Clinical Experiences with a New β-Sympathicomimetic Substance in the Provoked Attack in Occupational Asthma

Abstract

18 untreated men with confirmed uncomplicated allergic bronchial asthma induced by flour were examined. In each patient, an attack of asthma was initially provoked by inhalatest tion and treated 40 min later. In a double-blind study, either 0.4 mg Th 1165a, the p-hydroxyphenyl derivative of orciprenaline, or an aerosol containing only propellant was used.The broncho-pulm’onary reaction was investigated by the technique of body plethysmography, the cardiovascular effects on the basis of the pulse rate and blood pressure.The following results were obtained: (1) the airway resistance and the endexpiratory thoracic gas volume were normalised within a maximum of 5 min; (2) the effect was maintained for at least 4 h and thus virtually as long as an acute, untreated uncomplicated allergic asthmatic attack; (3) 30–120 min after the administration of the drug, a maximum effect period was reached accompanied by specific conductance values which were higher than before the attack; (4) the bronchopulmonary therapeutic effect was significant as compared with the control group; (5) the pulse rate and the diastolic blood pressure were not influenced, and (6) the systolic blood pressure was depressed by about 10 mm Hg. The deviations were statistically not significant.All in all, the results indicate a largely selective broncho-spasmolytic effect via the stimulation of β₂-adrenergic receptors.

Diagnosis and Management of Work-Related Asthma

“…Other Medical Regimens Used During SICs: Studies have assessed the effect of medications on asthmatic responses and airway responsiveness induced by various occupational sensitizing agents (mainly diisocyanates and flour) during SICs in subjects with sensitizer-induced OA. [233][234][235][236][237] Although these data bring additional information on pathophysiology, they have a limited impact on the pharmacologic management of patients with sensitizer-induced OA.…”