Clinical Factors Associated With Liver Stiffness in Hepatitis B e Antigen–Positive Chronic Hepatitis B Patients

Wong, Grace Lai–Hung; Wong, Vincent Wai‐Sun; Choi, Paul Cheung–Lung; Chan, Anthony Wing–Hung; Chim, Angel Mei‐Ling; Yiu, Karen; Chan, H.L.-Y.; Chan, Francis K.L.; Sung, Joseph J.Y.

doi:10.1016/j.cgh.2008.10.023

Cited by 77 publications

(81 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, liver cirrhosis may occur in patients with intermediate HBV DNA levels, as they have a prolonged but unsuccessful immune clearance of the virus that leads to more liver damage. Hence a bell-shaped rather than a linear relationship was observed between liver fibrosis and HBV DNA levels among HBeAg-positive patients 4. This phenomenon may explain the lack of consistent effect of serum HBV DNA level on the risk of liver cirrhosis in our present study.…”

contrasting

confidence: 51%

Authors' response

Wong

Chan

2010

Gut

View full text Add to dashboard Cite

contrasting

confidence: 51%

Authors' response

Wong

Chan

2010

Gut

View full text Add to dashboard Cite

“…In patients with chronic hepatitis B, high viral load is usually associated with active disease and histological progression in the long run. Patients with high HBV DNA are more likely to have advanced liver fibrosis or cirrhosis [49,50]. Besides, large epidemiological studies confirmed that patients with high viral load are at increased risk of hepatocellular carcinoma [2,51,52].…”

Section: Discussionmentioning

confidence: 97%

Hepatitis B virus infection and fatty liver in the general population

Wong

Chu

et al. 2012

Journal of Hepatology

206

204

View full text Add to dashboard Cite

“…Considering no any biochemical parameters associated with significant fibrosis, therefore age over 30 years might be a risk factor in HBeAg-positive patients with PNALT. One study from Hong Kong approved us by indicating that the risk of liver fibrosis increases after age 35 in HBeAg-positive patients [26]. Nevertheless it concentrated on patients with advanced fibrosis (F3 - F4) by TE measurement instead of histological proof.…”

Section: Discussionmentioning

confidence: 99%

Significant Fibrosis Is Not Rare in Chinese Chronic Hepatitis B Patients with Persistent Normal ALT

Liao

Wang

Lin³

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

BackgroundLimited studies have been done on chronic hepatitis B (CHB) patients defined according to the latest Asian-Pacific Association for the Study of the Liver guideline with liver histology by a large sample size.MethodsWe retrospectively evaluated liver histological characteristics on a cohort of consecutive treatment-naive CHB patients with persistent normal alanine aminotransferase (PNALT) or elevated ALT from May 2005 to October 2011. Histological assessment was based on the Metavir scoring system, significant abnormality was defined as necroinflammation grade ≥A2 and/or fibrosis stage ≥F2.ResultsA total of 675 CHB patients were recruited, including 516 HBeAg-positive and 159 HBeAg-negative patients. In HBeAg-positive patients, significant fibrosis was found 49.4% (42/85) in PNALT, 69.8% (88/126) in ALT 1-2×upper limit normal (ULN) and 81.6% (249/305) in ALT>2×ULN group, respectively. In HBeAg-negative patients, significant fibrosis was found 30.9% (17/55) in PNALT, 73.3% (33/45) in ALT 1-2×ULN and 94.9% (56/59) in ALT>2×ULN group, respectively. HBeAg-positive patients with PNALT over 30 years old had a higher frequency of significant fibrosis than those under 30 years old (87.5% vs. 45.5%, P = 0.058). Multivariate logistic regression analysis indicated increasing age (P = 0.012), higher aspartate aminotransferase (AST) (P < 0.001) and lower HBV DNA (P < 0.001) were associated with significant necroinflammation, while higher AST (P < 0.001), lower albumin (P = 0.027) and HBV DNA (P = 0.004) were associated with significant fibrosis in HBeAg-positive patients with elevated ALT. Higher AST was associated with significant necroinflammation in HBeAg-negative patients with elevated ALT (P = 0.009).ConclusionsSignificant fibrosis is not rare in Chinese CHB patients with PNALT, especially HBeAg-positive patients over 30 years old.

show abstract

Clinical Factors Associated With Liver Stiffness in Hepatitis B e Antigen–Positive Chronic Hepatitis B Patients

Cited by 77 publications

References 31 publications

Authors' response

Authors' response

Hepatitis B virus infection and fatty liver in the general population

Significant Fibrosis Is Not Rare in Chinese Chronic Hepatitis B Patients with Persistent Normal ALT

Contact Info

Product

Resources

About