Clinical Features in Children Hospitalized during the 2005 Epidemic of Japanese Encephalitis in Uttar Pradesh, India

Abstract

Clinical features of Japanese encephalitis were severe. Derangements in liver function and thrombocytopenia were found in a significant proportion of patients. These findings were not highlighted during earlier epidemics of the illness and could suggest a possible mutation of the virus towards other flaviviruses.

Trend of Japanese encephalitis in North India: evidence from thirty-eight acute encephalitis cases and appraisal of niceties

“…Our pathological investigations revealed marked pleocytosis in cerebrospinal fluid and peripheral leucocytosis with mild anaemia, which is in accordance with earlier studies done by Kumar et al [16] in the same area. In CSF the elevated level of cells and alteration of protein level indicates penetration of the blood-brain barrier.…”

“…The mild anaemia may be because a result of MDF-induced hyperferretimia in serum [18]. The malfunctioning of the liver and kidney reported by Kumar et al [16], may be caused by replication of the virus in these organs [19]. Presence of virus in CSF from most of the fatal cases might suggest that the virus is actively multiplying in the central nervous system.…”

Clinical Profile and Outcome of Japanese Encephalitis in children Admitted with acute Encephalitis Syndrome in a tertiary Care hospital in Gaya, India

“…In our study, children mostly affected were from rural areas (85%) and belong to low socioeconomic group (72%). This correlated well with the earlier studies where the patients were children of farmers or farm laborers of low socioeconomic group residing in rural areas (13)(14) . This may be due to favorable epidemiological factors like presence of water logged paddy field supporting profuse breeding of vector mosquitoes, piggeries in close proximity to residence, nonuse of bed nets and outdoor playing habits of children.…”

Original Research Article: Clinical Profile and Outcome of Patients with Acute Encephalitis Syndrome in a Tertiary Care Hospital, Assam, India.

“…Our study also indicates that patients mostly affected were from rural areas of Assam (93.4%) and belong to low socioeconomic group. Similar observations were made by Kakoti G et al (2013) 90% in upper Assam and Kumar R at el (2006) in Uttar Pradesh, India (10,11). In month wise distribution of cases , (78.3%) patients were observed in the month of July ,August , September and October suggesting peak incidence in monsoon and post monsoon period.…”