Clinical features and outcomes of primary bone and soft tissue sarcomas in adolescents and young adults

Hashimoto, Kazuhiko; Nishimura, Shunji; Oka, Naohiro; Akagi, Masao

doi:10.3892/mco.2020.1994

Cited by 13 publications

(17 citation statements)

References 32 publications

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“…A Canadian registry showed that the mean operation time for sarcoma was 4 hours, and an operation time > 5 hours increased the likelihood of reoperation because of wound complications, such as infection [23]. In elderly sarcoma patients, the mean operation time is 114.7 minutes and the mean blood loss is 160.7 mL [11]. Additionally, a previous study showed that the infection rate after surgical treatment for sarcomas was 23.3% [24].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the prognosis in AYA sarcoma patients has not improved because AYA sarcoma cases are rare and we lack clinical data [10]. Recently, we described the clinical features and outcomes of AYA sarcomas in our hospital [11]. In the current study, we analyzed the data of sarcomas in AYA patients treated surgically and identified the patients that had poor prognosis to determine optimal surgical treatment approaches.…”

Section: Introductionmentioning

confidence: 98%

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Surgical management of sarcoma in adolescent and young adult patients

Hashimoto¹,

Nishimura

Oka

et al. 2020

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Objective To examine the clinical features and outcomes of adolescent and young adult sarcoma patients who underwent surgical management and clarify important factors associated with prognosis. We reviewed 18 young adult sarcoma patients sarcoma patients treated surgically in our hospital. The tumor site, histology, grade, stage, and American Society of Anesthesiologists-Physical Status before surgery, operation time, intraoperative blood loss, surgical margin, local recurrence, metastasis, and final outcome were investigated. The 3-year survival rate was also calculated. We compared survival based on age, grade, operation time, and intraoperative blood loss and surveyed features of cases of poor outcomes.Results The 3-year survival rate was 61.3%. There was no significant difference in survival based on age, grade, operation time, or intraoperative blood loss. Three of five patients who died of the disease had stage ≥ IV at diagnosis. All patients with inadequate surgical margins developed recurrence and all those with an American Society of Anesthesiologists-Physical Status ≥ 2 died. Patients with a late-stage sarcomas, inadequate tumor margin, or high American Society of Anesthesiologists-Physical Status score had poor prognosis. To achieve a favorable outcome in adolescent and young adult sarcoma patients, early detection and obtaining an adequate surgical margin are important.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Surgical management of sarcoma in adolescent and young adult patients

Hashimoto¹,

Nishimura

Oka

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…A Canadian registry showed that the mean operation time for sarcoma was 4 hours, and an operation time > 5 hours increased the likelihood of reoperation because of wound complications, such as infection [22]. In elderly sarcoma patients, the mean operation time is 114.7 minutes and the mean blood loss is 160.7 mL [11]. Additionally, a previous study showed that the infection rate after surgical treatment for sarcomas was 23.3% [23].…”

Section: Discussionmentioning

confidence: 99%

Surgical management of sarcoma in adolescent and young adult patients

Hashimoto¹,

Nishimura

Oka

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Objective: To examine the clinical features and outcomes of adolescent and young adult sarcoma patients who underwent surgical management and clarify important factors associated with prognosis. We reviewed 18 young adult sarcoma patients sarcoma patients treated surgically in our hospital. The tumor site, histology, grade, stage, and American Society of Anesthesiologists-Physical Status before surgery, operation time, intraoperative blood loss, complications, surgical margin, local recurrence, metastasis, and outcomes were investigated. The 3-year survival rate was also calculated. We compared survival based on age, grade, and surveyed features of poor outcome cases.Results: The 3-year survival rate was 61.3%. There was no significant difference in survival based on age, grade, operation time, or intraoperative blood loss. Three of five patients who died of the disease had stage ≥ IV at diagnosis. All patients with R1 surgical margins developed recurrence and all those with an American Society of Anesthesiologists-Physical Status ≥ 2 died. Patients with late-stage sarcomas, R1 tumor margin, or high American Society of Anesthesiologists-Physical Status score had poor prognoses. To achieve a favorable outcome in adolescent and young adult sarcoma patients, early detection and obtaining R0≥ surgical margin are essential.

show abstract

“…Additionally, prognosis in AYA sarcoma patients has not improved because AYA sarcoma cases are rare, and there are not enough clinical data [10]. Recently, we described the clinical features and outcomes of AYA sarcomas in our hospital [11]. In the current study, we analyzed the data of sarcomas in AYA patients treated surgically and identified the patients that had poor prognosis to determine optimal surgical treatment approaches.…”

Section: Introductionmentioning

confidence: 98%

Surgical management of sarcoma in adolescent and young adult patients

et al. 2020

Self Cite

View full text Add to dashboard Cite

Objective: To examine the clinical features and outcomes of adolescent and young adult sarcoma patients who underwent surgical management and clarify important factors associated with prognosis. We reviewed 18 young adult sarcoma patients sarcoma patients treated surgically in our hospital. The tumor site, histology, grade, stage, and American Society of Anesthesiologists-Physical Status before surgery, operation time, intraoperative blood loss, complications, surgical margin, local recurrence, metastasis, and outcomes were investigated. The 3-year survival rate was also calculated. We compared survival based on age, grade, and surveyed features of poor outcome cases. Results: The 3-year survival rate was 61.3%. There was no significant difference in survival based on age, grade, operation time, or intraoperative blood loss. Three of five patients who died of the disease had stage ≥ IV at diagnosis. All patients with R1 surgical margins developed recurrence and all those with an American Society of Anesthesiologists-Physical Status ≥ 2 died. Patients with late-stage sarcomas, R1 tumor margin, or high American Society of Anesthesiologists-Physical Status score had poor prognoses. To achieve a favorable outcome in adolescent and young adult sarcoma patients, early detection and obtaining R0 ≥ surgical margin are essential.

show abstract

Clinical features and outcomes of primary bone and soft tissue sarcomas in adolescents and young adults

Cited by 13 publications

References 32 publications

Surgical management of sarcoma in adolescent and young adult patients

Surgical management of sarcoma in adolescent and young adult patients

Surgical management of sarcoma in adolescent and young adult patients

Surgical management of sarcoma in adolescent and young adult patients

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