Near-Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues

doi:10.1201/b17289-24

Cited by 13 publications

(13 citation statements)

References 108 publications

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“…One of Oraevsky's current NIH-sponsored projects involves producing three-dimensional (3-D) images of cancerous tumors in the breast (Figures 1 and 2) in collaboration with the group of Prof. Mark Anastasio at Washington University in St. Louis, and the Department of Diagnostic Radiology at the University of Texas MD Anderson Cancer Center in Houston (directed by Prof. Wei Yang) [1], [2]. To do that, TomoWave engineers designed and produced the Laser Optoacoustic Ultrasonic Imaging System Assembly (LOUISA), capable of providing 3-D full-view optoacoustic tomography, which will be further enabled with the laser-generated ultrasound.…”

Section: Case Study: Breast Cancermentioning

confidence: 99%

Light Plus Sound: Combination technology delivers a one-two punch to disease

Mertz¹

2015

IEEE Pulse

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In just a decade, optoacoustic or photoacoustic imaging has become one of the fastest growing areas of biomedical technology, exploding from just a handful of research groups in the late 1990s to more than 400 dedicated scientists and engineers today. Much of the expansion has come since researchers started pairing optoacoustics with the already-existing technology of medical ultrasound and envisioning how it could easily step into the clinic to fight a diversity of diseases.

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Section: Case Study: Breast Cancermentioning

confidence: 99%

Light Plus Sound: Combination technology delivers a one-two punch to disease

Mertz¹

2015

IEEE Pulse

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“…In OAT, a pulsed laser source irradiates the object. If the optical pulse duration is short compared to the thermal relaxation time of the material, absorption of the optical energy will produce an acoustic pressure field via the photoacoustic effect [33,32,31,50,55,51]. This pressure field will be denoted by the twicedifferentiable function p(r, t), where r ∈ R 3 denotes a 3D spatial coordinate, and t ∈ R + is the temporal coordinate.…”

Section: Canonical Oat Imaging Models In Continuous and Discrete Formsmentioning

confidence: 99%

“…Optoacoustic computed tomography (OAT), also known as photoacoustic computed tomography (PACT), is a rapidly emerging hybrid imaging technique that has received wide-spread attention in the past decade [33,32,45,31,51,50,55]. In OAT, biological tissues are irradiated by short laser pulses and generate internal acoustic wave fields via the photoacoustic effect.…”

Section: Introductionmentioning

confidence: 99%

Impact of nonstationary optical illumination on image reconstruction in optoacoustic tomography

Lou¹,

Wang²,

Oraevsky³

et al. 2016

J. Opt. Soc. Am. A

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Optoacoustic tomography (OAT), also known as photoacoustic tomography, is a rapidly emerging hybrid imaging technique that possesses great potential for a wide range of biomedical imaging applications. In OAT, a laser is employed to illuminate the tissue of interest and acoustic signals are produced via the photoacoustic effect. From these data, an estimate of the distribution of the absorbed optical energy density within the tissue is reconstructed, referred to as the object function. This quantity is defined, in part, by the distribution of light fluence within the tissue that is established by the laser source. When performing three-dimensional imaging of large objects, such as a female human breast, it can be difficult to achieve a relatively uniform coverage of light fluence within the volume of interest when the position of the laser source is fixed. To circumvent this, researchers have proposed illumination schemes in which the relative position of the laser source and ultrasound probe is fixed, and both are rotated together to acquire a tomographic dataset. A problem with this rotating-illumination scheme is that the tomographic data are inconsistent; namely, the acoustic data recorded at each tomographic view angle (i.e., probe position) are produced by a distinct object function. In this work, the impact of this data inconsistency on image reconstruction accuracy is investigated systematically. This is accomplished by use of computer-simulation studies and application of mathematical results from the theory of microlocal analysis. These studies specify the set of image discontinuities that can be stably reconstructed with a nonstationary optical illumination setup. The study also includes a comparison of the ability of iterative and analytic image reconstruction methods to mitigate artifacts attributable to the data inconsistency.

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“…Optoacoustic (OA) imaging is a noninvasive biomedical imaging modality that combines spectral selectivity and high optical contrast based on strong absorption of laser pulses by specific molecules and nanoparticles with the high resolution of ultrasound imaging [1][2][3]. OA imaging is in vivo imaging technology [4,5], where short light energy pulses are absorbed by tissue and converted to thermal energy.…”

Section: Introductionmentioning

confidence: 99%

“…Both forms of hemoglobin, oxygenated and deoxygenated, have much stronger optical absorption coefficients in the NIR (μ a = 1-10 cm −1 ) compared with the NIR optical absorption of other tissues. Therefore, OA imaging represents, possibly, the most powerful modality for imaging blood distribution in organs, the circulation system, and micro blood vessels including angiogenesis-related microvasculature of tumors [2,3,16,17].…”

Section: Introductionmentioning

confidence: 99%