Clinical features, Epidemiology, Autoantibody status, HLA Haplotypes and Genetic Mechanisms of Type 1 diabetes mellitus among Children in Qatar

Haris, Basma; Ahmed, Ikhlak; Syed, Najeeb; Almabrazi, Hakeem; Saraswathi, Saras; Al‐Khawaga, Sara; Saeed, Amira; Mundekkadan, Shihab; Idris, Mohamed Na; Sharari, Sanaa; Hawari, Iman; Hamed, Noor; Afyouni, Houda; Abdel-Karim, Tasneem; Mohammed, Shayma; Khalifa, Amal; Al-Maadheed, Maryam; Zyoud, Mahmoud; Shamekh, Ahmed; Elawwa, Ahmed; Al‐Khalaf, Fawziya; Tatari-Calderone, Zohreh; Petrovski, Goran; Hussain, Khalid

doi:10.21203/rs.3.rs-244766/v1

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…The Glutamic Acid Decarboxylase antibodies were sdetected in 90.3% of children with T1DM. This GAD65 prevalence was higher than the other studies in Saudi Arabia (84,4%) (Al-Alwan et al, 2012), Sudan (77.5%) (Mahdi et al, 2019), Qatar (59,7%) (Haris et al, 2021), and India (53%) (Vipin et al, 2021). Zinc Transporter-8 antibody prevalence in T1DM children in this study was 77,4%.…”

Section: Discussioncontrasting

confidence: 58%

Analysis of the ZNT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptides in Indonesian children with type 1 diabetes mellitus

Rochmah¹,

Faizi²,

Hisbiyah³

et al. 2022

ijhs

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Autoimmune reaction in Type 1 Diabetes Mellitus (T1DM) is caused by genetic and environmental factors. The genes HLA-DQA1 and HLA-DQB1 are strongly associated with T1DM. Other established markers of T1DM were Zinc Transporter 8 Antibody (ZnT8), Glutamic Acid Decarboxylase Antibody-65 (GAD65), and C-peptide. This study aims to analyze ZnT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptide in Indonesian children with T1DM. A cross-sectional study of T1DM children was conducted in Dr. Soetomo Hospital, Indonesia. ZnT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptide were examined with an ELISA kit. Mann-Whitney test was performed with a significant value of p<0.05. A total of 62 participants consisting of 31 children for each group were enrolled. The prevalence of ZnT8, GAD65, and C-peptide in T1DM patients was 77.4%, 90.3%, and 87.1%. There are 74% of T1DM children had two positive antibodies and 55% had two positive HLA peptides. There was no difference in HLA-DQA1 and HLA-DQB1 peptides between T1DM and control groups (p=0.12; p=0.19). Meanwhile, the comparison between ZnT8, GAD65, and C-Peptide values between T1DM and control groups shows a significant difference (p<0.05). HLA-DQA1 peptide value was higher in T1DM children and HLA-DQB1 peptide value was higher in non-T1DM children.

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Section: Discussioncontrasting

confidence: 58%

Analysis of the ZNT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptides in Indonesian children with type 1 diabetes mellitus

Rochmah¹,

Faizi²,

Hisbiyah³

et al. 2022

ijhs

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show abstract

“…In general, 5-10% of the diabetes cases in the society are T1DM cases. The prevalence of T1DM in childhood differs between countries (regions) [3,4]. Although there are many factors that predispose children to chronic complications of diabetes, the strongest predictor of diabetes is glycemic control.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of vitamin D, vitamin B12 and Hemoglobin HbA1c levels in patients with type 1 diabetes mellitus

Yücel¹,

Bayır²,

Yı̇ldırım³

2022

Med-Science

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We aimed to evaluate the Vitamin D, Vitamin B12 and Hemoglobin A1c Levels in patients with T1DM. This study is a retrospective cross-sectional study. We classified patients as <7.0% (good glycemic control) and ≥7% (poor glycemic control) based on HbA1c levels. Moreover, we divided the patients into four groups based on serum vitamin D concentrations. This study included 468 patients (257 females and 211 males) with T1DM. The present study revealed that the prevalence of vitamin D deficiency among children with T1DM was very high (49.57%). We found that the vitamin D, vitamin B12, ferritin, HGB and RBC levels were significantly lower in women than in men. The overall prevalence of poor glycemic control was 6.4%. When the groups we divided according to HbA1c levels were compared; we found that the fasting blood glucose and vitamin B12 were significantly lower, while insulin and Mg levels were significantly higher in the good glycemic control group compared to the poor glycemic control group. We found that as vitamin D increases, HbA1c, insulin and creatinine levels decrease, and vitamin B12 levels increases. The negative correlation of vitamin D levels with insulin levels (r:-0.320, p<0.01) and HbA1c levels (r:-0.187, p<0.01) was statistically significant . Our findings showed that, keeping the vitamin D levels high in T1DM patients is important in regulation of glycemic control. Considering the frequency of pernicious anemia in patients with T1DM, it is important to follow vitamin D, vitamin B12 and HbA1c levels in these patients.

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Clinical features, Epidemiology, Autoantibody status, HLA Haplotypes and Genetic Mechanisms of Type 1 diabetes mellitus among Children in Qatar

Cited by 2 publications

References 20 publications

Analysis of the ZNT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptides in Indonesian children with type 1 diabetes mellitus

Analysis of the ZNT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptides in Indonesian children with type 1 diabetes mellitus

Evaluation of vitamin D, vitamin B12 and Hemoglobin HbA1c levels in patients with type 1 diabetes mellitus

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