Clinical Features of Antinuclear Antibody-positive Patients with Atopic Dermatitis

Higashi, Naoyuki; Niimi, Yayoi; Aoki, Mikako; Kawana, Seiji

doi:10.1272/jnms.76.300

Cited by 14 publications

(19 citation statements)

References 27 publications

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“…11,14,15,19 In contrast to our results, Higashi et al reported that 19% of patients with AD had ANA at titers ranging from 1:40 to 1:640, with a remarkable difference between patients with AD and controls. ANA positivity in patients with AD has varied widely in earlier reports, mainly owing to differences in the age of studied individuals.…”

Section: Discussioncontrasting

confidence: 99%

“…During exacerbation of skin manifestations, IgE autoantibody levels have been shown to be increased, 10 which might be partly due to increased apoptosis and release of autoantigens from keratinocytes. 11,14,15 In our earlier studies we have also demonstrated a lower prevalence of ANA together with a lower prevalence of atopy in Estonian adults when compared to Swedish adults. Moreover, AD has a pattern of relapsing-remitting disease, similar to chronic autoimmune diseases.…”

Section: Introductionsupporting

confidence: 56%

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Antinuclear antibodies in atopic dermatitis: a cross‐sectional study on 346 children

et al. 2014

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No significant differences were observed between AD and the control group, or between different subtypes of AD in ANA prevalence. In both groups, ANA frequency increased with age, but in patients with AD, ANA had a tendency to appear earlier. Therefore, active AD during the early years of life could dispose selected patients towards earlier development of systemic autoreactivity and stress the need for regular follow-up of patients with ANA-positive AD.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionsupporting

confidence: 56%

Antinuclear antibodies in atopic dermatitis: a cross‐sectional study on 346 children

et al. 2014

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“…Furthermore, titre of ANA were not significantly higher in patients with severe AD or severe facial AD than in other patients. The prevalence of ANAs generally increases with age …”

Section: Evidence Of a Link From The Literaturementioning

confidence: 99%

“…The prevalence of ANAs generally increases with age. 35 Controversial data on the role of non-allergen-specific Abs in atopic dermatitis aimed also some authors to investigate the occurrence of the antiphospholipid Abs (anticardiolipin, and anti-b2-glycoprotein I) in children with AD.…”

Section: Evidence Of a Link From The Literaturementioning

confidence: 99%

Autoimmunity in atopic dermatitis: Biomarker or simply epiphenomenon?

Cipriani

Ricci

Leoni

et al. 2014

The Journal of Dermatology

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The idea that a mechanism of autoimmunity could play a role in the pathogenesis of atopic dermatitis gained support from the observation that patients with atopic dermatitis display IgE reactivity to a variety of human protein antigens, several of which have been characterized at molecular level. A broad spectrum of at least 140 IgE-binding self-antigens associated with atopic dermatitis has been demonstrated; they might promote, perpetuate, or both, skin inflammation by binding IgE antibodies or activating specific T cells. Even if the presence of autoreactivity seems to be associated with the severity of the disease and may be used as a parameter reflecting chronic tissue damage, at the state of art the role of autoimmunity in atopic dermatitis is far from clear. Data from the literature show that the use of autoantibodies as biomarkers of atopic dermatitis are still limited by the evidence that the epiphenomenon of autoreactivity is detectable only in a percentage of patients and that the involved selfallergens often are not the same; further longitudinal case-control studies are needed to investigate and to clarify the pathogenethic role of autoimmunity in the course of atopic dermatitis.

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“…For example, autoimmune abnormalities are frequently found in association with allergies [3] or even in normal patient populations [4,5], yet, even if just sub-clinical, have been associated with reproductive problems, including infertility, miscarriage risk [6,7] and complications of pregnancy, such a premature labor and preeclampsia/ eclampsia [8,9]. …”

Section: Introductionmentioning

confidence: 99%

Some aspects of interactivity between endocrine and immune systems required for successful reproduction

Weghofer

Himaya

Kushnir

et al. 2015

Reprod Biol Endocrinol

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BackgroundIn successful reproduction, endocrine and immune systems closely interact. We here attempt to further elucidate the relationship between androgen levels, systemic activation of the immune system and reproductive success in infertile women, utilizing 2 distinct infertile patient cohorts.MethodsIn Group 1, we investigated 322 women (ages 38.6 +/− 5.4 years) at initial presentation; in Group 2 125 women undergoing in vitro fertilization (169 IVF cycles, ages 38.9 +/− 5.5 years). In Group 1, we assessed androgens and an immune panel, previously demonstrated to discriminate between activated quiescent immune systems; in Group 2, utilizing the same immune panel, we investigated whether immune system activation relates to embryo quality in IVF cycles.ResultsNo individual immune test within the immune panel was associated with androgen levels. The total/free testosterone ratio (TT/FT) was, however, significantly associated with presence of gammopathies (in IgG, IgM, IgA, IgE; P = 0.026). Surprisingly, immune system activation was associated with significantly improved embryo quality (P = 0.008), a finding persistent after adjustment for age and repeat IVF cycles (P = 0.006).ConclusionsAssociation of immune system activation with improved embryo quality concurs with previously reported immune activation in association with normal functional ovarian reserve (FOR) and normal androgen levels, while, counter intuitively, hypoandrogenism and low FOR are associated with lack of immune system activation. Mild immune system activation, therefore, likely appears essential for establishment of pregnancy, and may be regulated by androgens.

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Clinical Features of Antinuclear Antibody-positive Patients with Atopic Dermatitis

Cited by 14 publications

References 27 publications

Antinuclear antibodies in atopic dermatitis: a cross‐sectional study on 346 children

Antinuclear antibodies in atopic dermatitis: a cross‐sectional study on 346 children

Autoimmunity in atopic dermatitis: Biomarker or simply epiphenomenon?

Some aspects of interactivity between endocrine and immune systems required for successful reproduction

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