Clinical features and prognosis with Guillain-Barré syndrome

Abstract

Background:Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy commonly characterized by rapidly progressive, symmetric weakness and areflexia.Materials and Methods:We retrospectively assessed the clinical manifestations, results of electrodiagnostic tests, functional status and prognosis of 36 children diagnosed with GBS.Results:Based on clinical and electrophysiological findings, the patients were classified as having acute inflammatory demyelinating polyradiculoneuropathy (AIDP) (n = 25), acute motor axonal neuropathy (AMAN) (n = 10) and acute motor-sensory axonal neuropathy (AMSAN) (n = 1). Twenty (55.5%) patients were males and 16 (44.5%) patients were females. The mean age of the 36 patients was 68.1 ± 45.01 months (range, 6–180 months). Five (13.8%) patients were younger than 2 years. The most common initial symptoms were limb weakness, which was documented in 34 (94.4%) patients. In our study, 18 patients (51.4%) showed albuminocytological dissociation (raised protein concentration without pleocytosis) on cerebrospinal fluid (CSF) examination. Three patients (8.3%) required mechanical ventilation therapy during hospitalization. Unfortunately, three (8.3%) patients died; one patient had AIDP and two patients had axonal involvement (one case was AMAN and another case was AMSAN). When we compared the cases of residual sequel/dead and cases of complete recovery for neural involvement type including AIDP, AMAN and AMSAN, we did not find a statistically significant difference between the groups (P > 0.05).Conclusion:Our findings showed that cases of GBS was not uncommon in children younger than 2 years of age, and CSF protein level might be found high in the first week of the disease in about one half of the patients, with a higher rate of morbidity and mortality in patients with axonal involvement than in those with AIDP.

Guillain-Barré Syndrome: A Clinical Study of Twenty Children

“…Korinthenberg et al, [1] dhadke SV et al, [2] akbayram S et al, [9] our study [8]. In our study five children reached severe neurological disability and required ventilatory assistance.…”

A Clinical Study of Multiple Cranial Neuropathies (Mcn)

“…(8) GBS and MFS were the next most common causes of polycranial neuropathy (32 cases, 16%) with mean age of presentation was 23.6 years with youngest age of presentation at 15 months. (9) Acute Motor Axonal Neuropathy was the most common presentation in our case series. Seventh, ninth, and tenth cranial nerves were the affected in all these GB syndrome patients.…”

Retrospective Analysis of Cases with Guillain-Barré Syndrome in Pediatric Intensive Care Unit

“…'nın 15 Türkiye'de yaptığı ve 36 GBS tanılı çocuk hastanın alındığı çalışmada; AEDP sıklığı %69, AMAN sıklığı ise %27 olarak bildirilmektedir. Çalışmamızda da AIDP en sık gözlenen (%45,5) alt tip olarak tespit edilirken, AMAN alt tipi %40,9 gibi yüksek sayılabilecek bir oranla tespit edilmiştir.…”