Surgical management of sarcoma in adolescent and young adult patients

Abstract

Objective To examine the clinical features and outcomes of adolescent and young adult sarcoma patients who underwent surgical management and clarify important factors associated with prognosis. We reviewed 18 young adult sarcoma patients sarcoma patients treated surgically in our hospital. The tumor site, histology, grade, stage, and American Society of Anesthesiologists-Physical Status before surgery, operation time, intraoperative blood loss, surgical margin, local recurrence, metastasis, and final outcome were investigated. The 3-year survival rate was also calculated. We compared survival based on age, grade, operation time, and intraoperative blood loss and surveyed features of cases of poor outcomes.Results The 3-year survival rate was 61.3%. There was no significant difference in survival based on age, grade, operation time, or intraoperative blood loss. Three of five patients who died of the disease had stage ≥ IV at diagnosis. All patients with inadequate surgical margins developed recurrence and all those with an American Society of Anesthesiologists-Physical Status ≥ 2 died. Patients with a late-stage sarcomas, inadequate tumor margin, or high American Society of Anesthesiologists-Physical Status score had poor prognosis. To achieve a favorable outcome in adolescent and young adult sarcoma patients, early detection and obtaining an adequate surgical margin are important.