Clinical Features and Natural History of Serous Cystic Neoplasm of the Pancreas

Fukasawa, Mitsuharu; Maguchi, Hiroyuki; Takahashi, Kuniyuki; Katanuma, Akio; Osanai, Manabu; Kurita, Akira; Ichiya, Tamaki; Tsuchiya, Takayoshi; Kin, Toshifumi

doi:10.1159/000320694

Cited by 26 publications

(21 citation statements)

References 32 publications

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“…The main finding of the present study was that the estimated mean growth rate of SCNs is 0.28 cm/year, substantially different from the reports by Tseng et al and Allen et al 9 13 but similar to the observation made by Fukasawa et al 14. According to the line plot shown in figure 1, mean tumour growth seemed to be very slow for the first 7 years after the baseline evaluation and more rapid from the seventh year and onwards.…”

Section: Discussioncontrasting

confidence: 90%

Growth pattern of serous cystic neoplasms of the pancreas: observational study with long-term magnetic resonance surveillance and recommendations for treatment

Malleo

Bassi

Rossini

et al. 2011

Gut

102

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Overall, SCNs grow slowly, and an initial non-operative approach is feasible in all the asymptomatic or minimally symptomatic patients. The oligocystic/macrocystic variant, a history of other non-pancreatic malignancies and patients' age impact on tumour growth. In any case, a significant growth is unlikely to occur before 7 years from the baseline evaluation. Tumour size at the time of diagnosis should not be used for decisional purposes.

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Section: Discussioncontrasting

confidence: 90%

Growth pattern of serous cystic neoplasms of the pancreas: observational study with long-term magnetic resonance surveillance and recommendations for treatment

Malleo

Bassi

Rossini

et al. 2011

Gut

102

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“…Hwang et al confirmed these findings and suggested to consider minimally invasive pancreatectomy in tumors larger than 3 cm regardless of symptoms [65]. However, two more recent studies [12,66] documented a significantly lower mean growth rate of serous cystic neoplasms (0.28-0.29 cm/year) than previously reported. Malleo et al followed a large cohort of patients every year with MRI and observed a very slow rate of tumor growth for the first 7 years (0.1 cm/year), while it substantially accelerated thereafter (0.6 cm/year) [66].…”

Section: Prognosis Treatment and Follow-up Strategiesmentioning

confidence: 84%

“…Serous cystic neoplasms are uncommon tumors that comprise about 16% of all resected cystic tumors of the pancreas, based on large surgical series [7]. Approximately 60-75% of SCAs affect women [8][9][10][11][12], while the mean age of patients who underwent pancreatic surgery for SCAs was 56 years in European series [11], 58 years in Asian series [8] and 62 years in USA series [10].…”

Section: Definition and Epidemiologymentioning

confidence: 99%

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Management of serous cystic neoplasms of the pancreas

Antonini

Fuccio

Fabbri

et al. 2014

Expert Review of Gastroenterology & Hepatology

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Pancreatic serous cystadenomas are uncommon benign tumours that are often found incidentally on routine imaging examinations. Radiological imaging techniques alone have proven to be suboptimal to fully characterize cystic pancreatic lesions. Endoscopic ultrasound, with the addition of fine-needle aspiration in difficult cases, has showed greater diagnostic accuracy than conventional imaging techniques. The best management strategy of these neoplasms is still debated. Surgery should be limited only to symptomatic and highly selected cases and most of the patients should only be strictly monitored. In the current paper, we provide an updated overview on pancreatic serous cystadenomas, focusing our attention on epidemiology, clinical characteristics and diagnostic evaluation; finally, we also discuss different management strategies and areas for future research.

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“…Pancreatic serous cystadenoma is a common type of pancreatic cystic tumor and accounts for 10–15% of all cases of pancreatic cystic tumor and 1-2% of primary pancreatic tumors [1]. These tumors are often small at diagnosis, 31 mm (1–238 mm) on average [2].…”

Section: Introductionmentioning

confidence: 99%

Giant Serous Cystadenoma of the Pancreas (⩾10 cm): The Clinical Features and CT Findings

Liu

Zhou

Zeng

et al. 2016

Gastroenterology Research and Practice

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Purpose. To report the clinical features and CT manifestations of giant pancreatic serous cystadenoma (≥10 cm). Methods. We retrospectively reviewed the clinical features and CT findings of 6 cases of this entity. Results. All 6 patients were symptomatic. The tumors were 10.2 cm–16.5 cm (median value, 13.0 cm). CT imaging revealed that all 6 cases showed microcystic appearances (n = 5) or mixed microcystic and macrocystic appearances (n = 1). Five patients with tumors at the distal end of the pancreas received distal pancreatectomy. Among these 5 patients, 2 patients underwent partial transverse colon resection or omentum resection due to close adhesion. One patient whose tumor was located in the pancreatic head underwent pancreaticoduodenectomy; however, due to encasement of the portal and superior mesenteric veins, the tumor was incompletely resected. One patient had abundant draining veins on the tumor surface and suffered large blood loss (700 mL). After 6–49 months of follow-up the 6 patients showed no tumor recurrence or signs of malignant transformation. Conclusions. Giant pancreatic serous cystadenoma necessitates surgical resection due to large size, symptoms, uncertain diagnosis, and adjacent organ compression. The relationship between the tumors and the neighboring organs needs to be carefully assessed before operation on CT image.

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Clinical Features and Natural History of Serous Cystic Neoplasm of the Pancreas

Cited by 26 publications

References 32 publications

Growth pattern of serous cystic neoplasms of the pancreas: observational study with long-term magnetic resonance surveillance and recommendations for treatment

Growth pattern of serous cystic neoplasms of the pancreas: observational study with long-term magnetic resonance surveillance and recommendations for treatment

Management of serous cystic neoplasms of the pancreas

Giant Serous Cystadenoma of the Pancreas (⩾10 cm): The Clinical Features and CT Findings

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