Clinical feasibility study of combined opto-acoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors

Zalev, Jason; Herzog, Don; Clingman, Bryan; Miller, Tom; Kist, Kenneth; Dornbluth, Nella Carol; McCorvey, B. Michelle; Otto, Pamela M; Ermilov, Sergey A.; Nadvoretsky, Vyacheslav; Conjusteau, André; Su, Richard; Tsyboulski, Dmitri A.; Oraevsky, Alexander A.

doi:10.1117/12.2009112

Cited by 12 publications

(18 citation statements)

References 15 publications

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“…The long-term aim is to achieve quantitative optoacoustic imaging of the optical absorption coefficient in the volume of the tissue and apply laser spectroscopy methods to identify and measure concentrations of molecular constituents associated with specific health condition or disease. The works toward this challenging longterm goal are ongoing [43][44][45][46][47][48][49][50], but it may take another decade to develop commercially viable solutions.…”

Section: History Of Developmentmentioning

confidence: 99%

“…The opportunity to detect and diagnose breast cancer noninvasively differentiating malignant carcinomas from benign adenomas has been the main driving force for developments in the field of OAT since the early pioneering works [23,25,32]. After more than a decade of active development, diagnostic imaging of breast cancer is emerging as the first commercial clinical application for the LOIS [50]. LOIS combines advantages of pronounced optical contrast and sensitive, high-resolution ultrasonic detection resulting in a more advanced imaging system for breast cancer [33,35,64,85].…”

Section: Application Of Lois For Diagnostic Imaging Of Breast Cancermentioning

confidence: 99%

“…All of these technologies, however, are not completely satisfactory for breast radiologists, indicating the need for a safer, more accurate, and easy-to-use technology. A combined ultrasonic plus optoacoustic imaging system Imagio™ based on a handheld probe and operating with video rate is being developed by Seno Medical Instruments to meet the challenges of more accurate diagnostics and demand for an advanced yet simple-to-use modality [50]. Optoacoustic imaging is inherently based on ultrasonic detection, which makes the combination of ultrasound and optoacoustics in one modality both natural and logical.…”

Section: Diagnostic Imaging Of Breast Cancermentioning

confidence: 99%

“…This is the most convenient and frequently used mode of imaging, since typically only one surface of skin or hollow organ is available for measurements. Different designs of optoacoustic imaging systems operating in the backward mode permit tissue illumination either through a hole in the single focused transducer [5,36], through a prism transparent to light but 100% reflecting for acoustic waves [37,71], or through delivering light on the side (around) ultrasonic transducer or array [40,41,50]. The main concern of the backward mode is that significant optical fluence and acoustic energy generated in the skin enter back the array of detectors overwhelming useful optoacoustic signals.…”

Section: Modes Of Optoacoustic Detectionmentioning

confidence: 99%

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Near-Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues

2014

Biomedical Photonics Handbook

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Section: History Of Developmentmentioning

confidence: 99%

Section: Application Of Lois For Diagnostic Imaging Of Breast Cancermentioning

confidence: 99%

Section: Diagnostic Imaging Of Breast Cancermentioning

confidence: 99%

Section: Modes Of Optoacoustic Detectionmentioning

confidence: 99%

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Near-Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues

2014

Biomedical Photonics Handbook

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“…[1][2][3][4][5][6] For breast cancer diagnosis, one promising technique is OA imaging combined with ultrasound (OA/US). [7][8][9][10][11][12][13][14][15][16][17][18][19][20] Combining OA with ultrasound is advantageous because each modality provides information that is complementary to the other. Structural and functional information pertaining to total hemoglobin concentration (c tHb ) and blood oxygen saturation (s O 2 ) can be visualized with OA, while morphological and anatomical information can be obtained with ultrasound.…”

Section: Introductionmentioning

confidence: 99%

Opto-acoustic imaging of relative blood oxygen saturation and total hemoglobin for breast cancer diagnosis

et al. 2019

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Opto-acoustic imaging involves using light to produce sound waves for visualizing blood in biological tissue. By using multiple optical wavelengths, diagnostic images of blood oxygen saturation and total hemoglobin are generated using endogenous optical contrast, without injection of any external contrast agent and without using any ionizing radiation. The technology has been used in recent clinical studies for diagnosis of breast cancer to help distinguish benign from malignant lesions, potentially reducing the need for biopsy through improved diagnostic imaging accuracy. To enable this application, techniques for mapping oxygen saturation differences within tissue are necessary. Using biologically relevant opto-acoustic phantoms, we analyze the ability of an opto-acoustic imaging system to display colorized parametric maps that are generated using a statistical mapping approach. To mimic breast tissue, a material with closely matching properties for optical absorption, optical scattering, acoustic attenuation, and speed of sound is used. The phantoms include two vessels filled with whole blood at oxygen saturation levels determined using a sensor-based approach. A flow system with gas-mixer and membrane oxygenator adjusts the oxygen saturation of each vessel independently. Datasets are collected with an investigational Imagio ® breast imaging system. We examine the ability to distinguish vessels as the oxygen saturation level and imaging depth are varied. At depth of 15 mm and hematocrit of 42%, a sufficient level of contrast to distinguish between two 1.6-mm diameter vessels was measured for an oxygen saturation difference of ∼4.6%. In addition, an oxygenated vessel was visible at a depth of 48 mm using an optical wavelength of 1064 nm, and a deoxygenated vessel was visible to a depth of 42 mm with 757 nm. The results provide insight toward using color mapped opto-acoustic images for diagnosing breast cancer.

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Ultrasound tomography reconstruction algorithm using two opposite rotatable linear arrays for breast cancer diagnosis

et al. 2021

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This article presents a new ultrasound transmission tomography reconstruction algorithm based on a isometric fan-shaped beam along the straight trajectory for an original breast ultrasound imaging system with the cylindrical motion of opposite linear arrays. The ultrasound computed tomography system and measurement scheme are described in detail. The reconstruction algorithm is derived. The numerical breast phantom model is built, including eight structures representing the adipose tissue, glandular tissue, cysts, fibroadenomas, cancer, and calcifications. Using one array as a transmitter and the other one as a receiver, the attenuation distribution in a medium interposed between them is reconstructed. However, limited angle tomography is usually plagued by artifacts along the depth of the image that cause shape distortion to be ellipses, which had an impact on the accurate judgment of the size and shape. B-mode ultrasound images are used as prior information to aid in improving the image quality of limited aperture reconstructions. Simulation results show that the number, location, size, and shape of cancer, cyst, fibroadenoma, and calcification in the numerical breast phantom are reconstructed. Moreover, the quantitative analysis of reconstructed images demonstrates that the reconstruction performance of the region of interest has been greatly improved, which verifies the feasibility of the algorithm using two opposite linear arrays. The reconstruction images are produced by the designed ultrasound tomography reconstruction algorithm, allowing the assessment of the morphology, orientation, internal structure, and margins of lesions in the breast tissue. The ability to create good attenuation images using the cylindrical motion of opposite linear arrays allows reconstructing the three-dimensional image for breast cancer detection and characterization studies.

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Clinical feasibility study of combined opto-acoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors

Cited by 12 publications

References 15 publications

Near-Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues

Near-Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues

Opto-acoustic imaging of relative blood oxygen saturation and total hemoglobin for breast cancer diagnosis

Ultrasound tomography reconstruction algorithm using two opposite rotatable linear arrays for breast cancer diagnosis

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