Alteraciones tiroideas en urticaria crónica espontánea

Abstract

Artículo original 403 http://www.revistaalergia.mx Rev Alerg Mex. 2019;66(4):403-408 403 Thyroid disorders in spontaneous chronic urticaria Alteraciones tiroideas en urticaria crónica espontánea Este artículo debe citarse como: O'Farrill-Romanillos PM, Álvarez-Chávez FE, Xochihua-García JJ. Alteraciones tiroideas en urticaria crónica espontánea. Rev Alerg Mex. 2019;66(4):403-408 AbstractBackground: Chronic spontaneous urticaria (CSU) is linked to thyroid disease in up to 54%, with predominance of hypothyroidism. Objective: To describe the impairments of the thyroid function in patients with CSU in a third level of care. Methods: A cross-sectional, observational, and descriptive study in which we have included men and women over 18-year-old with CSU; in which TSH and free T4 were quantified. According to the results, they were classified as euthyroid, hyperthyroid, and hypothyroid; in the latter ones, the presence of antithyroid antibodies was intentionally sought. The demographic and biochemical characteristics of the results were assessed. Results: The clinical characteristics of 127 patients with CSU were analyzed. Women accounted for 78%. The average age was 44.5 ± 15.1 years. Impairments of the thyroid function were identified in 50 patients (39%), and subclinical hypothyroidism (SH) occurred in 41 (82%) of them; patients with hyperthyroidism were not found. Of the patients with hypothyroidism, 14 (28%) presented positive antibodies; all of them were women. Conclusions: More than a third of the analyzed patients with CSU presented impairments of the thyroid function; subclinical hypothyroidism (SH) was more common. The importance of identifying this entity lies in the possibility of a multidisciplinary treatment with endocrinology. Subsequent studies may establish whether the presence of hypothyroidism influences the activity of CSU.

Study on Autoimmune Thyroid Disorders in Chronic Spontaneous Urticaria at a Tertiary Care Central Rural Hospital in India

“…The statistical analysis yielded a t-value of 2.19 and a p-value of 0.034 for the two groups. This finding is in contrast to a prior study by O'farrill-Romanillos et al (2019) [ 13 ], which indicated that up to 54% of individuals with chronic spontaneous urticaria (CSU) exhibited a correlation with thyroid disease. Our study also found a significant result for anti-thyroperoxidase antibodies in both the cases and controls.…”

Profile of patients with chronic spontaneous urticaria treated with omalizumab in Chapecó, south of Brazil

“…As for anxiety, the rate of patients is similar to the study above. The study by Farril-Romanillos et al 15 (2019) found better results than this study in relation to the association of CSU with hypothyroidism, with 82% of the patients studied having both diseases. However, 28% of these patients had positive antibodies and were all women, which also differs from ours, in which 2 patients (5.9%) were men.…”

“…However, 28% of these patients had positive antibodies and were all women, which also differs from ours, in which 2 patients (5.9%) were men. 15 This association between CSU and hypothyroidism occurs because mast cells are activated in urticaria and are responsible for releasing inflammatory mediators such as histamine, mainly due to the binding of various types of IgE antibodies, including anti-thyroperoxidase IgE (anti-TPO) to their surface. These antibodies sensitize mast cells and induce degranulation after exposure to the specific circulating antigen, and anti-TPO are the same as those produced against the thyroid in diseases that cause hypothyroidism, in which they are released as a result of autoimmune damage to thyroid.…”