Clinical factors are associated with vitamin D levels in IBD patients: A retrospective analysis

Schäffler, Holger; Schmidt, Martin; Huth, A; Reiner, John M.; Glass, Änne; Lamprecht, Georg

doi:10.1111/1751-2980.12565

Cited by 34 publications

(42 citation statements)

References 41 publications

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“…The same study demonstrated that IBD patients also had increased odds of lower vitamin D levels compared to matched controls. Due to the potential mechanistic link between vitamin D and colitis and the high prevalence of vitamin D deficiency in IBD patients, many groups have sought to examine the impact of vitamin D levels on IBD clinical outcomes, often with conflicting results. Many of these previous studies were limited by their small sample size and inability to detect differences in clinical outcomes between low and high vitamin D groups.…”

Section: Introductionmentioning

confidence: 99%

Systematic review with meta‐analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease

Gubatan

Chou

Nielsen

et al. 2019

Aliment Pharmacol Ther

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Summary Background Vitamin D deficiency is highly prevalent among patients with IBD, however, data on its association with clinical outcomes are conflicting. Aim To perform a systematic review and meta‐analysis to explore the association of low vitamin D status with clinical outcomes in patients with IBD. Methods We searched PubMed, Embase, Scopus and Web of Science from inception to February 2018 for observational studies evaluating the association of low 25(OH)D status on IBD disease activity, mucosal inflammation, clinical relapse and quality of life. Odds ratios (ORs) were pooled and analysed using a random effects model. Results Twenty‐seven studies were eligible for inclusion comprising 8316 IBD patients (3115 ulcerative colitis, 5201 Crohn's disease). Among IBD patients, low 25(OH)D status was associated with increased odds of disease activity (OR 1.53, 95% CI 1.32‐1.77, I2 = 0%), mucosal inflammation (OR 1.25, 95% CI 1.06‐1.47, I2 = 0%), low quality of life (QOL) scores (OR 1.30, 95% CI 1.06‐1.60, I2 = 0%) and future clinical relapse (OR 1.23, 95% CI 1.03‐1.47, I2 = 0%). In subgroup analysis, low vitamin D status was associated with Crohn's disease activity (OR 1.66, 95% CI 1.36‐2.03, I2 = 0%), mucosal inflammation (OR 1.39, 95% CI 1.03‐1.85, I2 = 0%), clinical relapse (OR 1.35, 95% CI 1.14‐1.59, I2 = 0%), and low QOL scores (OR 1.25, 95% CI 1.04‐1.50, I2 = 0%) and ulcerative colitis disease activity (OR 1.47, 95% CI 1.03‐2.09, I2 = 0%) and clinical relapse (OR 1.20, 95% 1.01‐1.43, I2 = 0%). Conclusions Low 25(OH)D status is a biomarker for disease activity and predictor of poor clinical outcomes in IBD patients.

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Section: Introductionmentioning

confidence: 99%

Systematic review with meta‐analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease

Gubatan

Chou

Nielsen

et al. 2019

Aliment Pharmacol Ther

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“…Mouse models with colitis have been shown to have altered microbiota [45], and vitamin D administration in the same models was shown to alter the gut microbiome and protect against colitis [46]. Similar data exists for CD, where lower vitamin D levels are found in patients with small bowel CD or in those with resected segments of the small bowel [5]. There are some limitations to this study.…”

Section: Discussionmentioning

confidence: 71%

“…An explanation for this might be the fact that the mean SCCAI in the cohort of UC patients studied was overall low and only very few patients had evidence of active disease. There is evidence from various studies that vitamin D levels are lower in patients with active disease [5,9,22,23]. One study demonstrates that patients with UC with low baseline vitamin D levels were also more likely to suffer from disease relapse over months [24].…”

Section: Discussionmentioning

confidence: 99%

“…In CD, patients receiving anti-TNF therapy has been shown to result in improved levels of vitamin D [5]. Different studies demonstrate that patients with lower vitamin D levels at diagnosis usually have a more severe disease course [33,34].…”

Section: Discussionmentioning

confidence: 99%

“…There are studies that demonstrate that patients with UC have vitamin D deficiency similar to patients with CD [2,[4][5][6], though vitamin D levels may be lower in patients with CD than in UC [7]. Contrarily, a meta-analysis by Del Pinto et al [8] reported odds of 2.28 of vitamin D deficiency in UC patients compared to CD patients (1.63).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D and Ulcerative Colitis: Is There a Relationship with Disease Extent?

Zammit

Schembri

Pisani

et al. 2018

Dig Dis

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Introduction: Patients with ulcerative colitis (UC) can suffer from low serum vitamin D that can result in complications such as low bone mineral density. It can also reflect underlying disease severity. Methods: One hundred and ninety-seven patients previously diagnosed with UC from 2 European centers were prospectively recruited through the out-patient clinics. Clinical features (Montreal Classification, age, gender, previous and current medications, surgery), disease activity (Simple Clinical Colitis Activity Index [SCCAI]), blood investigations including serum inflammatory markers, and serum vitamin D were analyzed. The vitamin D levels were compared to a group of age- and gender-matched healthy controls. Results: Mean vitamin D levels were lower in patients with UC (54.6 nmol/L) than in controls (80.7 nmol/L; p = 0.0001). Mean vitamin D levels was lowest in patients with extensive UC (E3; p = 0.0001). Serum vitamin D was not significantly different across treatment groups (p = 0.876). There was no statistical difference in vitamin D levels across patients receiving calcium and vitamin D supplements (p = 0.35) and there was no statistical correlation with SCCAI (p = 0.22). Conclusions: This study confirms the existence of low serum vitamin D in patients with UC when compared to healthy controls. It also provides evidence of an existing relationship between disease extent and serum vitamin D.

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High-dose vitamin D supplementation in multiple sclerosis: a systematic review of clinical effects and future directions

Aderinto,

Olatunji,

Kokori

et al. 2024

Discov Med

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Vitamin D deficiency is common in multiple sclerosis (MS) patients. This review explores the potential benefits and limitations of high-dose vitamin D supplementation in MS management. We reviewed relevant literature on the effects of high-dose vitamin D supplementation on relapse rates, disability progression, quality of life, and MRI markers of disease activity in MS patients. Additionally, we discussed the mechanisms by which vitamin D might influence MS, potential adverse effects, and future research directions. Studies suggest that high-dose vitamin D supplementation may reduce relapse rates and improve MRI markers of disease activity in MS. However, the evidence for its impact on disability progression and quality of life remains inconclusive. Vitamin D’s immunomodulatory properties are well-documented, and its potential for neuroprotection and neurogenesis warrants further investigation. High-dose vitamin D supplementation holds promise as a complementary or disease-modifying therapy for MS. However, further robust research is required to solidify its role in clinical practice. Exploring vitamin D’s multifaceted effects on the immune system, neuroprotection, and neurogenesis paves the way for novel therapeutic strategies to improve the lives of individuals with MS.

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Clinical factors are associated with vitamin D levels in IBD patients: A retrospective analysis

Abstract: Vitamin D deficiency is common in patients with IBD. However, certain clinical situations lead to significantly lower vitamin D levels and may therefore require close monitoring for vitamin D deficiency.

Cited by 34 publications

References 41 publications

Systematic review with meta‐analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease

Systematic review with meta‐analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease

Vitamin D and Ulcerative Colitis: Is There a Relationship with Disease Extent?

High-dose vitamin D supplementation in multiple sclerosis: a systematic review of clinical effects and future directions

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