Clinical Features and Outcomes of Takayasu Arteritis with Neurological Symptoms in China: A Retrospective Study

Abstract

Neurological features in patients with TA were variable, and correlated with the number of arteries and the site of artery involvement. Resistant hypertension was one of the most important risk factors for hemorrhagic stroke in patients with TA.

Cerebrovascular events in Takayasu arteritis: a multicenter case-controlled study

“…In a Chinese study, neurological features in patients with TA were variable and correlated with the number of arteries and the site of involvement. Resistant hypertension was one of the most important risk factors for hemorrhagic stroke in patients with TA [48]. We also observed more hypertension in the "stroke" group, although the difference was not statistically significant.…”

Stenting for middle aortic syndrome caused by Takayasu arteritis‐immediate and long‐term outcomes

“…A restenosis rate of 4.5% in another group of patients was observed (Sharma et al, unpublished data). In the present study, only 5 patients (5/46, 10.9%) developed ISR after a follow‐up of 3.1 ± 1.8 years, which was low when compared with similar studies on aorta and other peripheral arteries involving TA , especially considering the long follow‐up duration. Moreover, repeat endovascular therapy for patients with ISR was minimally invasive and effective, which had more advantages than surgical methods.…”

Neurological Involvement in Primary Systemic Vasculitis

“…TA mainly affects large-caliber arteries such as the aorta and its major branches in patients younger than 40 years old (more than 90% of patients are younger than 40), with a female predominance (female to male ratio is 10:1), and is more common in Asians (1). Studies have shown that more than half of patients with TA show neurological manifestations (15, 16) that range from dizziness/headaches to ischemic or hemorrhagic stroke.…”

“…Dizziness and headache are the most common complaints in patients with TA with neurological complications, accounting for ~78.1% (214/274) and 25.5% (70/274), respectively (16). However, headache and dizziness do not necessarily indicate CNS involvement.…”

“…Transient ischemic attack accounts for 3–22.2% of the nervous system manifestations caused by TA. Stroke, as the most severe complication of TA, was found to occur in 10–20% of cases (16–18). Due to lack of knowledgement, the median and average delay between symptom onset and the diagnosis of TA are 2 years (19) and 52.4 months (16), respectively, which delays the treatment of vasculitis.…”