2021
DOI: 10.1002/pbc.28959
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Clinical features and imaging manifestations of retinoblastoma with hepatic metastasis

Abstract: Clinical data of five patients with hepatic metastases of retinoblastoma were analyzed retrospectively (two had bilateral tumors three had unilateral intraocular tumors). On computed tomography, multiple and single low‐density foci were observed. Four patients had tumor remission, and one showed no response after chemotherapy. Three patients who underwent enucleation were at high risk for extensive choroidal invasion. Central nervous system and bone metastases occurred in all five patients. Neuron‐specific eno… Show more

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Cited by 4 publications
(2 citation statements)
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“…Prognosis remains poor for patients with distant metastasis and high-dose chemotherapy with autologous stem cell rescue has been proven to improve survival in patients with distant metastasis without CNS involvement, like in the case presented here [ 9 , 10 ]. Overall, hepatic metastasis is rare in retinoblastoma and is generally accompanied by skeletal and/or CNS metastases [ 11 , 12 ]. 18F-FDG PET-CT has been shown to play a role in detecting residual/recurrent disease in retinoblastoma patients with locally advanced disease in whom the post-treatment magnetic resonance imaging (MRI) findings were indeterminate [ 13 , 14 ].…”
Section: Discussionmentioning
confidence: 99%
“…Prognosis remains poor for patients with distant metastasis and high-dose chemotherapy with autologous stem cell rescue has been proven to improve survival in patients with distant metastasis without CNS involvement, like in the case presented here [ 9 , 10 ]. Overall, hepatic metastasis is rare in retinoblastoma and is generally accompanied by skeletal and/or CNS metastases [ 11 , 12 ]. 18F-FDG PET-CT has been shown to play a role in detecting residual/recurrent disease in retinoblastoma patients with locally advanced disease in whom the post-treatment magnetic resonance imaging (MRI) findings were indeterminate [ 13 , 14 ].…”
Section: Discussionmentioning
confidence: 99%
“…In children, retinoblastoma (Rb) is a relatively common human genetic malignant ocular tumour (1)(2)(3)(4). It has the characteristics of high incidence, and low survival rate usually occurs in children under 3 years old and can affect one or both two eyes and seriously affect the health of children (5)(6)(7). Rb can be divided into two genetic modes: germline inheritance and non-germline inheritance (8).…”
Section: Introductionmentioning
confidence: 99%