Clinical features and outcomes of primary hepatic neuroendocrine carcinomas

Park, Chan Hyuk; Chung, Joo Won; Jang, Seon Jung; Chung, Moon Jae; Bang, Seungmin; Park, Seung Woo; Song, Si Young; Chung, Jae Bock; Park, Jeong Youp

doi:10.1111/j.1440-1746.2012.07117.x

Cited by 73 publications

(91 citation statements)

References 31 publications

(91 reference statements)

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“…TACE is an effective method for cytoreduction due to the high sensitivity of neuroendocrine tumors to ischemia [19]. Chemotherapy has also been proposed for treatment of PHNETs with multiple masses or distant metastases; however, its benefit remains questionable [18]. Given the size and location of the lesion in our case, hepatectomy was a feasible option for curative treatment.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Imaging of Primary Hepatic Neuroendocrine Tumors: A Case and Discussion of the Literature

Kellock

Tuong

Harris

et al. 2014

Case Reports in Radiology

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Neuroendocrine tumors (NETs) are derived from neuroendocrine cells that are capable of producing functional peptide hormones. These tumors occur most frequently in the GI tract and lungs. GI NETs frequently metastasize into the liver, though NETs of primary hepatic origin are extremely rare. Ultrasound, CT, and MRI are typically all employed for characterization of these lesions but their appearance on diagnostic imaging can be highly variable. Reported here is an interesting case of a primary hepatic neuroendocrine tumor (PHNET), along with a discussion of the imaging characteristics of these tumors. Additionally, the current standards for definitive diagnosis and treatment of PHNETs are discussed.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Imaging of Primary Hepatic Neuroendocrine Tumors: A Case and Discussion of the Literature

Kellock

Tuong

Harris

et al. 2014

Case Reports in Radiology

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“…The clinical hepatic neuroendocrine tumors mostly was induced by the transfer of intestines and pancreas and others (Pilichowska et al, 1999;Solcia et al, 2000;Modlin et al, 2008;Schwartz et al, 2008;Yao et al, 2008;Zeng et al, 2013) with the histopathologic performance of organ-like growth pattern, the tumor cells was argyrophilic, so they had specific positive performance in the detection of chromogranin A (CgA) and synaptophysin (Syn) of immunohistochemistry (Chang et al, 2007;Huang et al, 2010;Kim et al, 2011;Park et al, 2012). Primarily hepatic neuroendocrine carcinoma (PHNEC) was very rare, accounting for 1-5% of primary liver tumors, and 0.8%-4.0% of systemic neuroendocrine tumors (Pilichowska et al, 1999;Solcia et al, 2000;Yao et al, 2008;Huang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Computer Tomography and Magnetic Resonance Image Manifestations of Primary Hepatic Neuroendocrine Cell Carcinomas

Huang¹,

Yu²,

Sun³

2014

Asian Pacific Journal of Cancer Prevention

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Aim: This study aims to investigate the manifestation of CT, MRI and dynamic enhanced scans for primary hepatic neuroendocrine cell carcinoma. Methods: CT or MRI arterial and venous phase scan images of 19 cases of pathologically confirmed PHNEC were retrospectively analyzed. Results: 14 cases (73.68%) with single lesion, 5 cases (26.3%) with multiple lesions, with an average diameter of 13.2 cm. Some 12 cases (63.16%) showed inhomogeneous enhancement, seven cases (36.8%) showed homogeneous enhancement, 13 cases (68.4%) demonstrated significant enhancement in the arterial phase, 13 cases (68.4%) had significantly enhanced portal venous phase including 7 cases (36.8 %) with portal venous phase density or signal above the arterial phase and 5 cases (26.3%) with the portal vein density or signal below the arterial phase. Seven cases (36.8%) had continued strengthened separate shadows in the center of the lesion. Thrombosis were not seen in portal veins. Conclusion: CT and MRI images of liver cell neuroendocrine carcinoma have certain characteristics that can provide valuable information for diagnosis and differential diagnosis.

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“…On the other hand, PET/CT is an imaging modality reserved for the diagnosis of non functional tumors. Surgical resection is the treatment of choice and transcatheter arterial chemoembolization is an excellent palliative option in cases of recurrent lesions (11) .…”

Section: Primary Hepatic Neuroendocrine Tumormentioning

confidence: 99%

“…Organs involvement is inconstant and secondary, and liver and lungs represent the main common sites for metastatic disease, besides the peritoneum (11) .…”

Section: Desmoplastic Small Round Cell Tumormentioning

confidence: 99%

Tumores hepáticos incomuns: ensaio iconográfico – Parte 2

et al. 2014

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In cases where typical aspects are shown, the diagnosis of most frequent hepatic lesions can be made with some safety by means of several imaging methods; on the other hand, uncommon lesions generally represent a diagnostic challenge for the radiologist. In the present second part of the study, the authors describe four rare hepatic lesions, as follows: primary hepatic lymphoma, myofibroblastic tumor, primary hepatic neuroendocrine tumor and desmoplastic small round cell tumor, approaching their main characteristics and imaging findings with emphasis on computed tomography and magnetic resonance imaging.

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Clinical features and outcomes of primary hepatic neuroendocrine carcinomas

Cited by 73 publications

References 31 publications

Diagnostic Imaging of Primary Hepatic Neuroendocrine Tumors: A Case and Discussion of the Literature

Diagnostic Imaging of Primary Hepatic Neuroendocrine Tumors: A Case and Discussion of the Literature

Computer Tomography and Magnetic Resonance Image Manifestations of Primary Hepatic Neuroendocrine Cell Carcinomas

Tumores hepáticos incomuns: ensaio iconográfico – Parte 2

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