Bronchodilator Effect of a New Oral Beta Adrenoreceptor Stimulant, Th1165a

Geutnei, Aida M.; Miller, William; Miller, John A.; Gast, L.R.

doi:10.1378/chest.70.4.460

Cited by 26 publications

(4 citation statements)

References 11 publications

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“…Larsson and Svedmyr (6) suggested that a better effect on the small airways was seen with oral treatment by ß-adrenergic agents than inhalations. As we did not compare fenoterol to other ßi-agents, we are unable to say whether or not it is superior, but this has been suggested by adult studies (2,5).…”

Section: Discussionmentioning

confidence: 83%

“…It has a maximal effect on the bronchial muscle and minimal cardiovascular side effects (5). Adult studies have shown fenoterol to be a highly effective bronchodilator with a prolonged duration of action (5,9). The recommended adult dose is known (5,9), however, this is not the case with children (l, 12).…”

mentioning

confidence: 99%

“…Adult studies have shown fenoterol to be a highly effective bronchodilator with a prolonged duration of action (5,9). The recommended adult dose is known (5,9), however, this is not the case with children (l, 12). The purpose of this study was to assess the dose of oral fenoterol which provided optimal bronchodilation with minimal side effects in children.…”

mentioning

confidence: 99%

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Dose-Response Study of Oral Fenoterol in Asthmatic Children

Gurwitz¹,

Levison²

1980

Dev Pharmacol Ther

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To assess the dose of oral fenoterol, a ß2-receptor stimulant, which provided optimal bronchodilation with minimal side effects, we studied 12 children using a doubleblind crossover comparison of three dose levels, 2.5, 5 and 7.5 mg, and a placebo. Ventilatory function, pulse rate, blood pressure and clinical examination were compared over a 3-hour period. Administration offenoterol resulted in bronchodilation; a maximal effect was seen at 60-90 min lasting over the period of the study. 7.5 mg of fenoterol produced the maximal bronchodilation, but it was not significantly different from 5 mg. Side effects were minimal and no significant drug-response relationship was noted for blood pressure and pulse rate. 5 mg of fenoterol provided optimal bronchodilation with minimal side effects.

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Section: Discussionmentioning

confidence: 83%

mentioning

confidence: 99%

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Dose-Response Study of Oral Fenoterol in Asthmatic Children

Gurwitz¹,

Levison²

1980

Dev Pharmacol Ther

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“…We now show that feno terol also inhibits histamine release from human chopped lung challenged with antigen. Furthermore, our data demonstrate that fenoterol is an inhibitor of antigen-induced histamine release in the basophil sys tem, another in vitro model relevant to human ana phylaxis [8], Fenoterol is a potent bronchodilator [28] useful in the treatment of allergic reactions in man [5,26]. Our results indicate that fenoterol is a potent inhi bitor of the IgE-mediated release of chemical media tors from human basophils and mast cells and that the effect is mediated by increasing the cAMP level in these cells.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of IgE-Mediated Histamine Release from Human Basophils and Mast Cells by Fenoterol

Marone

Ambrosio

Bonaduce

et al. 1984

Int Arch Allergy Immunol

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Fenoterol, a β₂-adrenergic agonist recently introduced to treat asthmatic disorders, inhibits antigen-induced histamine release from human basophil leukocytes and lung mast cells in a dose-dependent fashion. The dose-response inhibition curve is paralleled by a fenoterol-induced increase in the cAMP levels of human leukocyte preparations. The relationship between the effect of fenoterol and cAMP level is supported by the finding that the β₂-adrenergic agonist only inhibits the first stage of antigen-induced histamine release and not the release caused by the Ca²⁺ ionophore, A23187. Propranolol, a competitive antagonist of β₂-adrenergic receptor, blocks the inhibition of release and the cAMP accumulation caused by fenoterol. Finally, theophylline, a cAMP phosphodiesterase inhibitor, synergistically potentiates the inhibitory effect of fenoterol on histamine release and the accumulation of cAMP. These data suggest that fenoterol may modulate the in vivo release of the mediators of immediate hypersensitivity reactions via the activation of β₂-adrenergic receptor linked to adenylate cyclase on human basophils and mast cells.

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Comparison of Fenoterol, Isoproterenol, and Isoetharine with Phenylephrine Aerosol in Asthma

Spellman

Gruebel

Epstein

et al. 1983

The Journal of Clinical Pharma

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The bronchodilator effect of fenoterol hydrobromide (0.5, 1.25, and 2.5 mg) was compared with either isoproterenol (2.8 mg) or isoetharine (5 mg) with phenylephrine (1.25 mg) in a double-blind placebo-controlled study. When delivered by an intermittent positive-pressure breathing device to 24 nonsmoking young adult asthmatic subjects, fenoterol produced significant improvement in forced expiratory volume at 1 second (FEV1), in maximum midexpiratory flow (FEF25-75%), and in forced expiratory flow at 25 per cent of vital capacity (FEF25%) for 6 to 8 hours, whereas isoproterenol and isoetharine with phenylephrine produced improvement for 1 and 2 hours, respectively. The lowest dosage of fenoterol was as effective as the highest but had fewer adverse effects.

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Bronchodilator Effect of a New Oral Beta Adrenoreceptor Stimulant, Th1165a

Cited by 26 publications

References 11 publications

Dose-Response Study of Oral Fenoterol in Asthmatic Children

Dose-Response Study of Oral Fenoterol in Asthmatic Children

Inhibition of IgE-Mediated Histamine Release from Human Basophils and Mast Cells by Fenoterol

Comparison of Fenoterol, Isoproterenol, and Isoetharine with Phenylephrine Aerosol in Asthma

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