Cerebrovascular events in Takayasu arteritis: a multicenter case-controlled study

Abstract

Stroke is a major cause of disability in TA patients. Internal carotid surgery may be performed with caution because of the risk of stroke after the procedure.

Diagnostic Approach for Stroke Etiology in Takayasu Arteritis

“…Stroke is not rare (15.8%) and is a significant disability factor in the TA patient population [1]. Mechanisms of stroke in TA include large vessel occlusion/stenosis secondary to arterial thrombosis and vasculitis, carotid aneurysm/dissection, embolism from aortic regurgitation, hemodynamic origin due to vascular steal, vasospasm in hypertensive encephalopathy, distal carotid stump embolism, and moyamoya syndrome [1]. The diagnostic workup revealed the large vessel occlusion/stenosis secondary to arterial thrombosis and vasculitis as the stroke etiology of our patient.…”

“…Takayasu arteritis (TA) is a rare large vessel inflammatory arteritis that is usually affecting young women and causes ischemic changes in the vessel wall. It presents with complications of vessel lumen narrowing, such as ischemic pain, claudication, painful carotid, differences in systolic blood pressure (SBP) between arms, decreased brachial artery pulse, bruit over involved arteries, and stroke [1]. Signs and symptoms are not specific or sensitive for its diagnosis.…”

Predictors of cardiovascular complications in patients with Takayasu’s arteritis: results of a retrospective study and analysis of autopsy materials

“…С одной стороны, курение может способствовать быстрому прогрессированию АТ и возникновению необходимости в хирургическом вмешательстве. С другой стороны, оперативные вмешательства на сонных артериях при АТ являются независимым фактором риска инсульта в раннем периоде после вмешательства [14]. Оперативные вмешательства предшествовали развитию MACE у 27 пациентов: в ранний послеоперационный (от 1 до 3-4 сут.)…”

“…Поражение сердца при аутопсии было отмечено в 17 (77%) случаях. Масса сердца составила 325 (270-460) г, длина -10 (4-12) см, ширина -9 (8-10) см, толщина задней стенки левого желудочка (ЛЖ) -6 (1,5-9) мм, толщина стенки ЛЖ -15 (11)(12)(13)(14)(15)(16)(17)(18) мм, в одном случае толщина стенки ЛЖ достигала 22 мм. Ме толщины стенки правого желудочка составила 3 (1-4) мм.…”

Takayasu Arteritis: A Diagnosis Made Using a Multidisciplinary Approach

“…Percutaneous transluminal angioplasty with stenting should be reserved for short lesions that are refractory to medication, but the odds of restenosis occurring are high if inflammation continues after vascular intervention. The use of steroids and tocilizumab preoperatively, and the use of tocilizumab postoperatively are a marvelous combination that not only control inflammation but also reduce the incidence of postoperative complications like stroke [ 3 ] restenosis, aneurysm, thrombosis, embolism, hypertension, neurologic impairment, and death [ 4 ]. Tocilizumab is an antibody, a biological agent that binds interleukin 6 receptor and hinders its pro-inflammatory effect [ 5 ].…”