Clinical Features, Adenovirus Types, and Local Production of Inflammatory Mediators in Adenovirus Infections

Abstract

Adenovirus infection causes an array of clinical disease and is associated with local production of several proinflammatory cytokines. The observation that nasal wash IL-8 and IL-1alpha concentrations were higher in patients requiring hospitalization suggests that these mediators contribute to disease severity.

Impact of Human Adenovirus Serotype 7 in Hospitalized Children with Severe Fatal Pneumonia in the Philippines

“…The HAdV subspecies B1 includes serotypes 3, 7, and 21, which can cause lower respiratory infections (1,2).…”

Outbreak of Acute Respiratory Infection among Infants in Lisbon, Portugal, Caused by Human Adenovirus Serotype 3 and a New 7/3 Recombinant Strain

“…Human adenoviruses (HAdVs) have been associated with a wide spectrum of clinical diseases with respiratory and gastrointestinal symptoms (23,32). Severe illness can occur in newborns, elderly individuals, and patients with underlying medical conditions.…”

“…Serotype identification is critical for epidemiological surveillance, the detection of new strains, assessment of treatment efficacy, and understanding the pathogenesis of HAdV. For example, acute respiratory disease is primarily caused by HAdV-B1 serotypes 3, 7, 16, and 21; HAdV-B2 serotypes 11 and 14; and HAdV-E serotype 4 (8,23,25,28,35,38,41). Respiratory infections caused by HAdV-B1 serotypes 3 and 7 (16) and HAdV-B2 serotype 14 (17) are potentially fatal.…”

Adenovirus E1B 19-Kilodalton Protein Modulates Innate Immunity through Apoptotic Mimicry

“…Adenovirus induces a proinflammatory response early after infection of the immunocompetent host (23,24). At later times after infection, this response wanes, purportedly because the host immune response clears the viral infection and thus eliminates the proinflammatory stimulus.…”