Antinuclear antibodies in atopic dermatitis: a cross‐sectional study on 346 children

Ress, Krista; Metsküla, Kaja; Annus, Triine; Putnik, Goran D.; Lepik, Kristi; Luts, Katrin; Uibo, Oivi; Uibo, Raivo

doi:10.1111/ijd.12535

Cited by 6 publications

(5 citation statements)

References 23 publications

(54 reference statements)

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“…Understanding the contribution of IgE autoantibodies in the pathophysiology of atopic dermatitis, knowing the targets, and studying the correlation between auto-IgE and the severity of the disease will lead to the prompt diagnosis and individualized management of atopic dermatitis and possible autoimmune comorbidities [ 65 , 66 ].…”

Section: Extra-cutaneous Clinical Manifestationsmentioning

confidence: 99%

Atopic Dermatitis—Beyond the Skin

et al. 2021

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Atopic dermatitis is a chronic inflammatory disease that can arise during the first months of life or at maturity and have a significant negative impact on the quality of life. The main pathogenic mechanism is the breakdown of cutaneous barrier integrity, which is associated with systemic inflammatory immunologic disorders. Atopic dermatitis involves numerous immunologic, allergic, respiratory, and ophthalmologic comorbidities that develop through similar intricate pathogenic phenomena. The atopic march represents the evolution in time of various allergic diseases, of which food allergies often cause the first manifestations of atopy, even from a very young age. Chronic inflammation translated through specific markers, next to increased immunoglobulin E (IgE) serum levels and heterogenous clinical manifestations, argue for the inclusion of atopic dermatitis in the systemic disease category.

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Section: Extra-cutaneous Clinical Manifestationsmentioning

confidence: 99%

Atopic Dermatitis—Beyond the Skin

et al. 2021

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“…Autoreactivity may develop in early infancy [ 20 ] and atopy in early childhood may increase the development of autoimmune diseases later in life [ 20 , 26 , 28 ]. In a cross-sectional study including 346 children with active AD and 117 controls antinuclear antibodies (ANA) have been found in both groups, which increased with age [ 40 ]. Although not significantly different, in children with AD the ANA antibodies had a tendency to appear earlier, suggesting that active AD in early infancy can lead to earlier development of systemic autoreactivity [ 40 ].…”

Section: Ige Autoreactivity In Atopic Dermatitismentioning

confidence: 99%

IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis

Badloe

Vriese

Coolens

et al. 2020

Clin Transl Allergy

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The pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management. Immunoglobulins E (IgE) against human skin epitopes (IgE autoantibodies) are thought to play a role in disease progression and prolongation. These antibodies have been described in patients with severe and chronic AD, suggesting a progression from allergic inflammation to severe autoimmune processes against the skin. This review provides a summary of the current knowledge and gaps on IgE autoreactivity and self-reactive T cells in children and adults with AD based on a systematic search. Currently, the clinical relevance and the pathomechanism of IgE autoantibodies in AD needs to be further investigated. Additionally, it is unknown whether the presence of IgE autoantibodies in patients with AD is an epiphenomenon or a disease endotype. However, increased knowledge on the clinical relevance and the pathophysiologic role of IgE autoantibodies and self-reactive T cells in AD can have consequences for diagnosis and treatment. Responses to the current available treatments can be used for better understanding of the pathways and may shed new lights on the treatment options for patients with AD and autoreactivity against skin epitopes. To conclude, IgE autoantibodies and self-reactive T cells can contribute to the pathophysiology of AD based on the body of evidence in literature. However, many questions remain open. Future studies on autoreactivity in AD should especially focus on the clinical relevance, the contribution to the disease progression and chronicity on cellular level, the onset and therapeutic strategies.

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“…Pooling data from these studies showed a significantly higher frequency of ANA positivity in AD patients (OR: 2.18, 95% [1.31–3.64}) [ 4 ]. The most recent study looking for the prevalence of ANA in children by immunofluorescence showed that ANA were detectable at a younger age in AD than in healthy controls [ 49 ]. Evidence of autoreactivity in AD is supported by an increased prevalence of autoreactive CD4+ and CD8+ T cells from the blood and the skin of AD patients [ 28 ].…”

Section: Atopic Dermatitis: a Multifactorial Pathogenesismentioning

confidence: 99%

IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?

Pellefigues

2020

Antibodies

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Atopic dermatitis (AD) is a common skin disease affecting 20% of the population beginning usually before one year of age. It is associated with the emergence of allergen-specific IgE, but also with autoreactive IgE, whose function remain elusive. This review discusses current knowledge relevant to the mechanisms, which leads to the secretion of autoreactive IgE and to the potential function of these antibodies in AD. Multiple autoantigens have been described to elicit an IgE-dependent response in this context. This IgE autoimmunity starts in infancy and is associated with disease severity. Furthermore, the overall prevalence of autoreactive IgE to multiple auto-antigens is high in AD patients. IgE-antigen complexes can promote a facilitated antigen presentation, a skewing of the adaptive response toward type 2 immunity, and a chronic skin barrier dysfunction and inflammation in patients or AD models. In AD, skin barrier defects and the atopic immune environment facilitate allergen sensitization and the development of other IgE-mediated allergic diseases in a process called the atopic march. AD is also associated epidemiologically with several autoimmune diseases showing autoreactive IgE secretion. Thus, a potential outcome of IgE autoreactivity in AD could be the development of further autoimmune diseases.

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Antinuclear antibodies in atopic dermatitis: a cross‐sectional study on 346 children

Cited by 6 publications

References 23 publications

Atopic Dermatitis—Beyond the Skin

Atopic Dermatitis—Beyond the Skin

IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis

IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?

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