Guillain-Barré Syndrome: A Clinical Study of Twenty Children

Kumar, Maneesh; Aroor, Shrikiran; Mundkur, Suneel C; Kumar, Sandeep

doi:10.7860/jcdr/2015/8344.5491

Cited by 19 publications

(30 citation statements)

References 6 publications

(6 reference statements)

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“…Sex ratio showed a slight male preponderance in most of the studies. [10][11][12][13] In the present study also, this trend was observed with males constituting 21 (58.3%) of the GBS cases. Rainy (June -September) predominance 14 (38.8%) was noted in our study followed by winter (December-February) 11 (30.5%), even 46 years in demyelinating and 35 years in axonal variant of GBS.…”

Section: Discussionsupporting

confidence: 61%

“…This is comparable to previous studies. 10,11,13,20 Early arrival (<1 week) to hospital, initiation of intravenous Immunoglobulin and intensive care helped to achieve complete recovery in our study. Axonal form of GBS recovered more slowly than those with demyelinating form but outcome at 12 months appear to be equally favorable in two groups.…”

Section: Discussionmentioning

confidence: 88%

“…The study was an attempt to identify the clinical and epidemiological profile of GBS in adults and to compare with previous clinical studies. [10][11][12][13][14][15] (Table 5). Most of the studies were conducted either in children or both adults and children.…”

Section: Discussionmentioning

confidence: 99%

“…Similar finding were reported by Bhargava et al 10 Mean CSF protein was 80.27mg/dl and is comparable to studies by Chio et al 21 and Corston et al 22 Mortality in GBS is associated with respiratory failure requiring mechanical ventilation that prolongs hospital stay. To detect early respiratory failure, all cases with Hughes grade 4 and those with MRC sum score suggestive of moderate (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and severe (0-10) motor deficit were assessed intensively for early respiratory failure. Battery of tests included were baseline measurement of peripheral saturation (Sao2), single breath count (SBC), peak expiratory flow meter and dysphagia tests.…”

Section: Discussionmentioning

confidence: 99%

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Guillain-Barré syndrome: Clinical profile and Consensus to revise Hughes grade 5

Manorenj¹,

Inturi²,

Bhargava³

et al. 2016

IJMEDPH

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Background: Guillain-Barré Syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy and an important cause of acute flaccid paralysis (AFP) worldwide. Respiratory insufficiency requiring ventilator occurs in 30% of patients that prolong the hospital stay, leading to morbidity and mortality. There had been relatively few studies of Guillain-Barre syndrome in adults from South India. Aim: To evaluate clinical profile, epidemiological, laboratory, and electro diagnostic features of patients with GBS in adults. Settings and design: A prospective study was conducted over a period of 4 years at ESIC Superspeciality Hospital, Hyderabad. Materials and methods: Total 36 patients were identified and data was collected. We studied the epidemiological, clinical, electrophysiological features and their outcome. We subdivided Hughes grade 5 into 5A and 5B based on the requirement of ventilator. Statistical Analysis: Data obtained in the study were subjected to statistical analysis with Statistical Package for Social Sciences (SPSS) version 18. Bivariate analysis was done using chi-square test. Results: Of 36 GBS patients, 21(58.3%) were males; the mean age was 35 years. Antecedent infection was found in 23(63.8%). Majority 12 (33%) were in Hughes grade 4, 10 (27.7%) were in Hughes grade 5A. 97.2% had limb weakness. A significant association was found between low Medical research sum score (MRC) and respiratory failure. Most predominant neurophysiological variant was acute inflammatory demyelinating polyradiculoneuropathy (AIDP) 12 (33.3%). Duration of illness was less than 1week in 19 (52.7%) of cases. Asymmetry was observed in 5 (13.8%) and recurrence of Guillain-Barre Syndrome seen in 2 (5.5%) cases. Complete recovery was noted at 6 months in 34 (94.4%) cases. Conclusion: Early diagnosis of respiratory failure and prompt intervention improves patient outcome. Further large sample studies are required to assess respiratory failure and subdivision of Hughes grade 5.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Guillain-Barré syndrome: Clinical profile and Consensus to revise Hughes grade 5

Manorenj¹,

Inturi²,

Bhargava³

et al. 2016

IJMEDPH

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show abstract

“…Inclui-se entre estas a necessidade menos frequente de intubação orotraqueal e de ventilação mecânica (KOUL e ALFUTAISI, 2008;LEE et al, 2008). (TANG et al, 2011;KARIMZADEH et al, 2012;LIN et al, 2012;DEVOS et al, 2013;KUMAR et al, 2015…”

Section: Introductionunclassified