Clinical features and imaging manifestations of retinoblastoma with hepatic metastasis

Abstract

Clinical data of five patients with hepatic metastases of retinoblastoma were analyzed retrospectively (two had bilateral tumors three had unilateral intraocular tumors). On computed tomography, multiple and single low‐density foci were observed. Four patients had tumor remission, and one showed no response after chemotherapy. Three patients who underwent enucleation were at high risk for extensive choroidal invasion. Central nervous system and bone metastases occurred in all five patients. Neuron‐specific enolase and lactate dehydrogenase levels were significantly elevated in all patients. Two patients died (not from hepatic metastasis). Three patients (one with tumor progression and two with shorter courses) are continuing treatment.

An Interesting Case of Post-enucleation Retinoblastoma Presenting With Distant Liver and Skeletal Metastases Detected on 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography

“…Prognosis remains poor for patients with distant metastasis and high-dose chemotherapy with autologous stem cell rescue has been proven to improve survival in patients with distant metastasis without CNS involvement, like in the case presented here [ 9 , 10 ]. Overall, hepatic metastasis is rare in retinoblastoma and is generally accompanied by skeletal and/or CNS metastases [ 11 , 12 ]. 18F-FDG PET-CT has been shown to play a role in detecting residual/recurrent disease in retinoblastoma patients with locally advanced disease in whom the post-treatment magnetic resonance imaging (MRI) findings were indeterminate [ 13 , 14 ].…”

The clinical diagnostic value of plasma miR-592 and miR-217-3p levels in retinoblastoma

“…In children, retinoblastoma (Rb) is a relatively common human genetic malignant ocular tumour (1)(2)(3)(4). It has the characteristics of high incidence, and low survival rate usually occurs in children under 3 years old and can affect one or both two eyes and seriously affect the health of children (5)(6)(7). Rb can be divided into two genetic modes: germline inheritance and non-germline inheritance (8).…”