines as urticaria lasting at least 6 weeks with no identifiable trigger [ 8 , 9 , 11 , 12 ]. Certain studies presented details related to the inclusion and exclusion criteria of patients or disease severity levels.…”

Section: Resultsmentioning

confidence: 99%

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Clinical Remission of Chronic Spontaneous Urticaria (CSU): A Targeted Literature Review

Balp

Halliday

Severin

et al. 2021

Dermatol Ther (Heidelb)

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Introduction Chronic spontaneous (previously known as idiopathic) urticaria (CSU) is a chronic skin disease with the potential for natural remission. The objectives of this targeted literature review were to identify evidence on the clinical course of CSU, including remission rates, and to estimate cumulative remission rates for different time points. Methods Electronic databases (MEDLINE, MEDLINE-In Process, Embase, Web of Science, BIOSIS Previews and the Cochrane Library) and relevant conference proceedings were searched to identify studies involving patients with CSU aged ≥ 12 years that provide data on remission rates and disease duration. Observational studies with patient follow-ups of ≥ 1 year or review articles were included. Data extracted from five selected studies were used to run Kaplan–Meier (KM) analyses and best-fit distributions to calculate remission rates per 4-week period and weighted averages. Results Ten publications were included in this review. The proportion of patients achieving remission within year 1 ranged from 21 to 47%, while reported remission rate estimates at year 5 were 34% and 45%. Based on calculated 4-weekly remission rates, cumulative remission estimates ranged from 9 to 38% at year 1, from 29 to 71% at year 5 and from 52 to 93% at year 20. Cumulative weighted average estimates for the proportion of patients remitting at years 1, 5 and 20 were 17%, 45% and 73%, respectively. Conclusions Published evidence suggests that CSU is a self-limiting condition with variable disease severity and duration, apparently dependent on multiple factors. However, data sources differed in terms of definitions of disease severity and remission, as well as in conclusions on influencing factors. Further studies and uniform definitions are required. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-021-00641-6.

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“…2,3 Su prevalencia es de 0.5 a 5 % en el mundo, con predominio del sexo femenino (hasta 77 %) y un pico de incidencia entre los 20 y 40 años, con una duración promedio de dos a cinco años en 80 % de los casos. 4,5,6,7,8 La degranulación de la célula cebada es el evento central en la fisiopatología de la urticaria, la cual puede desencadenarse por múltiples estímulos que conllevan a la liberación de gránulos preformados (histamina, leucotrieno C4, prostaglandina D2 y factor activador de plaquetas) que dan origen al prurito, eritema y edema. 1,9 El diagnóstico es clínico pero la identificación de la causa implica un verdadero reto.…”

Section: Antecedentesunclassified

Alteraciones tiroideas en urticaria crónica espontánea

O’Farrill-Romanillos

Álvarez-Chávez

Xochihua-García

2019

RAM

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Artículo original 403 http://www.revistaalergia.mx Rev Alerg Mex. 2019;66(4):403-408 403 Thyroid disorders in spontaneous chronic urticaria Alteraciones tiroideas en urticaria crónica espontánea Este artículo debe citarse como: O'Farrill-Romanillos PM, Álvarez-Chávez FE, Xochihua-García JJ. Alteraciones tiroideas en urticaria crónica espontánea. Rev Alerg Mex. 2019;66(4):403-408 AbstractBackground: Chronic spontaneous urticaria (CSU) is linked to thyroid disease in up to 54%, with predominance of hypothyroidism. Objective: To describe the impairments of the thyroid function in patients with CSU in a third level of care. Methods: A cross-sectional, observational, and descriptive study in which we have included men and women over 18-year-old with CSU; in which TSH and free T4 were quantified. According to the results, they were classified as euthyroid, hyperthyroid, and hypothyroid; in the latter ones, the presence of antithyroid antibodies was intentionally sought. The demographic and biochemical characteristics of the results were assessed. Results: The clinical characteristics of 127 patients with CSU were analyzed. Women accounted for 78%. The average age was 44.5 ± 15.1 years. Impairments of the thyroid function were identified in 50 patients (39%), and subclinical hypothyroidism (SH) occurred in 41 (82%) of them; patients with hyperthyroidism were not found. Of the patients with hypothyroidism, 14 (28%) presented positive antibodies; all of them were women. Conclusions: More than a third of the analyzed patients with CSU presented impairments of the thyroid function; subclinical hypothyroidism (SH) was more common. The importance of identifying this entity lies in the possibility of a multidisciplinary treatment with endocrinology. Subsequent studies may establish whether the presence of hypothyroidism influences the activity of CSU.

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Clinical features of chronic urticaria in aging population

Abstract: Our study showed that CU in aging patients was uncommon (4.1%). Aging patients with CU seemed to have shorter disease duration and higher percentages of autoantibodies than non-aging patients with CU without a statistically significant difference.

Cited by 5 publications

References 17 publications

<p>Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications</p>

<p>Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications</p>

Clinical Remission of Chronic Spontaneous Urticaria (CSU): A Targeted Literature Review

Alteraciones tiroideas en urticaria crónica espontánea

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