Clinical Features and Contribution of Virological Findings to the Management of Kaposi Sarcoma in Organ-Allograft Recipients

New Kaposi’s sarcoma-associated herpesvirus variant in men who have sex with men associated with severe pathologies

“…We also found that the C3 variant was the most prevalent KSHV strain in a population of MSM living in France, and that this variant was associated with a less severe clinical presentation of the epidemic form of KS. In patients with epidemic KS, KSHV-DNA viral load tended to be higher for subtype A than for subtype C. These results are consistent with those of previous studies reporting a more aggressive clinical presentation in patients with subtype A than in those with subtype C, for the classic and post-transplantation forms of KS [16,17].…”

Posttransplant Kaposi’s Sarcoma Restricted to the Site of a Previous Deep Venous Thrombosis: Abrupt Onset after Withdrawal of Sirolimus

“…However, it has been suggested that immunosuppressive treatment alone is not enough to explain the appearance of the neoplasm in organ-allograft recipients previously infected with HHV-8 [3]. In this respect, it is worth noting that the abrupt development of KS in our patient was closely related in time with two circumstances: (a) deep venous thrombosis and (b) the withdrawal of sirolimus.…”

Brief Report: De Novo Human Herpesvirus 8 Tumors Induced by Rituximab in Autoimmune or Inflammatory Systemic Diseases

“…The patients with KS (all men) did not have HIV, but they all had at least 1 risk factor for KS: black or dark skin (Fitzpatrick skin phototype >3), homosexuality, or solid organ transplantation . Furthermore, all patients were immunocompromised by previous treatments, including steroids, as indicated by the presence of lymphopenia.…”