Clinical features at the onset of childhood type 1 diabetes mellitus in Shenyang, China

Xiao, Ying; Chen, Xiao Juan; Tong, Ya Jie; Zhang, Li Hua

doi:10.1111/j.1440-1754.2009.01657.x

Cited by 31 publications

(26 citation statements)

References 15 publications

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“…The age-related incidence in our series was 54.4% in school-aged children (6-13 years), followed by 23.2% in infants (< 2 years), and 22.2% in toddlers (2-6 years), revealing a higher incidence of T1DM in the older age group and rise of the incidence among younger groups, accounting for 45.5% of patients below 6 years of age. This is in agreement with the findings of Al-Magamsi and Habib [8], Mayer-Davis et al [9], and Xin et al [10], who reported a higher incidence in the age group 5-9 years and 10-14 years and a Frequency of misdiagnosis and mismanagement among the studied group (97 children).…”

Section: Discussionsupporting

confidence: 93%

Etiology, risk factors, clinical features, and pitfalls in the management of newly diagnosed diabetic children and adolescents

Hassan

Hafez

Koura³

et al. 2015

Medical Research Journal

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Objective The aim of this study was to identify the etiology, risk factors, and the most common clinical features of newly diagnosed diabetes in children and adolescents, in addition to the factors related to delayed diagnosis or mismanagement in these children.Materials and methods Ninety-nine children and adolescents aged from one month to 13 years with newly diagnosed type 1 diabetes (T1DM) were recruited from the inpatient department of the Diabetic, Endocrine, and Metabolic Pediatric Unit (DEMPU), New Children Hospital, Cairo University.Results Classic symptoms (polyuria and polydipsia, and weight loss) were the most common symptoms (the first two symptoms in 95.9 and the last one in 90.7%) preceding the diagnosis, and diabetic ketoacidosis was present in 51.5% of cases. Delayed and missed diagnosis was recorded in 49.5% of patients, with no significant relation with age, district of accommodation, or family history of diabetes. Cow's milk feeding was more frequent, being recorded in 75.2% vs. 19.6% with exclusive breast feeding, and positive family history of diabetes was recorded in 77.3%. Severity at presentation showed no significant relation with age, type of feeding, family history of diabetes, or C-peptide level.Conclusion Increased public awareness of early symptoms of diabetes is needed to reduce the frequency and severity of ketoacidosis. In addition, greater medical alertness to the possibility of T1DM in a young child should be stressed. Breastfeeding and avoidance of early cow milk introduction should be encouraged to decrease the risk for T1DM during infancy with its early complications and morbidity.

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Section: Discussionsupporting

confidence: 93%

Etiology, risk factors, clinical features, and pitfalls in the management of newly diagnosed diabetic children and adolescents

Hassan

Hafez

Koura³

et al. 2015

Medical Research Journal

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“…Similar results were observed in the study by Bober et al where they declared that a history of infection or febrile illness could increase the risk of DKA more than six-times (24). Such results were repeated by Xin et al and they found a febrile illness history that elevated DKA risk about two folds (25). Fever in children with DM1 might be a consequence of an infection which could cause insulin resistance by itself through cytokine release and deteriorate the metabolic condition and lead to DKA.…”

Section: Discussionsupporting

confidence: 77%

Factors Associated with Newly Diagnosed Children with Diabetic Ketoacidosis

Mirsadraee¹,

Khajedaluee²,

Vakili³

et al. 2016

J Pediatr Rev

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Background: Diabetes mellitus type 1 is one of the most prevalent endocrine diseases in pediatrics. Diabetic ketoacidosis is considered as one of the most threatening clinical pictures of DM1, especially if occurred as the first presentation of DM1 in children. Objectives: The current study aimed to identify factors which may play a role in DKA onset in children. Methods: This case-control study included all patients under 18 years old who referred to department of pediatrics endocrinology at Mashhad University Hospital (Imam Reza) from January 2013 to December 2015 as newly diagnosed patients with DM1. Patients who fulfilled DKA criteria at diagnosis were considered as DKA group and those who referred with other presentations were considered as control group (non-DKA group). Data were analyzed by SPSS software ver. 16. Results: During the study period, 97 (39.2% male) newly diagnosed patients were included as DKA group. Accordingly 97 genderand age-matched patients were added as non-DKA group. The most prevalent symptoms in both groups were polyuria (91.88%) and polydipsia (88.66%). Fever and cold symptoms were significantly higher in the DKA group (P < 0.001 and P =0.005, respectively). Hemoglobin A1c level was significantly higher in the DKA group (P = 0.001), while body mass index was significantly lower in the DKA group (P = 0.045). Fever and father's education level were the most important risk and protective factors in the DKA onset in newly diagnosed patients with DM1 (adjusted OR = 10.1, 95% CI = 2.9-35.3; P < 0.001 and adjusted OR = 0.5, 95% CI = 0.3 -0.9 and P = 0.019, respectively). Conclusions:In conclusion, a recent febrile illness was found as the strongest risk factor and father's education level as the main protective factor in the DKA to diagnose children with DM1. The study findings suggested that DKA is a severe form of DM1 instead of a neglected or misdiagnosed disease.

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“…with newly diagnosed T1DM. 15 We noted difference in gender distribution between younger and older age groups. There was female predominance in older (10 -15 yrs.)…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile of Type 1 Diabetes Mellitus in Saudi Children: a Hospital Based Study

Rafique¹,

Ishaq²,

Masood³

et al. 2016

Annals KEMU

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Objective: To determine the clinical characteristics of newly diagnosed type 1 diabetes mellitus (T1DM) in children under15 years of age. Cross sectional study conducted at Aseer Central Hospital Abha, Southwestern Saudi Arabia from June 2011 -May 2015. Patients and Methods: Study included 141 Saudi children, < 15 years old with newly diagnosed T1DM. The demographic and laboratory data were collected from file records. The patients were divided into younger (< 5 yr), middle (5 -10 yr) and older (>10 -15 yr)

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Clinical features at the onset of childhood type 1 diabetes mellitus in Shenyang, China

Cited by 31 publications

References 15 publications

Etiology, risk factors, clinical features, and pitfalls in the management of newly diagnosed diabetic children and adolescents

Etiology, risk factors, clinical features, and pitfalls in the management of newly diagnosed diabetic children and adolescents

Factors Associated with Newly Diagnosed Children with Diabetic Ketoacidosis

Clinical Profile of Type 1 Diabetes Mellitus in Saudi Children: a Hospital Based Study

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